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2014-January Volume 31 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Activation of the JAK-STAT3 pathway is associated with the growth of colorectal carcinoma cells

  • Authors:
    • Xubin Wei
    • Gang Wang
    • Wei Li
    • Xupang Hu
    • Qinghong Huang
    • Ke Xu
    • Wenjia Lou
    • Jia Wu
    • Chen Liang
    • Qibin Lou
    • Chen Qian
    • Li Liu
  • View Affiliations / Copyright

    Affiliations: School of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, P.R. China
  • Pages: 335-341
    |
    Published online on: November 20, 2013
       https://doi.org/10.3892/or.2013.2858
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Abstract

Excessive activation of inflammatory signaling pathways facilitates colorectal carcinoma (CRC) malignancy. Continuous activation of the Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) pathway plays a central role in the development and progression of CRC. With the intent to explore whether attenuation of the JAK-STAT3 signaling axis inhibits cancer cell proliferation or induces apoptosis, a sophisticated oncolytic adenoviral vector, AdCN305, carrying the SOCS3 gene was used to treat CRC cells. Our data revealed that i) in CRC cells, STAT3 was continuously activated by phosphorylation, and SOCS3 was at a relative low expression level; and ii) AdCN305-cppSOCS3 inhibited the continuous activation of the JAK/STAT3 pathway, suppressed CRC cell growth and induced apoptosis, in vitro and in vivo. We proved that SOCS3, a negative regulator of the JAK-STAT3 pathway, efficiently inhibited the activation of the pathway and decreased levels of downstream factors which regulate cell proliferation and the cell cycle.
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Copy and paste a formatted citation
Spandidos Publications style
Wei X, Wang G, Li W, Hu X, Huang Q, Xu K, Lou W, Wu J, Liang C, Lou Q, Lou Q, et al: Activation of the JAK-STAT3 pathway is associated with the growth of colorectal carcinoma cells. Oncol Rep 31: 335-341, 2014.
APA
Wei, X., Wang, G., Li, W., Hu, X., Huang, Q., Xu, K. ... Liu, L. (2014). Activation of the JAK-STAT3 pathway is associated with the growth of colorectal carcinoma cells. Oncology Reports, 31, 335-341. https://doi.org/10.3892/or.2013.2858
MLA
Wei, X., Wang, G., Li, W., Hu, X., Huang, Q., Xu, K., Lou, W., Wu, J., Liang, C., Lou, Q., Qian, C., Liu, L."Activation of the JAK-STAT3 pathway is associated with the growth of colorectal carcinoma cells". Oncology Reports 31.1 (2014): 335-341.
Chicago
Wei, X., Wang, G., Li, W., Hu, X., Huang, Q., Xu, K., Lou, W., Wu, J., Liang, C., Lou, Q., Qian, C., Liu, L."Activation of the JAK-STAT3 pathway is associated with the growth of colorectal carcinoma cells". Oncology Reports 31, no. 1 (2014): 335-341. https://doi.org/10.3892/or.2013.2858
Copy and paste a formatted citation
x
Spandidos Publications style
Wei X, Wang G, Li W, Hu X, Huang Q, Xu K, Lou W, Wu J, Liang C, Lou Q, Lou Q, et al: Activation of the JAK-STAT3 pathway is associated with the growth of colorectal carcinoma cells. Oncol Rep 31: 335-341, 2014.
APA
Wei, X., Wang, G., Li, W., Hu, X., Huang, Q., Xu, K. ... Liu, L. (2014). Activation of the JAK-STAT3 pathway is associated with the growth of colorectal carcinoma cells. Oncology Reports, 31, 335-341. https://doi.org/10.3892/or.2013.2858
MLA
Wei, X., Wang, G., Li, W., Hu, X., Huang, Q., Xu, K., Lou, W., Wu, J., Liang, C., Lou, Q., Qian, C., Liu, L."Activation of the JAK-STAT3 pathway is associated with the growth of colorectal carcinoma cells". Oncology Reports 31.1 (2014): 335-341.
Chicago
Wei, X., Wang, G., Li, W., Hu, X., Huang, Q., Xu, K., Lou, W., Wu, J., Liang, C., Lou, Q., Qian, C., Liu, L."Activation of the JAK-STAT3 pathway is associated with the growth of colorectal carcinoma cells". Oncology Reports 31, no. 1 (2014): 335-341. https://doi.org/10.3892/or.2013.2858
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