Expression of fatty acid binding protein 4 is involved in the cell growth of oral squamous cell carcinoma

Lee,Doksa; Wada,Koichiro; Taniguchi,Yoshitaka; Al-Shareef,Hani; Masuda,Tomotake; Usami,Yu; Aikawa,Tomonao; Okura,Masaya; Kamisaki,Yoshinori; Kogo,Mikihiko

doi:10.3892/or.2014.2975

2014-March Volume 31 Issue 3

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2014-March Volume 31 Issue 3

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Article

Expression of fatty acid binding protein 4 is involved in the cell growth of oral squamous cell carcinoma

Authors:
- Doksa Lee
- Koichiro Wada
- Yoshitaka Taniguchi
- Hani Al-Shareef
- Tomotake Masuda
- Yu Usami
- Tomonao Aikawa
- Masaya Okura
- Yoshinori Kamisaki
- Mikihiko Kogo
View Affiliations / Copyright

Affiliations: First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, Suita, Osaka 565-0871, Japan, Department of Pharmacology, Graduate School of Dentistry, Osaka University, Suita, Osaka 565-0871, Japan, Clinical Laboratory, Osaka University Dental Hospital, Suita, Osaka 565-0871, Japan
Pages: 1116-1120
|
Published online on: January 13, 2014

https://doi.org/10.3892/or.2014.2975
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Abstract

Fatty acid binding proteins (FABPs) are a family of small and highly conserved lipid chaperone molecules with highly varied functions. Among them, fatty acid binding protein 4 (FABP4, also known as aP2) is highly expressed by adipocytes, macrophages and dendritic cells. Although the role of FABP4 in cancer is still unclear, it has been reported to be highly expressed by human tumors such as ovarian and bladder cancers. In the present study, we investigated the expression and role of FABP4 in oral squamous cell carcinoma (SCC) and its expression in oral SCC tissues. Immunohistochemical staining revealed that FABP4 expression in the tumor tissue was much higher than that in the non-tumor area of the same specimen. In the in vitro studies, an FABP4-knockdown SCC cell line (established through FABP4-specific siRNA) showed inhibited growth, and inhibited expression and activation of mitogen-activated protein kinase (MAPK). These results indicate that expression of FABP4 plays an important role in the cell growth of oral SCC through the MAPK pathway.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Expression of fatty acid binding protein 4 is involved in the cell growth of oral squamous cell carcinoma

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