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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
May-2014 Volume 31 Issue 5

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

LIM homeobox transcription factors, a novel subfamily which plays an important role in cancer (Review)

Xi Wang, Chao He, Xiaotong Hu
Pages: 1975-1985
Published online on: 27 March 2014

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Article

Clinical and biological impact of cyclin-dependent kinase subunit 2 in esophageal squamous cell carcinoma

Yoshiaki Kita, Yuka Nishizono, Hiroshi Okumura, Yasuto Uchikado, Ken Sasaki, Masataka Matsumoto, Tetsuro Setoyama, Kiyonori Tanoue, Itaru Omoto, Shinichiro Mori, Tetsuhiro Owaki, Sumiya Ishigami, Hiroshi Nakagawa, Fumiaki Tanaka, Koshi Mimori, Masaki Mori, Shoji Natsugoe
Pages: 1986-1992
Published online on: 05 March 2014

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Article Open Access

Upregulation of long non-coding RNA urothelial carcinoma associated 1 by CCAAT/enhancer binding protein α contributes to bladder cancer cell growth and reduced apoptosis

Mei Xue, Xu Li, Wenjing Wu, Shuwan Zhang, Shouzhen Wu, Zhengkun Li, Wei Chen
Pages: 1993-2000
Published online on: 19 March 2014

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Article

The BRCA2 gene is a potential molecular target during 5-fluorouracil therapy in human oral cancer cells

Yosuke Nakagawa, Atsuhisa Kajihara, Akihisa Takahashi, Natsuko Kondo, Eiichiro Mori, Tadaaki Kirita, Takeo Ohnishi
Pages: 2001-2006
Published online on: 11 March 2014

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Article

Non-invasive monitoring of anticancer effects of cisplatin on lung cancer in an orthotopic SCID mouse model using [18F] FDG PET-CT

Mohamed Mokhtar, Kazuya Kondo, Hiromitsu Takizawa, Tamaki Ohtani, Hideki Otsuka, Hitoshi Kubo, Koichiro Kajiura, Yasushi Nakagawa, Yukikiyo Kawakami, Mitsuteru Yoshida, Haruhiko Fujino, Shoji Sakiyama, Akira Tangoku
Pages: 2007-2014
Published online on: 05 March 2014

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Article

Nilotinib combined with interleukin-2 mediates antitumor and immunological effects in a B16 melanoma model

K. Geisler, A. Reischer, I. Kroeger, B. Jacobs, K. Meinhardt, R. Bauer, B. Ryffel, A. Mackensen, E. Ullrich
Pages: 2015-2020
Published online on: 10 March 2014

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Article

miR-101 suppresses the epithelial-to-mesenchymal transition by targeting ZEB1 and ZEB2 in ovarian carcinoma

Fei Guo, David Cogdell, Limei Hu, Da Yang, Anil K. Sood, Fengxia Xue, Wei Zhang
Pages: 2021-2028
Published online on: 21 March 2014

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Article

MicroRNA expression profiles in supraglottic carcinoma

Tianhong Zhang, Guojun Han, Yansong Wang, Kewa Chen, Yanan Sun
Pages: 2029-2034
Published online on: 27 March 2014

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Article

Overexpression of microRNA-143 inhibits growth and induces apoptosis in human leukemia cells

Jian-Zhen Shen, Yuan-Yuan Zhang, Hai-Ying Fu, Dan-Sen Wu, Hua-Rong Zhou
Pages: 2035-2042
Published online on: 11 March 2014

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Article

Low expression of GABARAPL1 is associated with a poor outcome for patients with hepatocellular carcinoma

Chao Liu, Yan Xia, Wei Jiang, Yinkun Liu, Long Yu
Pages: 2043-2048
Published online on: 19 March 2014

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Article

Eotaxin-1 promotes prostate cancer cell invasion via activation of the CCR3-ERK pathway and upregulation of MMP-3 expression

