Activation of the JAK-STAT3 pathway is associated with the growth of colorectal carcinoma cells

  • Authors:
    • Xubin Wei
    • Gang Wang
    • Wei Li
    • Xupang Hu
    • Qinghong Huang
    • Ke Xu
    • Wenjia Lou
    • Jia Wu
    • Chen Liang
    • Qibin Lou
    • Chen Qian
    • Li Liu
  • View Affiliations

  • Published online on: November 20, 2013     https://doi.org/10.3892/or.2013.2858
  • Pages: 335-341
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Abstract

Excessive activation of inflammatory signaling pathways facilitates colorectal carcinoma (CRC) malignancy. Continuous activation of the Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) pathway plays a central role in the development and progression of CRC. With the intent to explore whether attenuation of the JAK-STAT3 signaling axis inhibits cancer cell proliferation or induces apoptosis, a sophisticated oncolytic adenoviral vector, AdCN305, carrying the SOCS3 gene was used to treat CRC cells. Our data revealed that i) in CRC cells, STAT3 was continuously activated by phosphorylation, and SOCS3 was at a relative low expression level; and ii) AdCN305-cppSOCS3 inhibited the continuous activation of the JAK/STAT3 pathway, suppressed CRC cell growth and induced apoptosis, in vitro and in vivo. We proved that SOCS3, a negative regulator of the JAK-STAT3 pathway, efficiently inhibited the activation of the pathway and decreased levels of downstream factors which regulate cell proliferation and the cell cycle.
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2014-January
Volume 31 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Wei X, Wang G, Li W, Hu X, Huang Q, Xu K, Lou W, Wu J, Liang C, Lou Q, Lou Q, et al: Activation of the JAK-STAT3 pathway is associated with the growth of colorectal carcinoma cells. Oncol Rep 31: 335-341, 2014
APA
Wei, X., Wang, G., Li, W., Hu, X., Huang, Q., Xu, K. ... Liu, L. (2014). Activation of the JAK-STAT3 pathway is associated with the growth of colorectal carcinoma cells. Oncology Reports, 31, 335-341. https://doi.org/10.3892/or.2013.2858
MLA
Wei, X., Wang, G., Li, W., Hu, X., Huang, Q., Xu, K., Lou, W., Wu, J., Liang, C., Lou, Q., Qian, C., Liu, L."Activation of the JAK-STAT3 pathway is associated with the growth of colorectal carcinoma cells". Oncology Reports 31.1 (2014): 335-341.
Chicago
Wei, X., Wang, G., Li, W., Hu, X., Huang, Q., Xu, K., Lou, W., Wu, J., Liang, C., Lou, Q., Qian, C., Liu, L."Activation of the JAK-STAT3 pathway is associated with the growth of colorectal carcinoma cells". Oncology Reports 31, no. 1 (2014): 335-341. https://doi.org/10.3892/or.2013.2858