Journal Articles

Open Access

Thyroid tumor-initiating cells: Increasing evidence and opportunities for anticancer therapy (Review)

Yong-Ju Gao, Bo Li, Xin-Yu Wu, Jing Cui, Jian-Kui Han

Pages: 1035-1042 Published online on: 14 January 2014
Open Access

High throughput RNAi screening identifies ID1 as a synthetic sick/lethal gene interacting with the common TP53 mutation R175H

Hiroo Imai, Shunsuke Kato, Yasuhiro Sakamoto, Yuichi Kakudo, Hideki Shimodaira, Chikashi Ishioka

Pages: 1043-1050 Published online on: 30 December 2013
Open Access

Identification of HLA-A2 or HLA-A24-restricted CTL epitopes for potential HSP105-targeted immunotherapy in colorectal cancer

Yu Sawada, Hiroyuki Komori, Yoshiyuki Tsunoda, Manami Shimomura, Mari Takahashi, Hideo Baba, Masaaki Ito, Norio Saito, Hiroyuki Kuwano, Itaru Endo, Yasuharu Nishimura, Tetsuya Nakatsura

Pages: 1051-1058 Published online on: 20 December 2013
Open Access

Ten-year follow-up of a prospective trial for the targeted therapy of gastric cancer with the human monoclonal antibody PAT-SC1

Frank Hensel, Wolfgang Timmermann, Burkhard H.A. von Rahden, Andreas Rosenwald, Stephanie Brändlein, Bertram Illert

Pages: 1059-1066 Published online on: 20 January 2014
Open Access

Comprehensive microRNA profiling of prostate cancer cells after ionizing radiation treatment

Chung-Man Leung, Sung-Chou Li, Ting-Wen Chen, Meng-Ru Ho, Ling-Yueh Hu, Wen‑Shan Liu, Tony T. Wu, Ping-Chi Hsu, Hong-Tai Chang, Kuo-Wang Tsai

Pages: 1067-1078 Published online on: 21 January 2014
Open Access

Analysis of the B-RafV600E mutation in cutaneous melanoma patients with occupational sun exposure

Saverio Candido, Venerando Rapisarda, Andrea Marconi, Grazia Malaponte, Valentina Bevelacqua, Pietro Gangemi, Aurora Scalisi, James A. McCubrey, Roberta Maestro, Demetrios A. Spandidos, Concettina Fenga, Massimo Libra

Pages: 1079-1082 Published online on: 14 January 2014
Open Access

Preoperative hepatic CT perfusion as an early predictor for the recurrence of esophageal squamous cell carcinoma: Initial clinical results

Takeshi Fujishiro, Kiyohiko Shuto, Koichi Hayano, Asami Satoh, Tsuguaki Kono, Gaku Ohira, Takayuki Tohma, Hisashi Gunji, Kazuo Narushima, Toru Tochigi, Toshiharu Hanaoka, Sayaka Ishii, Noriyuki Yanagawa, Hisahiro Matsubara

Pages: 1083-1088 Published online on: 22 January 2014
Open Access

A novel gene expression system strongly enhances the anticancer effects of a REIC/Dkk-3-encoding adenoviral vector

Masami Watanabe, Masakiyo Sakaguchi, Rie Kinoshita, Haruki Kaku, Yuichi Ariyoshi, Hideo Ueki, Ryuta Tanimoto, Shin Ebara, Kazuhiko Ochiai, Junichiro Futami, Shun-Ai Li, Peng Huang, Yasutomo Nasu, Nam-Ho Huh, Hiromi Kumon

Pages: 1089-1095 Published online on: 31 December 2013
Open Access

MicroRNA-195-5p is a potential diagnostic and therapeutic target for breast cancer

Qifeng Luo, Chuankui Wei, Xiaoyu Li, Jia Li, Lei Chen, Yixiang Huang, Hongming Song, Dengfeng Li, Lin Fang

Pages: 1096-1102 Published online on: 08 January 2014

pp32r1 controls the decay of the RNA-binding protein HuR

Kenji Imamachi, Fumihiro Higashino, Tetsuya Kitamura, Wataru Kakuguchi, Aya Yanagawa-Matsuda, Makoto Ishikawa, Yoshimasa Kitagawa, Yasunori Totsuka, Masanobu Shindoh

Pages: 1103-1108 Published online on: 31 December 2013

Antitumor effect and antiangiogenic potential of the mTOR inhibitor temsirolimus against malignant pleural mesothelioma