Feng Zhu, Pei Liu, Jun Li, Yan Zhang
Pages: 2049-2054
Published online on: 05 March 2014

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Article

MicroRNA-100 regulates SW620 colorectal cancer cell proliferation and invasion by targeting RAP1B

Hui Peng, Jun Luo, Hu Hao, Jun Hu, Shang-Kui Xie, Donglin Ren, Benqiang Rao
Pages: 2055-2062
Published online on: 11 March 2014

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Article

Thymoquinone induces G2/M arrest, inactivates PI3K/Akt and nuclear factor-κB pathways in human cholangiocarcinomas both in vitro and in vivo

Dongsheng Xu, Yong Ma, Baolei Zhao, Shuai Li, Yu Zhang, Shangha Pan, Yaohua Wu, Jizhou Wang, Dawei Wang, Huayang Pan, Lianxin Liu, Hongchi Jiang
Pages: 2063-2070
Published online on: 05 March 2014

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Article

MCM7 serves as a prognostic marker in diffuse-type gastric adenocarcinoma and siRNA-mediated knockdown suppresses its oncogenic function

Wei Kang, Joanna H.M. Tong, Anthony W.H. Chan, Alfred S.L. Cheng, Jun Yu, Kafai To
Pages: 2071-2078
Published online on: 19 March 2014

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Article

Editing genomic DNA in cancer cells with high genetic variance: Benefit or risk?

Lin Wang, Yixiang Wang, Chuanbin Guo
Pages: 2079-2084
Published online on: 06 March 2014

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Article

Suppressive role of miR-502-5p in breast cancer via downregulation of TRAF2

Li-Li Sun, Jian Wang, Zhi-Juan Zhao, Ning Liu, Ai-Lian Wang, Hua-Yan Ren, Fan Yang, Ke-Xin Diao, Wei-Neng Fu, En-Hua Wan, Xiao-Yi Mi
Pages: 2085-2092
Published online on: 21 March 2014

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Article

A targeting peptide improves adenovirus-mediated transduction of a glioblastoma cell line

Dongyang Wang, Wenbo Li, Hang Zhang, Qinwen Mao, Haibin Xia
Pages: 2093-2098
Published online on: 06 March 2014

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Article

Prostaglandin E2 receptor EP2 mediates Snail expression in hepatocellular carcinoma cells

Shan-Yu Cheng, Hai Zhang, Min Zhang, Shu-Kai Xia, Xiao‑Ming Bai, Li Zhang, Juan Ma, Rong Rong, Yi-Pin Wang, Ming-Zhan Du, Jie Wang, Meng Chen, Feng Shi, Qin-Yi Yang, Jing Leng
Pages: 2099-2106
Published online on: 11 March 2014

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Article

Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer

Jiasheng Mu, Haineng Xu, Yu Yang, Weidan Huang, Jing Xiao, Maolan Li, Zhujun Tan, Qichen Ding, Lin Zhang, Jianhua Lu, Xiangsong Wu, Yingbin Liu
Pages: 2107-2114
Published online on: 06 March 2014

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Article

Cetuximab-mediated ADCC activity is correlated with the cell surface expression level of EGFR but not with the KRAS/BRAF mutational status in colorectal cancer

Yuki Seo, Yoshiyuki Ishii, Hiroki Ochiai, Kazumasa Fukuda, Shingo Akimoto, Tetsu Hayashida, Koji Okabayashi, Masashi Tsuruta, Hirotoshi Hasegawa, Yuko Kitagawa
Pages: 2115-2122
Published online on: 11 March 2014

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Article

IL-1β-stimulated urokinase plasminogen activator expression through NF-κB in gastric cancer after HGF treatment

Kyung Hee Lee, Eun Young Choi, Sung Ae Koh, Min Kyoung Kim, Byung Ik Jang, Sang Woon Kim, Jae-Ryong Kim
Pages: 2123-2130
Published online on: 12 March 2014

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Article

β-elemene reverses the drug resistance of lung cancer A549/DDP cells via the mitochondrial apoptosis pathway

