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Article

Downregulation of microRNA-139 is associated with hepatocellular carcinoma risk and short-term survival

  • Authors:
    • Tao Li
    • Jikai Yin
    • Lijuan Yuan
    • Shouli Wang
    • Lin Yang
    • Xilin Du
    • Jianguo Lu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Tangdu Hospital of The Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China
  • Pages: 1699-1706
    |
    Published online on: February 19, 2014
       https://doi.org/10.3892/or.2014.3032
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Abstract

MicroRNAs (miRNAs) have been frequently reported to be diagnostic biomarkers and prognostic factors for cancer. The aim of the present study was to evaluate the clinical significance of microRNA-139 (miRNA-139) in hepatocellular carcinoma (HCC). All 31 patients enrolled in the present study had received curative hepatectomy. The objective miRNA was determined using miRNA microarray. The miRNA-139 expression level in cancerous tissue specimens was measured by means of reverse transcription and quantitative polymerase chain reaction, and compared with that in 31 corresponding peritumoral non-cancerous tissues. Plasma miRNA-139 expression was also quantified. The diagnostic value of plasma miRNA-139 for differentiating patients with HCC from the ones with chronic HBV-hepatitis (CH) was analyzed. The miRNA microarray performed in 3 pairs of tissue specimens determined miRNA-139 was downregulated (p=0.017). Compared with plasma of chronic HBV-hepatitis, miRNA-139 was lowly expressed in plasma of HCC patients (p<0.010). ROC analysis of plasma miRNA-139 yielded an AUC of 0.764 (p<0.010) with sensitivity of 80.6% and specificity of 58.1% while differentiating HCC from chronic HBV-hepatitis. The diagnostic power of serum α-fetoprotein (AFP) was also evaluated. The combination of miRNA-139 and AFP improved the differentiating power. Subsequently, 31 HCC patients were divided into the low or high expression group based on plasma miRNA-139 level. Plasma miRNA‑139 expression was correlated with serum AFP (p=0.043), Edmondson-Steiner grading (p=0.038). In addition, there was a significant difference in the 1-year survival rates between the two groups (p=0.023). miRNA‑139 was downregulated in the cancerous tissue and plasma of HCC patients. Plasma miRNA‑139 is a diagnostic biomarker and prognostic factor for HCC.
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1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar

2 

Srivatanakul P, Sriplung H and Deerasamee S: Epidemiology of liver cancer: an overview. Asian Pac J Cancer Prev. 5:118–125. 2004.

3 

Thorgeirsson SS and Grisham JW: Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet. 31:339–346. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Marrero JA and Lok AS: Newer markers for hepatocellular carcinoma. Gastroenterology. 127(Suppl 1): S113–S119. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Jannot G and Simard MJ: Tumour-related microRNAs functions in Caenorhabditis elegans. Oncogene. 25:6197–6201. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Lujambio A and Lowe SW: The microcosmos of cancer. Nature. 482:347–355. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Meng F, Henson R, Lang M, et al: Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. Gastroenterology. 130:2113–2129. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Xia L, Zhang D, Du R, et al: miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells. Int J Cancer. 123:372–379. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Budhu A, Jia HL, Forgues M, et al: Identification of metastasis-related microRNAs in hepatocellular carcinoma. Hepatology. 47:897–907. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Calin GA, Ferracin M, Cimmino A, et al: A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med. 353:1793–1801. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Luo X, Burwinkel B, Tao S and Brenner H: MicroRNA signatures: novel biomarker for colorectal cancer? Cancer Epidemiol Biomarkers Prev. 20:1272–1286. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative CT method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Marrero JA, Feng Z, Wang Y, et al: α-fetoprotein, des-γ carboxyprothrombin, and lectin-bound α-fetoprotein in early hepatocellular carcinoma. Gastroenterology. 137:110–118. 2009.

14 

Shih WL, Chang HC, Liaw YF, et al: Influences of tobacco and alcohol use on hepatocellular carcinoma survival. Int J Cancer. 131:2612–2621. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Edmondson HA and Steiner PE: Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer. 7:462–503. 1954. View Article : Google Scholar : PubMed/NCBI

16 

Child CG and Turcotte JG: Surgery and portal hypertension. Major Probl Clin Surg. 1:1–85. 1964.

