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Article

Clinical significance of TrkB expression in nasopharyngeal carcinoma

  • Authors:
    • Shi-Sheng Li
    • Jia-Jia Liu
    • Shuang Wang
    • Qing-Lai Tang
    • Bing-Bing Liu
    • Xin-Ming Yang
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China
  • Pages: 665-672
    |
    Published online on: November 28, 2013
       https://doi.org/10.3892/or.2013.2878
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Abstract

Recent research has demonstrated that tropomyosin‑related kinase B (TrkB) plays an important role in neuronal survival, differentiation and migration; yet, its specific role in human nasopharyngeal carcinoma (NPC) is unclear. To elucidate its role in NPC, we examined TrkB expression in NPC tissues and cell lines, and investigated the correlation between TrkB expression and prognosis in patients with NPC. Immunohistochemical analysis was performed on NPC specimens from 108 patients with follow-up information. Additionally, reverse transcriptase-polymerase chain reaction (RT-PCR) and western blot analyses were used to determine TrkB expression levels in NPC and noncancerous nasopharyngeal tissues. RT-PCR and western blot analyses were also used to determine TrkB expression levels in 7 NPC cell lines and a nasopharyngeal epithelium cell line. High TrkB expression was significantly correlated with T classification, lymph node metastasis and clinical stage, respectively. Patients with NPC who had high TrkB expression had reduced disease-free survival and overall survival when compared with patients who had low TrkB expression. Multivariate Cox regression analysis revealed that TrkB overexpression was an independent prognostic factor for patients with NPC. Furthermore, TrkB was overexpressed in NPC specimens and cell lines. TrkB expression levels were significantly increased in NPC specimens, and enhanced levels were correlated with a poor prognosis in patients with NPC. These findings suggest that TrkB may contribute to NPC progression and represent a novel prognostic indicator for patients with NPC.
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1 

Tang L, Mao Y, Liu L, et al: The volume to be irradiated during selective neck irradiation in nasopharyngeal carcinoma: analysis of the spread patterns in lymph nodes by magnetic resonance imaging. Cancer. 115:680–688. 2009.

2 

Agulnik M and Siu LL: State-of-the-art management of nasopharyngeal carcinoma: current and future directions. Br J Cancer. 92:799–806. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Caponigro F, Longo F, Ionna F and Perri F: Treatment approaches to nasopharyngeal carcinoma: a review. Anticancer Drugs. 21:471–477. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Chang ET and Adami HO: The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 15:1765–1777. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Brodeur GM, Minturn JE, Ho R, et al: Trk receptor expression and inhibition in neuroblastomas. Clin Cancer Res. 15:3244–3250. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Schramm A, Schulte JH, Astrahantseff K, et al: Biological effects of TrkA and TrkB receptor signaling in neuroblastoma. Cancer Lett. 228:143–153. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Ricci A, Greco S, Mariotta S, et al: Neurotrophins and neurotrophin receptors in human lung cancer. Am J Respir Cell Mol Biol. 25:439–446. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Sclabas GM, Fujioka S, Schmidt C, et al: Overexpression of tropomysin-related kinase B in metastatic human pancreatic cancer cells. Clin Cancer Res. 11:440–449. 2005.PubMed/NCBI

9 

Zhang Y, Fujiwara Y, Doki Y, et al: Overexpression of tyrosine kinase B protein as a predictor for distant metastases and prognosis in gastric carcinoma. Oncology. 75:17–26. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Yu X, Liu L, Cai B, He Y and Wan X: Suppression of anoikis by the neurotrophic receptor TrkB in human ovarian cancer. Cancer Sci. 99:543–552. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Yu Y, Zhang S, Wang X, Yang Z and Ou G: Overexpression of TrkB promotes the progression of colon cancer. APMIS. 118:188–195. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Yao KT, Zhang HY, Zhu HC, et al: Establishment and characterization of two epithelial tumor cell lines (HNE-1 and HONE-1) latently infected with Epstein-Barr virus and derived from nasopharyngeal carcinomas. Int J Cancer. 45:83–89. 1990. View Article : Google Scholar : PubMed/NCBI

13 

Cheung ST, Huang DP, Hui AB, et al: Nasopharyngeal carcinoma cell line (C666-1) consistently harbouring Epstein-Barr virus. Int J Cancer. 83:121–126. 1999. View Article : Google Scholar : PubMed/NCBI

14 

Li J, Fan Y, Chen J, Yao KT and Huang ZX: Microarray analysis of differentially expressed genes between nasopharyngeal carcinoma cell lines 5–8F and 6–10B. Cancer Genet Cytogenet. 196:23–30. 2010.