Cheng-Cai Yao, Yuan-Rong Tu, Jie Jiang, Sheng-Fang Ye, Hao-Xin Du, Yi Zhang
Pages: 2131-2138
Published online on: 12 March 2014

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Article

Aberrant DNA methylation in the IFITM1 promoter enhances the metastatic phenotype in an intraperitoneal xenograft model of human ovarian cancer

Nam Hee Kim, Hye Youn Sung, Eun Nam Choi, Dahyun Lyu, Hyuck Jae Choi, Woong Ju, Jung-Hyuck Ahn
Pages: 2139-2146
Published online on: 24 March 2014

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Article

MicroRNA expression profiles in human breast cancer cells after multifraction and single-dose radiation treatment

Chung-Man Leung, Ting-Wen Chen, Sung-Chou Li, Meng-Ru Ho, Ling-Yueh Hu, Wen‑Shan Liu, Tony T. Wu, Ping-Chi Hsu, Hong-Tai Chang, Kuo-Wang Tsai
Pages: 2147-2156
Published online on: 13 March 2014

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Article

Coexpression of ANXA2, SOD2 and HOXA13 predicts poor prognosis of esophageal squamous cell carcinoma

Ruo-Lan Ma, Lu-Yan  Shen, Ke-Neng  Chen
Pages: 2157-2164
Published online on: 12 March 2014

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Article

Proteomic and functional analyses demonstrate the involvement of oxidative stress in the anticancer activities of oridonin in HepG2 cells

Hui Wang, Yan Ye, Zhi-Ling Yu
Pages: 2165-2172
Published online on: 12 March 2014

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Article

STAT3 inhibitor WP1066 attenuates miRNA-21 to suppress human oral squamous cell carcinoma growth in vitro and in vivo

Xuan Zhou, Yu Ren, Aiqin Liu, Lei Han, Kailiang Zhang, Shasha Li, Peng Li, Ping Li, Chunsheng Kang, Xudong Wang, Lun Zhang
Pages: 2173-2180
Published online on: 27 March 2014

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Article

Triptolide-induced in vitro and in vivo cytotoxicity in human breast cancer stem cells and primary breast cancer cells

Junjie Li, Ruilei Liu, Ye Yang, Yong Huang, Xi Li, Ruiming Liu, Xiaoyan Shen
Pages: 2181-2186
Published online on: 27 March 2014

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Article

Upregulation of the splice variant MUC4/Y in the pancreatic cancer cell line MIA PaCa-2 potentiates proliferation and suppresses apoptosis: New insight into the presence of the transcript variant of MUC4

Kunling Xie, Xiaofei Zhi, Jie Tang, Yi Zhu, Jingjing Zhang, Zheng Li, Jinqiu Tao, Zekuan Xu
Pages: 2187-2194
Published online on: 27 March 2014

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Article

Dosimetric comparison of left-sided whole breast irradiation with 3D-CRT, IP-IMRT and hybrid IMRT

Xiaoxue Xie, Shuyu Ouyang, Hui Wang, Wenjuan Yang, Hekun Jin, Bingqiang Hu, Liangfang Shen
Pages: 2195-2205
Published online on: 05 March 2014

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Article

Aberrant CpG island methylation of PTEN is an early event in nasopharyngeal carcinoma and a potential diagnostic biomarker

Jinbang Li, Pinggui Gong, Xiaoming Lyu, Kaitai Yao, Xin Li, Hong Peng
Pages: 2206-2212
Published online on: 05 March 2014

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Article

Ki-67 as an independent prognostic factor in an unselected cohort of patients with ovarian cancer: Results of an explorative, retrospective study

Marco Johannes Battista, Nina Mantai, Isabel Sicking, Cristina Cotarelo, Veronika Weyer, Antje Lebrecht, Christine Solbach, Marcus Schmidt
Pages: 2213-2219
Published online on: 11 March 2014

