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Article

MicroRNA expression profiles in supraglottic carcinoma

  • Authors:
    • Tianhong Zhang
    • Guojun Han
    • Yansong Wang
    • Kewa Chen
    • Yanan Sun
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Department of Anesthesiology, The First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China
  • Pages: 2029-2034
    |
    Published online on: March 27, 2014
       https://doi.org/10.3892/or.2014.3117
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Abstract

MicroRNAs (miRNAs) are single-stranded RNA molecules which regulate gene expression at the post-transcriptional level and several miRNAs have been found to be associated with some types of cancer. We sought to identify the expression and involvement of miRNAs in supraglottic carcinoma tissues compared with normal tissues and to determine whether miRNA expression is predictive of disease. Unsupervised clustering shows that miRNA profiles can distinguish tumor from normal tissues. Analysis of miRNA contents in supraglottic carcinoma highlighted nineteen differentially expressed miRNAs, three upregulated miRNAs (miR-21, miR-19a, miR-33a) and two downregulated miRNAs (miR-206, miR-375). The microarray results of supraglottic carcinoma and related computer analysis may be beneficial for further analysis of cancer diagnosis and therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang T, Han G, Wang Y, Chen K and Sun Y: MicroRNA expression profiles in supraglottic carcinoma. Oncol Rep 31: 2029-2034, 2014.
APA
Zhang, T., Han, G., Wang, Y., Chen, K., & Sun, Y. (2014). MicroRNA expression profiles in supraglottic carcinoma. Oncology Reports, 31, 2029-2034. https://doi.org/10.3892/or.2014.3117
MLA
Zhang, T., Han, G., Wang, Y., Chen, K., Sun, Y."MicroRNA expression profiles in supraglottic carcinoma". Oncology Reports 31.5 (2014): 2029-2034.
Chicago
Zhang, T., Han, G., Wang, Y., Chen, K., Sun, Y."MicroRNA expression profiles in supraglottic carcinoma". Oncology Reports 31, no. 5 (2014): 2029-2034. https://doi.org/10.3892/or.2014.3117
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang T, Han G, Wang Y, Chen K and Sun Y: MicroRNA expression profiles in supraglottic carcinoma. Oncol Rep 31: 2029-2034, 2014.
APA
Zhang, T., Han, G., Wang, Y., Chen, K., & Sun, Y. (2014). MicroRNA expression profiles in supraglottic carcinoma. Oncology Reports, 31, 2029-2034. https://doi.org/10.3892/or.2014.3117
MLA
Zhang, T., Han, G., Wang, Y., Chen, K., Sun, Y."MicroRNA expression profiles in supraglottic carcinoma". Oncology Reports 31.5 (2014): 2029-2034.
Chicago
Zhang, T., Han, G., Wang, Y., Chen, K., Sun, Y."MicroRNA expression profiles in supraglottic carcinoma". Oncology Reports 31, no. 5 (2014): 2029-2034. https://doi.org/10.3892/or.2014.3117
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