15 

Tsao SW, Wang X, Liu Y, et al: Establishment of two immortalized nasopharyngeal epithelial cell lines using SV40 large T and HPV16E6/E7 viral oncogenes. Biochim Biophys Acta. 1590:150–158. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Chan AT, Teo PM, Ngan RK, et al: Concurrent chemotherapy-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: progression-free survival analysis of a phase III randomized trial. J Clin Oncol. 20:2038–2044. 2002. View Article : Google Scholar

17 

Xu T, Hu C, Wang X and Shen C: Role of chemoradiotherapy in intermediate prognosis nasopharyngeal carcinoma. Oral Oncol. 47:408–413. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Chen MK, Yang SF, Lai JC, et al: Expression of bcl-2 correlates with poor prognosis and modulates migration of nasopharyngeal carcinoma cells. Clin Chim Acta. 411:400–405. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Casaletto JB and McClatchey AI: Spatial regulation of receptor tyrosine kinases in development and cancer. Nat Rev Cancer. 411:387–400. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Shimizu M, Adachi S, Masuda M, Kozawa O and Moriwaki H: Cancer chemoprevention with green tea catechins by targeting receptor tyrosine kinases. Mol Nutr Food Res. 55:832–843. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Edsjö A, Lavenius E, Nilsson H, et al: Expression of TrkB in human neuroblastoma in relation to MYCN expression and retinoic acid treatment. Lab Invest. 83:813–823. 2003.PubMed/NCBI

22 

Eggert A, Ikegaki N, Liu XG and Brodeur GM: Prognostic and biological role of neurotrophin-receptor TrkA and TrkB in neuroblastoma. Klin Padiatr. 212:200–205. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Miknyoczki SJ, Lang D, Huang L, Klein-Szanto AJ, Dionne CA and Ruggeri BA: Neurotrophins and Trk receptors in human pancreatic ductal adenocarcinoma: expression patterns and effects on in vitro invasive behavior. Int J Cancer. 81:417–427. 1999. View Article : Google Scholar : PubMed/NCBI

24 

Desmet CJ and Peeper DS: The neurotrophic receptor TrkB: a drug target in anti-cancer therapy? Cell Mol Life Sci. 63:755–759. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Geiger TR and Peeper DS: The neurotrophic receptor TrkB in anoikis resistance and metastasis: a perspective. Cancer Res. 65:7033–7036. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Kupferman ME, Jiffar T, El-Naggar A, et al: TrkB induces EMT and has a key role in invasion of head and neck squamous cell carcinoma. Oncogene. 29:2047–2059. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Okamura K, Harada T, Wang S, et al: Expression of TrkB and BDNF is associated with poor prognosis in non-small cell lung cancer. Lung Cancer. 78:100–106. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Fujikawa H, Tanaka K, Toiyama Y, et al: High TrkB expression levels are associated with poor prognosis and EMT induction in colorectal cancer cells. J Gastroenterol. 47:775–784. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Perez-Pinera P, Hernandez T, García-Suárez O, et al: The Trk tyrosine kinase inhibitor K252a regulates growth of lung adenocarcinomas. Mol Cell Biochem. 295:19–26. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li S, Liu J, Wang S, Tang Q, Liu B and Yang X: Clinical significance of TrkB expression in nasopharyngeal carcinoma. Oncol Rep 31: 665-672, 2014.
APA
Li, S., Liu, J., Wang, S., Tang, Q., Liu, B., & Yang, X. (2014). Clinical significance of TrkB expression in nasopharyngeal carcinoma. Oncology Reports, 31, 665-672. https://doi.org/10.3892/or.2013.2878
MLA
Li, S., Liu, J., Wang, S., Tang, Q., Liu, B., Yang, X."Clinical significance of TrkB expression in nasopharyngeal carcinoma". Oncology Reports 31.2 (2014): 665-672.
Chicago
Li, S., Liu, J., Wang, S., Tang, Q., Liu, B., Yang, X."Clinical significance of TrkB expression in nasopharyngeal carcinoma". Oncology Reports 31, no. 2 (2014): 665-672. https://doi.org/10.3892/or.2013.2878
Copy and paste a formatted citation
x
Spandidos Publications style
Li S, Liu J, Wang S, Tang Q, Liu B and Yang X: Clinical significance of TrkB expression in nasopharyngeal carcinoma. Oncol Rep 31: 665-672, 2014.
APA
Li, S., Liu, J., Wang, S., Tang, Q., Liu, B., & Yang, X. (2014). Clinical significance of TrkB expression in nasopharyngeal carcinoma. Oncology Reports, 31, 665-672. https://doi.org/10.3892/or.2013.2878
MLA
Li, S., Liu, J., Wang, S., Tang, Q., Liu, B., Yang, X."Clinical significance of TrkB expression in nasopharyngeal carcinoma". Oncology Reports 31.2 (2014): 665-672.
Chicago
Li, S., Liu, J., Wang, S., Tang, Q., Liu, B., Yang, X."Clinical significance of TrkB expression in nasopharyngeal carcinoma". Oncology Reports 31, no. 2 (2014): 665-672. https://doi.org/10.3892/or.2013.2878
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