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Article

Synergistic effect of nanosecond pulsed electric field combined with low-dose of pingyangmycin on salivary adenoid cystic carcinoma

Wei Qi, Jinsong Guo, Shan Wu, Bo Su, Lei Zhang, Jie Pan, Jue Zhang
Pages: 2220-2228
Published online on: 06 March 2014

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Article

Evaluation of premature senescence and senescence biomarkers in carcinoma cells and xenograft mice exposed to single or fractionated irradiation

Bong Cho Kim, Hee Jung Yoo, Hyung Chul Lee, Kyoung-Ah Kang, Seung Hee Jung, Hae-June Lee, Minyoung Lee, Seungwoo Park, Young-Hoon Ji, Yun-Sil Lee, Young-Gyu Ko, Jae-Seon Lee
Pages: 2229-2235
Published online on: 07 March 2014

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Article

PTEN mutation, loss of heterozygosity, promoter methylation and expression in colorectal carcinoma: Two hits on the gene?

Maja Hühns, Tareq Salem, Björn Schneider, Mathias Krohn, Michael Linnebacher, Friedrich Prall
Pages: 2236-2244
Published online on: 19 March 2014

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Article

L-securinine induces apoptosis in the human promyelocytic leukemia cell line HL-60 and influences the expression of genes involved in the PI3K/AKT/mTOR signaling pathway

Shuwen Han, Gang Zhang, Maidong Li, Dongyun Chen, Ying Wang, Wencai Ye, Zhaoning Ji
Pages: 2245-2251
Published online on: 20 March 2014

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Article

Antitumor effect of a selective COX-2 inhibitor, celecoxib, may be attributed to angiogenesis inhibition through modulating the PTEN/PI3K/Akt/HIF-1 pathway in an H22 murine hepatocarcinoma model

Wenwen Sui, Yueying Zhang, Zhaopeng Wang, Zhaoxia Wang, Qing Jia, Licun Wu, Weidong Zhang
Pages: 2252-2260
Published online on: 19 March 2014

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Article

MicroRNA-127-3p promotes glioblastoma cell migration and invasion by targeting the tumor-suppressor gene SEPT7

Huawei Jiang, Dasong Hua, Jing Zhang, Qing Lan, Qiang Huang, Jae-Geun Yoon, Xu Han, Lisha Li, Gregory Foltz, Shu Zheng, Biaoyang Lin
Pages: 2261-2269
Published online on: 05 March 2014

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Article

Tumor suppressor DLC-1 induces apoptosis and inhibits the growth and invasion of colon cancer cells through the Wnt/β-catenin signaling pathway

Chunyi Wang, Jialin Wang, Hong Liu, Zhongxue Fu
Pages: 2270-2278
Published online on: 05 March 2014

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Article

N-myc downstream regulated gene 1 acts as a tumor suppressor in ovarian cancer

Bei Wang, Jianli Li, Zhanying Ye, Zhe Li, Xiaohua Wu
Pages: 2279-2285
Published online on: 11 March 2014

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Article

Induction of apoptosis by diphenyldifluoroketone in osteogenic sarcoma cells is associated with activation of caspases

Seok-Jin Yang, Seul Ah Lee, Min-Gyeong Park, Jae-Sung Kim, Sun-Kyoung Yu, Chun Sung Kim, Jin-Soo Kim, Su-Gwan Kim, Ji-Su Oh, Heung-Joong Kim, Hong Sung Chun, Yong Hwan Kim, Do Kyung Kim
Pages: 2286-2292
Published online on: 06 March 2014

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Article

Synergistic antitumor activity of resveratrol and miR-200c in human lung cancer

Tao Bai, Dao-Song Dong, Ling Pei
Pages: 2293-2297
Published online on: 14 March 2014

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Article

Functional expression of TLR9 in esophageal cancer

Yanli Zhang, Qiuyan Wang, Ailing Ma, Yunhong Li, Rui Li, Yin Wang
Pages: 2298-2304
Published online on: 19 March 2014

