LIM homeobox transcription factors, a novel subfamily which plays an important role in cancer (Review)

  • Authors:
    • Xi Wang
    • Chao He
    • Xiaotong Hu
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  • Published online on: March 27, 2014     https://doi.org/10.3892/or.2014.3112
  • Pages: 1975-1985
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Abstract

LIM homeobox genes are one of the most important subfamilies of homeobox genes which encode LIM-homeodomain (LIM-HD) proteins featuring two LIM domains in their amino termini and a centrally located HD that is used to interact with specific DNA elements in target genes. Numerous studies have reported their fundamental roles in the development of various organisms; however, little is known about their functions in cancer. Recently, research has shown that LIM homeobox genes also play an important role in cancer development. Among 12 human LIM homeobox genes, 10 LIM-HD proteins have been reported to be associated with cancer. In the present review, we mainly summarize the functions of these genes in various types of cancer and their potential as biomarkers and the related challenges. More in-depth research concerning LIM homeobox genes in cancer from a signaling pathway perspective may help to understand tumor profiles, establish biomarkers and guide choices for combinatorial drug therapies.
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May-2014
Volume 31 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Wang X, He C and Hu X: LIM homeobox transcription factors, a novel subfamily which plays an important role in cancer (Review). Oncol Rep 31: 1975-1985, 2014
APA
Wang, X., He, C., & Hu, X. (2014). LIM homeobox transcription factors, a novel subfamily which plays an important role in cancer (Review). Oncology Reports, 31, 1975-1985. https://doi.org/10.3892/or.2014.3112
MLA
Wang, X., He, C., Hu, X."LIM homeobox transcription factors, a novel subfamily which plays an important role in cancer (Review)". Oncology Reports 31.5 (2014): 1975-1985.
Chicago
Wang, X., He, C., Hu, X."LIM homeobox transcription factors, a novel subfamily which plays an important role in cancer (Review)". Oncology Reports 31, no. 5 (2014): 1975-1985. https://doi.org/10.3892/or.2014.3112