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Article

Combining sorafenib with celecoxib synergistically inhibits tumor growth of non-small cell lung cancer cells in vitro and in vivo

  • Authors:
    • Hong Zhang
    • Zhihong Li
    • Kaizhong Wang
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, The First Hospital, Jilin University, Chaoyang, Changchun, Jilin 130021, P.R. China
  • Pages: 1954-1960
    |
    Published online on: February 18, 2014
       https://doi.org/10.3892/or.2014.3026
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Abstract

Although inhibition of cyclooxygenase-2 (COX-2) or the vascular endothelial growth factor receptor (VEGFR) has been shown to be a promising antitumor strategy in non-small cell lung cancer (NSCLC), the therapeutic efficacy is limited due to inherent tumor resistance. In the present study, we selected sorafenib (SOR), a VEGFR inhibitor, in combination with celecoxib (CXB), a COX-2 inhibitor, for suppressing tumor growth and simultaneously for reducing doses of both drugs for the treatment of NSCLC. The effects of SOR combined with CXB were examined in A549 cells (an NSCLC cell line). Assays of proliferation, apoptosis, cell cycle distribution and receptor signaling were performed. We found that treatment with the combination of low concentrations of SOR and CXB significantly suppressed the proliferation of A549 tumor cells in vitro and suppressed tumor growth in vivo when compared to the actions of either agent alone. The results also showed that the combination of SOR and CXB significantly increased the induction of apoptosis and decreased the expression of inhibitor of apoptosis genes, survivin and Bcl-2 (p<0.01). Furthermore, the combination treatment significantly suppressed constitutive phosphorylation of MEK and ERK, which may contribute to the inhibition of tumor growth. Taken together, our findings revealed that this additive combination of SOR and CXB is a potential drug candidate for the treatment of NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang H, Li Z and Wang K: Combining sorafenib with celecoxib synergistically inhibits tumor growth of non-small cell lung cancer cells in vitro and in vivo. Oncol Rep 31: 1954-1960, 2014.
APA
Zhang, H., Li, Z., & Wang, K. (2014). Combining sorafenib with celecoxib synergistically inhibits tumor growth of non-small cell lung cancer cells in vitro and in vivo. Oncology Reports, 31, 1954-1960. https://doi.org/10.3892/or.2014.3026
MLA
Zhang, H., Li, Z., Wang, K."Combining sorafenib with celecoxib synergistically inhibits tumor growth of non-small cell lung cancer cells in vitro and in vivo". Oncology Reports 31.4 (2014): 1954-1960.
Chicago
Zhang, H., Li, Z., Wang, K."Combining sorafenib with celecoxib synergistically inhibits tumor growth of non-small cell lung cancer cells in vitro and in vivo". Oncology Reports 31, no. 4 (2014): 1954-1960. https://doi.org/10.3892/or.2014.3026
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang H, Li Z and Wang K: Combining sorafenib with celecoxib synergistically inhibits tumor growth of non-small cell lung cancer cells in vitro and in vivo. Oncol Rep 31: 1954-1960, 2014.
APA
Zhang, H., Li, Z., & Wang, K. (2014). Combining sorafenib with celecoxib synergistically inhibits tumor growth of non-small cell lung cancer cells in vitro and in vivo. Oncology Reports, 31, 1954-1960. https://doi.org/10.3892/or.2014.3026
MLA
Zhang, H., Li, Z., Wang, K."Combining sorafenib with celecoxib synergistically inhibits tumor growth of non-small cell lung cancer cells in vitro and in vivo". Oncology Reports 31.4 (2014): 1954-1960.
Chicago
Zhang, H., Li, Z., Wang, K."Combining sorafenib with celecoxib synergistically inhibits tumor growth of non-small cell lung cancer cells in vitro and in vivo". Oncology Reports 31, no. 4 (2014): 1954-1960. https://doi.org/10.3892/or.2014.3026
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