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Article

Arsenic hexoxide enhances TNF-α-induced anticancer effects by inhibiting NF-κB activity at a safe dose in MCF-7 human breast cancer cells

Min Jeong Kim, Ji Hyun Jung, Won Sup Lee, Jeong Won Yun, Jing Nan Lu, Sang Mi Yi, Hye Jung Kim, Seong-Hwan Chang, Gon-Sup Kim, Soon Chan Hong, Woo Song Ha
Pages: 2305-2311
Published online on: 12 March 2014

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Article

SPARC expression is negatively correlated with clinicopathological factors of gastric cancer and inhibits malignancy of gastric cancer cells

Junling Zhang, Pengyuan Wang, Jing Zhu, Wei Wang, Jie Yin, Chi Zhang, Ziyi Chen, Lie Sun, Yuanlian Wan, Xin Wang, Guowei Chen, Yucun Liu
Pages: 2312-2320
Published online on: 27 March 2014

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Article

Autophagy promotes the survival and development of tumors by participating in the formation of vasculogenic mimicry

Yun-Peng Ding, Xiao-Dong Yang, Yong Wu, Chun-Gen Xing
Pages: 2321-2327
Published online on: 12 March 2014

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Article

Vigilin is overexpressed in hepatocellular carcinoma and is required for HCC cell proliferation and tumor growth

Wen Li Yang, Ling Wei, Wen Qing Huang, Ran Li, Wen Yan Shen, Jian Yu Liu, Jian Ming Xu, Bo Li, Yang Qin
Pages: 2328-2334
Published online on: 24 March 2014

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Article

Synergistic effect of arginine-specific ADP-ribosyltransferase 1 and poly(ADP-ribose) polymerase-1 on apoptosis induced by cisplatin in CT26 cells

Jing Kuang, Ya-Lan Wang, Ming Xiao, Yi Tang, Wen‑Wen Chen, Guang-Lin Song, Xi Yang, Ming Li
Pages: 2335-2343
Published online on: 20 March 2014

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Article

Knockdown of S100P by lentiviral-mediated RNAi promotes apoptosis and suppresses the colony-formation ability of gastric cancer cells

Qi Zhang, Haolin Hu, Xin Shi, Wenhao Tang
Pages: 2344-2350
Published online on: 21 March 2014

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Article

FRZB knockdown upregulates β-catenin activity and enhances cell aggressiveness in gastric cancer

Shuai Qin, Zhuo Zhang, Jianfang Li, Lu Zang
Pages: 2351-2357
Published online on: 24 March 2014

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Article

Breast cancer cells are arrested at different phases of the cell cycle following the re-expression of ARHI Retraction in /10.3892/or.2025.8916

Xiaoxiao Zuo, Yan Qin, Xiaojin Zhang, Qian Ning, Shan Shao, Minna Luo, Na Yuan, Shangke Huang, Xinhan Zhao
Pages: 2358-2364
Published online on: 21 March 2014

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Article

The role of autophagy induced by pemetrexed in lung adenocarcinoma cells

Ji-Hye Park, Young-Rae Lee, Hong-Seob So, Kang-Kyoo Lee, Sam‑Youn Lee, Sun-Rock Moon, Hyang-Jeong Jo, Seoul Lee, Kyuyong Jeong, Kang-Beom Kwon, Sei-Hoon Yang
Pages: 2365-2370
Published online on: 10 March 2014

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Article

Vitamin B6 activates p53 and elevates p21 gene expression in cancer cells and the mouse colon

Peipei Zhang, Sofya Suidasari, Tomomi Hasegawa, Noriyuki Yanaka, Norihisa Kato
Pages: 2371-2376
Published online on: 11 March 2014

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Article

Isoquercitrin inhibits the progression of liver cancer in vivo and in vitro via the MAPK signalling pathway Retraction in /10.3892/or.2023.8510