Makio Moriya, Tadaaki Yamada, Masaya Tamura, Daisuke Ishikawa, Mir Alireza Hoda, Isao Matsumoto, Walter Klepetko, Makoto Oda, Seiji Yano, Go Watanabe

Pages: 1109-1115 Published online on: 30 December 2013

Expression of fatty acid binding protein 4 is involved in the cell growth of oral squamous cell carcinoma

Doksa Lee, Koichiro Wada, Yoshitaka Taniguchi, Hani Al-Shareef, Tomotake Masuda, Yu Usami, Tomonao Aikawa, Masaya Okura, Yoshinori Kamisaki, Mikihiko Kogo

Pages: 1116-1120 Published online on: 13 January 2014

Glycan profiling of gestational choriocarcinoma using a lectin microarray

Yusuke Kobayashi, Kenta Masuda, Kouji Banno, Nana Kobayashi, Kiyoko Umene, Yuya Nogami, Kosuke Tsuji, Arisa Ueki, Hiroyuki Nomura, Kenji Sato, Eiichiro Tominaga, Takatsune Shimizu, Hideyuki Saya, Daisuke Aoki

Pages: 1121-1126 Published online on: 14 January 2014

The role of CD44+/CD24-/low biomarker for screening, diagnosis and monitoring of breast cancer

Rosa Camerlingo, Giuseppe Andrea Ferraro, Francesco De Francesco, Maurizio Romano, Gianfranco Nicoletti, Maurizio Di Bonito, Massimo Rinaldo, Francesco D'Andrea, Giuseppe Pirozzi

Pages: 1127-1132 Published online on: 23 December 2013

Novel drug discovery system for cancer stem cells in human squamous cell carcinoma of the esophagus

Yoshihiro Kano, Masamitsu Konno, Koichi Kawamoto, Keisuke Tamari, Kazuhiko Hayashi, Takahito Fukusumi, Taroh Satoh, Shinji Tanaka, Kazuhiko Ogawa, Masaki Mori, Yuichiro Doki, Hideshi Ishii

Pages: 1133-1138 Published online on: 30 December 2013

Upregulation of E2F transcription factor 3 is associated with poor prognosis in hepatocellular carcinoma

Xiaoyun Zeng, Fuqiang Yin, Xia Liu, Jianwen Xu, Yang Xu, Jinmei Huang, Yueli Nan, Xiaoqiang Qiu

Pages: 1139-1146 Published online on: 08 January 2014

Human osteosarcoma cells respond to sorafenib chemotherapy by downregulation of the tumor progression factors S100A4, CXCR4 and the oncogene FOS

Ingrid Walter, Birgitt Wolfesberger, Ingrid Miller, Georg Mair, Stefanie Burger, Birgit Gallè, Ralf Steinborn

Pages: 1147-1156 Published online on: 30 December 2013

Upregulation of miR-194 contributes to tumor growth and progression in pancreatic ductal adenocarcinoma

Jing Zhang, Chen-Yan Zhao, Shu-Hui Zhang, Dang-Hui Yu, Ying Chen, Qing-Hua Liu, Min Shi, Can-Rong Ni, Ming-Hua Zhu

Pages: 1157-1164 Published online on: 31 December 2013

Vandetanib-induced inhibition of neuroblastoma cell migration and invasion is associated with downregulation of the SDF-1/CXCR4 axis and matrix metalloproteinase 14

Xionghui Ding, Li Xiang, Ning Wang, Zhanbo Zhao, Xin Jin, Yanhui Sun, Wenjuan Duan, Shiqi Wang, Xianqing Jin

Pages: 1165-1174 Published online on: 31 December 2013

Overexpression of AIOLOS inhibits cell proliferation and suppresses apoptosis in Nalm-6 cells

Yong Zhuang, Dong Li, Jinqiu Fu, Qing Shi, Yuanyuan Lu, Xiuli Ju

Pages: 1183-1190 Published online on: 31 December 2013

Overexpression of B7-H1 correlates with malignant cell proliferation in pancreatic cancer

Xiao Song, Junwei Liu, Yi Lu, Hongchuan Jin, Dongsheng Huang

Pages: 1191-1198 Published online on: 31 December 2013

Significance of the vascular endothelial growth factor and the macrophage migration inhibitory factor in the progression of hepatocellular carcinoma

