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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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2014-January Volume 31 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Short interspersed CAN SINE elements as prognostic markers in canine mammary neoplasia

  • Authors:
    • Gabriela B. Gelaleti
    • Adriana Granzotto
    • Camila Leonel
    • Bruna V. Jardim
    • Marina G. Moschetta
    • Claudia M.A. Carareto
    • Debora AP.P.C. Zuccari

  • View Affiliations / Copyright

    Affiliations: Program of Post-Graduate in Genetics, UNESP - São Paulo State University, São José do Rio Preto, São Paulo, Brazil, Laboratório de Evolução Molecular de Insetos, UNESP - São Paulo State University, São José do Rio Preto, São Paulo, Brazil, Laboratório de Investigação Molecular do Câncer, FAMERP - Faculty of Medicine of São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil
  • Pages: 435-441
    |
    Published online on: October 31, 2013
       https://doi.org/10.3892/or.2013.2827
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Abstract

The genome of mammals is characterized by a large number of non-LTR retrotransposons, and among them, the CAN SINEs are characteristics of the canine species. Small amounts of DNA freely circulate in normal blood serum and high amounts are found in human patients with cancer, characterizing it as a candidate tumor-biomarker. The aim of this study was to estimate, through its absolute expression, the number of copies of CAN SINE sequences present in free circulating DNA of female dogs with mammary cancer, in order to correlate with the clinical and pathological characteristics and the follow-up period. The copy number of CAN SINE sequences was estimated by qPCR in 28 female dogs with mammary neoplasia. The univariate analysis showed an increased number of copies in female dogs with mammary tumor in female dogs >10 years old (p=0.02) and tumor time >18 months (p<0.05). The Kaplan-Meier test demonstrated a negative correlation between an increased number of copies and survival time (p=0.03). High amounts of CAN SINE fragments can be good markers for the detection of tumor DNA in blood and may characterize it as a marker of poor prognosis, being related to female dogs with shorter survival times. This estimate can be used as a prognostic marker in non-invasive breast cancer research and is useful in predicting tumor progression and patient monitoring.

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Copy and paste a formatted citation
Spandidos Publications style
Gelaleti GB, Granzotto A, Leonel C, Jardim BV, Moschetta MG, Carareto CM and Zuccari DA: Short interspersed CAN SINE elements as prognostic markers in canine mammary neoplasia. Oncol Rep 31: 435-441, 2014.
APA
Gelaleti, G.B., Granzotto, A., Leonel, C., Jardim, B.V., Moschetta, M.G., Carareto, C.M., & Zuccari, D.A. (2014). Short interspersed CAN SINE elements as prognostic markers in canine mammary neoplasia. Oncology Reports, 31, 435-441. https://doi.org/10.3892/or.2013.2827
MLA
Gelaleti, G. B., Granzotto, A., Leonel, C., Jardim, B. V., Moschetta, M. G., Carareto, C. M., Zuccari, D. A."Short interspersed CAN SINE elements as prognostic markers in canine mammary neoplasia". Oncology Reports 31.1 (2014): 435-441.
Chicago
Gelaleti, G. B., Granzotto, A., Leonel, C., Jardim, B. V., Moschetta, M. G., Carareto, C. M., Zuccari, D. A."Short interspersed CAN SINE elements as prognostic markers in canine mammary neoplasia". Oncology Reports 31, no. 1 (2014): 435-441. https://doi.org/10.3892/or.2013.2827
Copy and paste a formatted citation
x
Spandidos Publications style
Gelaleti GB, Granzotto A, Leonel C, Jardim BV, Moschetta MG, Carareto CM and Zuccari DA: Short interspersed CAN SINE elements as prognostic markers in canine mammary neoplasia. Oncol Rep 31: 435-441, 2014.
APA
Gelaleti, G.B., Granzotto, A., Leonel, C., Jardim, B.V., Moschetta, M.G., Carareto, C.M., & Zuccari, D.A. (2014). Short interspersed CAN SINE elements as prognostic markers in canine mammary neoplasia. Oncology Reports, 31, 435-441. https://doi.org/10.3892/or.2013.2827
MLA
Gelaleti, G. B., Granzotto, A., Leonel, C., Jardim, B. V., Moschetta, M. G., Carareto, C. M., Zuccari, D. A."Short interspersed CAN SINE elements as prognostic markers in canine mammary neoplasia". Oncology Reports 31.1 (2014): 435-441.
Chicago
Gelaleti, G. B., Granzotto, A., Leonel, C., Jardim, B. V., Moschetta, M. G., Carareto, C. M., Zuccari, D. A."Short interspersed CAN SINE elements as prognostic markers in canine mammary neoplasia". Oncology Reports 31, no. 1 (2014): 435-441. https://doi.org/10.3892/or.2013.2827
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