Guihong Huang, Bo Tang, Kun Tang, Xiaomin Dong, Jungang Deng, Luqin Liao, Zengzhen Liao, Hua Yang, Songqing He
Pages: 2377-2384
Published online on: 20 March 2014

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Article

Expression of the monocyte chemotactic protein-1-induced protein 1 decreases human neuroblastoma cell survival

Anna Skalniak, Elżbieta Boratyn, Sylwia D. Tyrkalska, Irena Horwacik, Małgorzata Durbas, Maria Łastowska, Jolanta Jura, Hanna Rokita
Pages: 2385-2392
Published online on: 11 March 2014

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Article

Transphosphorylation of EGFR at Y845 plays an important role in its autophosphorylation and kinase activity

Hui Song, Lei Huang, Ming Zhang, Xiuwei Wang, Shuang Song, Lin Yang
Pages: 2393-2398
Published online on: 21 March 2014

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Article

Oleanolic acid enhances the radiosensitivity of tumor cells under mimetic hypoxia through the reduction in intracellular GSH content and HIF-1α expression

Rongxin Qi, Wenwen Jin, Juan Wang, Qiyi Yi, Maohu Yu, Shiguo Xu, Wensen Jin
Pages: 2399-2406
Published online on: 06 March 2014

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Article

Assessment of tumor size as a useful marker for the surgical staging of endometrial cancer

Roberto Berretta, Tito Silvio Patrelli, Costanza Migliavacca, Martino Rolla, Laura Franchi, Michela Monica, Alberto Bacchi Modena, Salvatore Gizzo
Pages: 2407-2412
Published online on: 21 March 2014

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Anti-apoptotic effect of caspase inhibitors on H2O2-treated HeLa cells through early suppression of its oxidative stress

Woo Hyun Park
Pages: 2413-2421
Published online on: 12 March 2014

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Article

Arecoline inhibits epithelial cell viability by upregulating the apoptosis pathway: Implication for oral submucous fibrosis

Ming Li, Feng Gao, Zhong-Su Zhou, Hui-Ming Zhang, Rui Zhang, Ying-Fang Wu, Ming-Hai Bai, Ji-Jia Li, Shi-Rong Lin, Jie-Ying Peng
Pages: 2422-2428
Published online on: 14 March 2014

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Sequential treatment of HPV E6 and E7-expressing TC-1 cells with bortezomib and celecoxib promotes apoptosis through p-p38 MAPK-mediated downregulation of cyclin D1 and CDK2

Jee-Eun Kim, Ji-In Lee, Dong-Hoon Jin, Wang Jae Lee, Ga Bin Park, Seonghan Kim, Yeong Seok Kim, T.-C. Wu, Dae Young Hur, Daejin Kim
Pages: 2429-2437
Published online on: 12 March 2014

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Article

Methylation and decreased expression of SHP-1 are related to disease progression in chronic myelogenous leukemia

Yinghua Li, Lin Yang, Yuxia Pan, Jingci Yang, Yintao Shang, Jianmin Luo
Pages: 2438-2446
Published online on: 19 March 2014

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Article

Polysaccharide from Inonotus obliquus inhibits migration and invasion in B16-F10 cells by suppressing MMP‑2 and MMP‑9 via downregulation of NF-κB signaling pathway

Ki Rim Lee, Jong Seok Lee, Young Rae Kim, In Gyu Song, Eock Kee Hong
Pages: 2447-2453
Published online on: 21 March 2014

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Article

LAPTM4B polymorphism is associated with non‑small cell lung cancer susceptibility and prognosis

Han Tang, Hui Tian, Weiming Yue, Lin Li, Shuhai Li, Cun Gao, Libo Si, Lei Qi, Ming Lu, Wensi Hu
Pages: 2454-2460
Published online on: 27 March 2014

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Journal Cover
January-2026 Volume 55 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Article Open Access

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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Article Open Access

S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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Review Open Access

The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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Review Open Access

From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Review Open Access

Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Article Open Access

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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