Dong Wang, Liang Luo, Wei Chen, Lian-Zhou Chen, Wen-Tao Zeng, Wen Li, Xiao-Hui Huang

Pages: 1199-1204 Published online on: 23 December 2013

PGC-1α integrates glucose metabolism and angiogenesis in multiple myeloma cells by regulating VEGF and GLUT-4

Dedong Cao, Hao Zhou, Jikai Zhao, Lu Jin, Wen Yu, Han Yan, Yu Hu, Tao Guo

Pages: 1205-1210 Published online on: 09 January 2014

Analysis of SEMA3B methylation and expression patterns in gastric cancer tissue and cell lines

Renpin Chen, Xiaoju Zhuge, Zhiming Huang, Deyi Lu, Xiaohua Ye, Chao Chen, Jieyu Yu, Guangrong Lu

Pages: 1211-1218 Published online on: 09 January 2014

A novel somatic FGFR3 mutation in primary lung cancer

Kazuya Shinmura, Hisami Kato, Shun Matsuura, Yusuke Inoue, Hisaki Igarashi, Kiyoko Nagura, Satoki Nakamura, Kyoko Maruyama, Mari Tajima, Kazuhito Funai, Hiroshi Ogawa, Masayuki Tanahashi, Hiroshi Niwa, Haruhiko Sugimura

Pages: 1219-1224 Published online on: 20 January 2014

Forkhead-box A1 suppresses the progression of endometrial cancer via crosstalk with estrogen receptor α

Jingyun Wang, Wei Bao, Meiting Qiu, Yun Liao, Qi Che, Tingting Yang, Xiaoying He, Haifeng Qiu, Xiaoping Wan

Pages: 1225-1234 Published online on: 20 January 2014

Ovarian cancer stem cell-specific gene expression profiling and targeted drug prescreening

Yuting Huang, Baohui Ju, Jing Tian, Fenghua Liu, Hu Yu, Huiting Xiao, Xiangyu Liu, Wenxin Liu, Zhi Yao, Quan Hao

Pages: 1235-1248 Published online on: 13 January 2014

Silencing of Aurora kinase A by RNA interference inhibits tumor growth in human osteosarcoma cells by inducing apoptosis and G2/M cell cycle arrest

Zhenhuan Jiang, Jiannong Jiang, Huilin Yang, Zhijun Ge, Qiang Wang, Leiyan Zhang, Chenguang Wu, Jinzhi Wang

Pages: 1249-1254 Published online on: 20 January 2014

miR-222 regulates the cell biological behavior of oral squamous cell carcinoma by targeting PUMA

Fangfang Jiang, Wei Zhao, Lijie Zhou, Lin Zhang, Zifeng Liu, Dongsheng Yu

Pages: 1255-1262 Published online on: 20 January 2014

Downregulation of microRNA-26a is associated with metastatic potential and the poor prognosis of osteosarcoma patients

Qi-Chun Song, Zhi-Bin Shi, Yong-Tao Zhang, Le Ji, Kun‑Zheng Wang, Da-Peng Duan, Xiao-Qian Dang

Pages: 1263-1270 Published online on: 21 January 2014

Downregulation of NOB1 suppresses the proliferation and tumor growth of non-small cell lung cancer in vitro and in vivo Retraction in /10.3892/or.2020.7483

Yang Li, Chengyuan Ma, Ming Qian, Zhongmei Wen, Hongyu Jing, Donghua Qian

Pages: 1271-1276 Published online on: 21 January 2014

Expression profiles of 507 proteins from a biotin label-based antibody array in human colorectal cancer

Hisaaki Miyoshi, Asahiro Morishita, Joji Tani, Teppei Sakamoto, Koji Fujita, Akiko Katsura, Miwa Tatsuta, Takako Nomura, Hirohito Yoneyama, Hisakazu Iwama, Yasuyuki Suzuki, Tsutomu Masaki

Pages: 1277-1281 Published online on: 19 December 2013

The heme precursor 5-aminolevulinic acid disrupts the Warburg effect in tumor cells and induces caspase-dependent apoptosis

Yuta Sugiyama, Yuichiro Hagiya, Motowo Nakajima, Masahiro Ishizuka, Tohru Tanaka, Shun-Ichiro Ogura

Pages: 1282-1286 Published online on: 23 December 2013

Intratumoral expression of mature human neutrophil peptide-1 potentiates the therapeutic effect of doxorubicin in a mouse 4T1 breast cancer model