17 

No authors listed. A new prognostic system for hepatocellular carcinoma: a retrospective study of 435 patients: the Cancer of the Liver Italian Program (CLIP) investigators. Hepatology. 28:751–755. 1998. View Article : Google Scholar : PubMed/NCBI

18 

Sherman M: Approaches to the diagnosis of hepatocellular carcinoma. Curr Gastroenterol Rep. 7:11–18. 2005. View Article : Google Scholar

19 

Forner A, Llovet JM and Bruix J: Hepatocellular carcinoma. Lancet. 379:1245–1255. 2012. View Article : Google Scholar

20 

Maluccio M and Covey A: Recent progress in understanding, diagnosing, and treating hepatocellular carcinoma. CA Cancer J Clin. 62:394–399. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Mitchell PS, Parkin RK, Kroh EM, et al: Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA. 105:10513–10518. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Lawrie CH, Gal S, Dunlop HM, et al: Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br J Haematol. 141:672–675. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Tomimaru Y, Eguchi H, Nagano H, et al: Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma. J Hepatol. 56:167–175. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Bao W, Fu HJ, Xie QS, et al: HER2 interacts with CD44 to up-regulate CXCR4 via epigenetic silencing of microRNA-139 in gastric cancer cells. Gastroenterology. 141:2076–2087. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Shen K, Liang Q, Xu K, et al: MiR-139 inhibits invasion and metastasis of colorectal cancer by targeting the type I insulin-like growth factor receptor. Biochem Pharmacol. 84:320–330. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Schmitz KJ, Helwig J, Bertram S, et al: Differential expression of microRNA-675, microRNA-139–3p and microRNA-335 in benign and malignant adrenocortical tumours. J Clin Pathol. 64:529–535. 2011.PubMed/NCBI

27 

Corbetta S, Vaira V, Guarnieri V, et al: Differential expression of microRNAs in human parathyroid carcinomas compared with normal parathyroid tissue. Endocr Relat Cancer. 17:135–146. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Wong TS, Liu XB, Wong BY, Ng RW, Yuen AP and Wei WI: Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue. Clin Cancer Res. 14:2588–2592. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Wong CC, Wong CM, Tung EK, et al: The microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by down-regulating Rho-kinase 2. Gastroenterology. 140:322–331. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Au SL, Wong CC, Lee JM, et al: Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis. Hepatology. 56:622–631. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Ker CG, Chen HY, Chen KS, et al: Clinical significance of cell differentiation in hepatocellular carcinoma. Hepatogastroenterology. 50:475–479. 2003.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li T, Yin J, Yuan L, Wang S, Yang L, Du X and Lu J: Downregulation of microRNA-139 is associated with hepatocellular carcinoma risk and short-term survival. Oncol Rep 31: 1699-1706, 2014.
APA
Li, T., Yin, J., Yuan, L., Wang, S., Yang, L., Du, X., & Lu, J. (2014). Downregulation of microRNA-139 is associated with hepatocellular carcinoma risk and short-term survival. Oncology Reports, 31, 1699-1706. https://doi.org/10.3892/or.2014.3032
MLA
Li, T., Yin, J., Yuan, L., Wang, S., Yang, L., Du, X., Lu, J."Downregulation of microRNA-139 is associated with hepatocellular carcinoma risk and short-term survival". Oncology Reports 31.4 (2014): 1699-1706.
Chicago
Li, T., Yin, J., Yuan, L., Wang, S., Yang, L., Du, X., Lu, J."Downregulation of microRNA-139 is associated with hepatocellular carcinoma risk and short-term survival". Oncology Reports 31, no. 4 (2014): 1699-1706. https://doi.org/10.3892/or.2014.3032
Copy and paste a formatted citation
x
Spandidos Publications style
Li T, Yin J, Yuan L, Wang S, Yang L, Du X and Lu J: Downregulation of microRNA-139 is associated with hepatocellular carcinoma risk and short-term survival. Oncol Rep 31: 1699-1706, 2014.
APA
Li, T., Yin, J., Yuan, L., Wang, S., Yang, L., Du, X., & Lu, J. (2014). Downregulation of microRNA-139 is associated with hepatocellular carcinoma risk and short-term survival. Oncology Reports, 31, 1699-1706. https://doi.org/10.3892/or.2014.3032
MLA
Li, T., Yin, J., Yuan, L., Wang, S., Yang, L., Du, X., Lu, J."Downregulation of microRNA-139 is associated with hepatocellular carcinoma risk and short-term survival". Oncology Reports 31.4 (2014): 1699-1706.
Chicago
Li, T., Yin, J., Yuan, L., Wang, S., Yang, L., Du, X., Lu, J."Downregulation of microRNA-139 is associated with hepatocellular carcinoma risk and short-term survival". Oncology Reports 31, no. 4 (2014): 1699-1706. https://doi.org/10.3892/or.2014.3032
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