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Article

Coexpression of ANXA2, SOD2 and HOXA13 predicts poor prognosis of esophageal squamous cell carcinoma

  • Authors:
    • Ruo-Lan Ma
    • Lu-Yan  Shen
    • Ke-Neng  Chen
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Surgery I, Peking University Cancer Hospital and Institute, Haidian, Beijing 100142, P.R. China
  • Pages: 2157-2164
    |
    Published online on: March 12, 2014
       https://doi.org/10.3892/or.2014.3088
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Abstract

Esophageal squamous cell carcinoma (ESCC) is the main type of esophageal cancer, and is the sixth leading cause of cancer-related mortality among all types of cancers. Previously, we found that the homeobox A13 gene (HOXA13) plays a crucial role in the carcinogenesis of ESCC and both Annexin A2 (ANXA2) and superoxide dismutase 2 (SOD2) were its potential targets. Samples from 258 patients from two independent cohorts were collected. RT-qPCR and immunohistochemistry (IHC) were used to detect the expression levels of HOXA13, ANXA2 and SOD2. Kaplan‑Meier survival curve analysis and Cox proportional hazards regression model were employed to determine their prognostic significance. Results showed that ESCC tissues had higher ANXA2 and SOD2 mRNA and protein levels than the non-cancerous tissues. ANXA2 and SOD2 were found to be positively correlated with HOXA13 expression not only at the mRNA level but also at the protein level. In both the study cohort and the validation cohort, the median overall survival time of patients with high expression of HOXA13, ANXA2 and SOD2 was shorter than the survival time of the patients with low expression. The Cox proportional hazards model revealed that both TNM stage and coexpression of HOXA13/ANXA2/SOD2 are independent predictors of overall survival of ESCC patients. In conclusion, the present study demonstrated that ANXA2 and SOD2 are potential target genes of HOXA13 and their coexpression predicts the poor prognosis of ESCC patients.
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Copy and paste a formatted citation
Spandidos Publications style
Ma R, Shen L and Chen K: Coexpression of ANXA2, SOD2 and HOXA13 predicts poor prognosis of esophageal squamous cell carcinoma. Oncol Rep 31: 2157-2164, 2014.
APA
Ma, R., Shen, L., & Chen, K. (2014). Coexpression of ANXA2, SOD2 and HOXA13 predicts poor prognosis of esophageal squamous cell carcinoma. Oncology Reports, 31, 2157-2164. https://doi.org/10.3892/or.2014.3088
MLA
Ma, R., Shen, L., Chen, K."Coexpression of ANXA2, SOD2 and HOXA13 predicts poor prognosis of esophageal squamous cell carcinoma". Oncology Reports 31.5 (2014): 2157-2164.
Chicago
Ma, R., Shen, L., Chen, K."Coexpression of ANXA2, SOD2 and HOXA13 predicts poor prognosis of esophageal squamous cell carcinoma". Oncology Reports 31, no. 5 (2014): 2157-2164. https://doi.org/10.3892/or.2014.3088
Copy and paste a formatted citation
x
Spandidos Publications style
Ma R, Shen L and Chen K: Coexpression of ANXA2, SOD2 and HOXA13 predicts poor prognosis of esophageal squamous cell carcinoma. Oncol Rep 31: 2157-2164, 2014.
APA
Ma, R., Shen, L., & Chen, K. (2014). Coexpression of ANXA2, SOD2 and HOXA13 predicts poor prognosis of esophageal squamous cell carcinoma. Oncology Reports, 31, 2157-2164. https://doi.org/10.3892/or.2014.3088
MLA
Ma, R., Shen, L., Chen, K."Coexpression of ANXA2, SOD2 and HOXA13 predicts poor prognosis of esophageal squamous cell carcinoma". Oncology Reports 31.5 (2014): 2157-2164.
Chicago
Ma, R., Shen, L., Chen, K."Coexpression of ANXA2, SOD2 and HOXA13 predicts poor prognosis of esophageal squamous cell carcinoma". Oncology Reports 31, no. 5 (2014): 2157-2164. https://doi.org/10.3892/or.2014.3088
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