Dan Li, Qing Qin, Xiao-Yi Wang, Hua-Shan Shi, Min Luo, Fu-Chun Guo, Wei Wang, Yong-Sheng Wang

Pages: 1287-1295 Published online on: 30 December 2013

Overexpression of transferrin receptor CD71 and its tumorigenic properties in esophageal squamous cell carcinoma

Kin Tak Chan, Mei Yuk Choi, Kenneth K.Y. Lai, Winnie Tan, Lai Nar Tung, Ho Yu Lam, Daniel K.H. Tong, Nikki P. Lee, Simon Law

Pages: 1296-1304 Published online on: 16 January 2014

Identification of intragenic methylation in the TUSC1 gene as a novel prognostic marker of hepatocellular carcinoma

Dai Shimizu, Mitsuro Kanda, Shuji Nomoto, Hisaharu Oya, Hideki Takami, Soki Hibino, Masaya Suenaga, Yoshikuni Inokawa, Mitsuhiro Hishida, Nao Takano, Yoko Nishikawa, Suguru Yamada, Tsutomu Fujii, Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Michitaka Fujiwara, Yasuhiro Kodera

Pages: 1305-1313 Published online on: 20 December 2013

siRNA-mediated knockdown of hTDE2 retards cell cycle progression through transcriptional activation of p21

Wei-Hua Ren, Chen-Yi Yang, Xian-Mei Yang, Long Yu

Pages: 1314-1322 Published online on: 14 January 2014

Overexpression of cysteine cathepsin L is a marker of invasion and metastasis in ovarian cancer

Wei Zhang, Sumei Wang, Qi Wang, Zhijun Yang, Zhongmian Pan, Li Li

Pages: 1334-1342 Published online on: 08 January 2014

Epigallocatechin gallate inhibits the growth of human lung cancer by directly targeting the EGFR signaling pathway

Yu-Chao Ma, Cui Li, Feng Gao, Yan Xu, Zhi-Bin Jiang, Jian-Xin Liu, Long-Yu Jin

Pages: 1343-1349 Published online on: 19 December 2013

Kaempferol induces cell cycle arrest and apoptosis in renal cell carcinoma through EGFR/p38 signaling

Wenbin Song, Qiang Dang, Defeng Xu, Yule Chen, Guodong Zhu, Kaijie Wu, Jin Zeng, Qingzhi Long, Xinyang Wang, Dalin He, Lei Li

Pages: 1350-1356 Published online on: 07 January 2014

miR-96 promotes tumor proliferation and invasion by targeting RECK in breast cancer

Junfeng Zhang, Xiangjie Kong, Jia Li, Qifeng Luo, Xiaoyu Li, Lei Shen, Lei Chen, Lin Fang

Pages: 1357-1363 Published online on: 19 December 2013

Latexin exhibits tumor suppressor potential in hepatocellular carcinoma

Qing-Feng Ni, Yuan Tian, Liang-Liang Kong, Ye-Ting Lu, Wen-Zhou Ding, Lian-Bao Kong

Pages: 1364-1372 Published online on: 08 January 2014

Ik6 expression provides a new strategy for the therapy of acute lymphoblastic leukemia

Fen Zhou, Yunyun Xu, Yining Qiu, Xiaoyan Wu, Zhiquan Zhang, Runming Jin

Pages: 1373-1379 Published online on: 08 January 2014

TWIST1 and SNAI1 as markers of poor prognosis in human colorectal cancer are associated with the expression of ALDH1 and TGF-β1

Yong Hun Kim, Gwangil Kim, Chang-Il Kwon, Jong Woo Kim, Pil Won Park, Ki-Baik Hahm

Pages: 1380-1388 Published online on: 08 January 2014

RPRD1B promotes tumor growth by accelerating the cell cycle in endometrial cancer

Yuan Wang, Haifeng Qiu, Weixu Hu, Shaoru Li, Jinjin Yu

Pages: 1389-1395 Published online on: 21 January 2014

Association of the p53 codon 72 polymorphism with clinicopathological characteristics of colorectal cancer through mRNA analysis

Ligia Petrolini De Oliveira, Ignacio López, Erika Maria Monteiro Dos Santos, Paula Tucci, Mónica Marín, Fernando Augusto Soares, Benedito Mauro Rossi, Renata De Almeida Coudry

Pages: 1396-1406 Published online on: 20 December 2013

Differential effects of erufosine on proliferation, wound healing and apoptosis in colorectal cancer cell lines

