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Article

Expression and significance of the novel tumor-suppressor gene SMG-1 in hepatocellular carcinoma

  • Authors:
    • Li-Li Han
    • Hao-Cheng Nan
    • Tao Tian
    • Hui Guo
    • Ting-Hua Hu
    • Wen-Juan Wang
    • Jie-Qun Ma
    • Li-Li Jiang
    • Qian-Qian Guo
    • Cheng-Cheng Yang
    • Xiao-Min Kang
    • Ying Liu
    • Yuan Gao
    • Qi-Lun Liu
    • Ke-Jun Nan
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, First Affiliated Hospital, College of Medicine of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Surgical Oncology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China
  • Pages: 2569-2578
    |
    Published online on: April 2, 2014
       https://doi.org/10.3892/or.2014.3125
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Abstract

Recent studies have demonstrated that SMG-1, a newly characterized member of the family of phosphatidylinositol 3-kinase-related protein kinases (PIKKs), is involved in tumorigenesis as a new tumor suppressor. However, its expression and significance in hepatocellular carcinoma (HCC) remain obscure. The present study investigated SMG-1 expression in HCC tissue specimens, aimed at defining the association with clinicopathological significance. Both immunohistochemistry and qRT-PCR were employed to analyze SMG-1 expression in 157 HCC and corresponding distant normal tissue specimens. The results revealed that expression of SMG-1 was significantly lower in the HCC tissue specimens than that in the distant normal tissues. Moreover, a lower expression level of SMG-1 was significantly correlated with serum α-fetoprotein level (P=0.001), poorly differentiated tumors (P=0.009) and more advanced TNM stage (P<0.001). Further study showed that SMG-1 expression was exactly associated with tumor differentiation and clinical stage in HCC. Kaplan-Meier analysis indicated that low SMG-1 expression was related to poor overall survival, and the prognostic impact of SMG-1 was further confirmed by stratified survival analysis. Importantly, multivariate analysis revealed that low SMG-1 expression was an independent prognostic marker for an unfavorable overall survival. We conclude that SMG-1 is downregulated in HCC and may represent a promising biomarker for predicting the prognosis of HCC, including the prognosis of early-stage patients.
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Copy and paste a formatted citation
Spandidos Publications style
Han L, Nan H, Tian T, Guo H, Hu T, Wang W, Ma J, Jiang L, Guo Q, Yang C, Yang C, et al: Expression and significance of the novel tumor-suppressor gene SMG-1 in hepatocellular carcinoma. Oncol Rep 31: 2569-2578, 2014.
APA
Han, L., Nan, H., Tian, T., Guo, H., Hu, T., Wang, W. ... Nan, K. (2014). Expression and significance of the novel tumor-suppressor gene SMG-1 in hepatocellular carcinoma. Oncology Reports, 31, 2569-2578. https://doi.org/10.3892/or.2014.3125
MLA
Han, L., Nan, H., Tian, T., Guo, H., Hu, T., Wang, W., Ma, J., Jiang, L., Guo, Q., Yang, C., Kang, X., Liu, Y., Gao, Y., Liu, Q., Nan, K."Expression and significance of the novel tumor-suppressor gene SMG-1 in hepatocellular carcinoma". Oncology Reports 31.6 (2014): 2569-2578.
Chicago
Han, L., Nan, H., Tian, T., Guo, H., Hu, T., Wang, W., Ma, J., Jiang, L., Guo, Q., Yang, C., Kang, X., Liu, Y., Gao, Y., Liu, Q., Nan, K."Expression and significance of the novel tumor-suppressor gene SMG-1 in hepatocellular carcinoma". Oncology Reports 31, no. 6 (2014): 2569-2578. https://doi.org/10.3892/or.2014.3125
Copy and paste a formatted citation
x
Spandidos Publications style
Han L, Nan H, Tian T, Guo H, Hu T, Wang W, Ma J, Jiang L, Guo Q, Yang C, Yang C, et al: Expression and significance of the novel tumor-suppressor gene SMG-1 in hepatocellular carcinoma. Oncol Rep 31: 2569-2578, 2014.
APA
Han, L., Nan, H., Tian, T., Guo, H., Hu, T., Wang, W. ... Nan, K. (2014). Expression and significance of the novel tumor-suppressor gene SMG-1 in hepatocellular carcinoma. Oncology Reports, 31, 2569-2578. https://doi.org/10.3892/or.2014.3125
MLA
Han, L., Nan, H., Tian, T., Guo, H., Hu, T., Wang, W., Ma, J., Jiang, L., Guo, Q., Yang, C., Kang, X., Liu, Y., Gao, Y., Liu, Q., Nan, K."Expression and significance of the novel tumor-suppressor gene SMG-1 in hepatocellular carcinoma". Oncology Reports 31.6 (2014): 2569-2578.
Chicago
Han, L., Nan, H., Tian, T., Guo, H., Hu, T., Wang, W., Ma, J., Jiang, L., Guo, Q., Yang, C., Kang, X., Liu, Y., Gao, Y., Liu, Q., Nan, K."Expression and significance of the novel tumor-suppressor gene SMG-1 in hepatocellular carcinoma". Oncology Reports 31, no. 6 (2014): 2569-2578. https://doi.org/10.3892/or.2014.3125
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