Allograft inflammatory factor-1 is an independent prognostic indicator that regulates β-catenin in gastric cancer

Ye,Yang; Miao,Shuhan; Lu,Rongzhu; Xia,Xiaowei; Chen,Yansu; Zhang,Jianbing; Wu,Xuming; He,Song; Qiang,Fulin; Zhou,Jianwei

doi:10.3892/or.2013.2915

Allograft inflammatory factor-1 is an independent prognostic indicator that regulates β-catenin in gastric cancer

Authors:
- Yang Ye
- Shuhan Miao
- Rongzhu Lu
- Xiaowei Xia
- Yansu Chen
- Jianbing Zhang
- Xuming Wu
- Song He
- Fulin Qiang
- Jianwei Zhou
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Affiliations: Department of Preventive Medicine, School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China, Department of Molecular Cell Biology and Toxicology, Cancer Center, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Pathology, Nantong Cancer Hospital, Nantong, Jiangsu 226361, P.R. China
Published online on: December 12, 2013 https://doi.org/10.3892/or.2013.2915
Pages: 828-834

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Abstract

Previous studies have revealed that expression of allograft inflammatory factor-1 (AIF-1) protein appears to be increased in malignancies and is correlated with a poorer prognosis in cervical cancer, while its role in gastric cancer has not been reported. We analyzed the expression of AIF-1 in 78 cancer lesions and the corresponding non-cancerous tissues by immunohistochemistry. In contrast with other cancers, we found that AIF-1 protein levels were significantly decreased in 53 of the 78 (67.9%) gastric cancer tissues when compared with the matched normal tissues. This was further confirmed using 7 pairs of fresh gastric cancer tissues and matched adjacent normal tissues. Low tumoral AIF-1 expression was significantly correlated with less favorable clinicopathological characteristics, as well as with reduced overall survival (P<0.001) in the gastric cancer patients. Furthermore, knockdown of AIF-1 obviously increased proliferation, migration and β-catenin expression in BGC-823 and SGC-7901 gastric cancer cells. Taken together, for the first time, we provide evidence that the level of AIF-1 expression may serve as a protective prognostic indicator for gastric cancer.

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