Ferda Kaleağasıoğlu, Martin R. Berger

Pages: 1407-1416 Published online on: 20 December 2013

Aberrant sialylation and fucosylation of intracellular proteins in cervical tissue are critical markers of cervical carcinogenesis

Hyoung Jin Kim, Seung Cheol Kim, Woong Ju, Yun Hwan Kim, Sun Young Yin, Hong-Jin Kim

Pages: 1417-1422 Published online on: 20 December 2013

Protein kinase C-α downregulates estrogen receptor-α by suppressing c-Jun phosphorylation in estrogen receptor-positive breast cancer cells

Sangmin Kim, Jeongmin Lee, Se Kyung Lee, Soo Youn Bae, Jiyoung Kim, Minkuk Kim, Won Ho Kil, Seok Won Kim, Jeong Eon Lee, Seok Jin Nam

Pages: 1423-1428 Published online on: 19 December 2013

miR-186, miR-3651 and miR-494: Potential biomarkers for oral squamous cell carcinoma extracted from whole blood

Jutta Ries, Eleftherios Vairaktaris, Abbas Agaimy, Rita Kintopp, Christoph Baran, Friedrich W. Neukam, Emeka Nkenke

Pages: 1429-1436 Published online on: 20 January 2014

Antitumor effect of adenoviral vector prime protein boost immunity targeting the MUC1 VNTRs

Yuqian Wang, Chenlu Liu, Qiu Xia, Peng Wang, Bo Li, Zhenzhen Lu, Jiaxi Sun, Hui Wu, Bin Yu, Jiaxin Wu, Xianghui Yu, Wei Kong, Haihong Zhang, Xianling Cong

Pages: 1437-1444 Published online on: 30 December 2013

MicroRNA-503 acts as a tumor suppressor in glioblastoma for multiple antitumor effects by targeting IGF-1R

Yingying Zhang, Xiong Chen, Haiwei Lian, Jianmiao Liu, Beiyan Zhou, Song Han, Biwen Peng, Jun Yin, Wanhong Liu, Xiaohua He

Pages: 1445-1452 Published online on: 30 December 2013

Antitumour effect of valproic acid against salivary gland cancer in vitro and in vivo

Hirokazu Nagai, Masako Fujioka-Kobayashi, Go Ohe, Kanae Hara, Natsumi Takamaru, Daisuke Uchida, Tetsuya Tamatani, Kenji Fujisawa, Youji Miyamoto

Pages: 1453-1458 Published online on: 31 December 2013

Post-transcriptional repression of FOXO1 by QKI results in low levels of FOXO1 expression in breast cancer cells

Fang Yu, Liang Jin, Guodong Yang, Lin Ji, Feng Wang, Zifan Lu

Pages: 1459-1465 Published online on: 31 December 2013

The role of plasma cell-free DNA detection in predicting preoperative chemoradiotherapy response in rectal cancer patients

W. Sun, Y. Sun, M. Zhu, Z. Wang, H. Zhang, Y. Xin, G. Jiang, X. Guo, Z. Zhang, Y. Liu

Pages: 1466-1472 Published online on: 30 December 2013

miR-511 induces the apoptosis of radioresistant lung adenocarcinoma cells by triggering BAX

Han-Han Zhang, Min Pang, Wei Dong, Jia-Xuan Xin, You-Jie Li, Zi-Cheng Zhang, Liang Yu, Ping-Yu Wang, Bao-Sheng Li, Shu-Yang Xie

Pages: 1473-1479 Published online on: 09 January 2014

Nicotine promotes cell proliferation and induces resistance to cisplatin by α7 nicotinic acetylcholine receptor‑mediated activation in Raw264.7 and El4 cells

Yan Yan Wang, Yao Liu, Xiao Yan Ni, Zhen Huan Bai, Qiong Yun Chen, Ye Zhang, Feng Guang Gao

Pages: 1480-1488 Published online on: 31 December 2013

DJ-1 is involved in the peritoneal metastasis of gastric cancer through activation of the Akt signaling pathway

Zheng-Ming Zhu, Zheng-Rong Li, Yan Huang, Hai-Hong Yu, Xiao-Shan Huang, Yu-Feng Yan, Jiang-Hua Shao, He-Ping Chen

Pages: 1489-1497 Published online on: 31 December 2013
Journal Cover

2014-March
Volume 31 Issue 3

Print ISSN: 1021-335X
Online ISSN: 1791-2431

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