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Article

Relapse-associated microRNA in gastric cancer patients after S-1 adjuvant chemotherapy

  • Authors:
    • Tetsuya Omura
    • Yutaka Shimada
    • Takuya Nagata
    • Tomoyuki Okumura
    • Junya Fukuoka
    • Fuminori Yamagishi
    • Sadakatsu Tajika
    • Sanae Nakajima
    • Atsushi Kawabe
    • Kazuhiro Tsukada
  • View Affiliations / Copyright

    Affiliations: Department of Surgery and Science, University of Toyama, Toyama 930‑0194, Japan, Department of Surgical Pathology, University of Toyama, Toyama 930‑0194, Japan, Department of Surgery, Itoigawa General Hospital, Itoigawa, Niigata 941-8502, Japan, Department of Surgery, Saiseikai Toyama Hospital, Toyama 931-8533, Japan, Department of Surgery, Murakami Memorial Hospital, Asahi University, Gifu 500-8523, Japan
  • Pages: 613-618
    |
    Published online on: December 5, 2013
       https://doi.org/10.3892/or.2013.2900
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Abstract

S-1 has been recommended as adjuvant chemotherapy in patients after curative surgery for gastric cancer. However, some patients suffer recurrence even after S-1 adjuvant chemotherapy. The present study was conducted to find a predictive marker of the efficacy of S-1 adjuvant chemotherapy. We examined the microRNA (miRNA) expression of 35 patients who underwent S-1 adjuvant chemotherapy after curative surgery (R0) for pathological stage II or III gastric cancer. miRNAs were extracted from formalin-fixed, paraffin-embedded specimens for analysis and miRNA expression was examined using miRNA oligo chips. Fifteen patients relapsed and 20 did not over 5 years. Five miRNAs (miR-92b, 422a, 4732-5p, 4758-3p and 221) were highly expressed according to the tumor/normal (T/N) ratio in the patients who relapsed but not in those who did not relapse (P-value <0.05) by microarray analysis. If tumors showed high expression of 4 miRNAs (miR-92b, 422a, 4732-5p and 4758-3p) their positive predictive value of relapse was 93.8% and negative predictive value was 92.3%. In this case, their disease-free survival rate and overall survival rate were very poor. Our findings indicate that miR-92b, miR‑422a, miR-4732-5p and miR-4758-3p are closely associated with relapse following S-1 adjuvant chemotherapy in gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Omura T, Shimada Y, Nagata T, Okumura T, Fukuoka J, Yamagishi F, Tajika S, Nakajima S, Kawabe A, Tsukada K, Tsukada K, et al: Relapse-associated microRNA in gastric cancer patients after S-1 adjuvant chemotherapy. Oncol Rep 31: 613-618, 2014.
APA
Omura, T., Shimada, Y., Nagata, T., Okumura, T., Fukuoka, J., Yamagishi, F. ... Tsukada, K. (2014). Relapse-associated microRNA in gastric cancer patients after S-1 adjuvant chemotherapy. Oncology Reports, 31, 613-618. https://doi.org/10.3892/or.2013.2900
MLA
Omura, T., Shimada, Y., Nagata, T., Okumura, T., Fukuoka, J., Yamagishi, F., Tajika, S., Nakajima, S., Kawabe, A., Tsukada, K."Relapse-associated microRNA in gastric cancer patients after S-1 adjuvant chemotherapy". Oncology Reports 31.2 (2014): 613-618.
Chicago
Omura, T., Shimada, Y., Nagata, T., Okumura, T., Fukuoka, J., Yamagishi, F., Tajika, S., Nakajima, S., Kawabe, A., Tsukada, K."Relapse-associated microRNA in gastric cancer patients after S-1 adjuvant chemotherapy". Oncology Reports 31, no. 2 (2014): 613-618. https://doi.org/10.3892/or.2013.2900
Copy and paste a formatted citation
x
Spandidos Publications style
Omura T, Shimada Y, Nagata T, Okumura T, Fukuoka J, Yamagishi F, Tajika S, Nakajima S, Kawabe A, Tsukada K, Tsukada K, et al: Relapse-associated microRNA in gastric cancer patients after S-1 adjuvant chemotherapy. Oncol Rep 31: 613-618, 2014.
APA
Omura, T., Shimada, Y., Nagata, T., Okumura, T., Fukuoka, J., Yamagishi, F. ... Tsukada, K. (2014). Relapse-associated microRNA in gastric cancer patients after S-1 adjuvant chemotherapy. Oncology Reports, 31, 613-618. https://doi.org/10.3892/or.2013.2900
MLA
Omura, T., Shimada, Y., Nagata, T., Okumura, T., Fukuoka, J., Yamagishi, F., Tajika, S., Nakajima, S., Kawabe, A., Tsukada, K."Relapse-associated microRNA in gastric cancer patients after S-1 adjuvant chemotherapy". Oncology Reports 31.2 (2014): 613-618.
Chicago
Omura, T., Shimada, Y., Nagata, T., Okumura, T., Fukuoka, J., Yamagishi, F., Tajika, S., Nakajima, S., Kawabe, A., Tsukada, K."Relapse-associated microRNA in gastric cancer patients after S-1 adjuvant chemotherapy". Oncology Reports 31, no. 2 (2014): 613-618. https://doi.org/10.3892/or.2013.2900
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