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Article

Overexpression of ZDHHC14 promotes migration and invasion of scirrhous type gastric cancer

  • Authors:
    • Htoo Zarni Oo
    • Kazuhiro Sentani
    • Naoya Sakamoto
    • Katsuhiro Anami
    • Yutaka Naito
    • Naohiro Uraoka
    • Takashi Oshima
    • Kazuyoshi Yanagihara
    • Naohide Oue
    • Wataru Yasui
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima 734-8551, Japan, Gastroenterological Center, Yokohama City University Medical Center, Yokohama 232-0024, Japan, Division of Translational Research, Exploratory Oncology and Clinical Trial Center, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, Japan
  • Pages: 403-410
    |
    Published online on: May 6, 2014
       https://doi.org/10.3892/or.2014.3166
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Abstract

Scirrhous type gastric cancer is highly aggressive and has a poorer prognosis than many other types of gastric carcinoma, due to its characteristic rapid cancer cell infiltration and proliferation, extensive stromal fibrosis, and frequent peritoneal dissemination. The aim of the present study was to identify novel prognostic markers or therapeutic targets for scirrhous type gastric cancer. We reviewed a list of genes with upregulated expression in scirrhous type gastric cancer and compared their expression with that in normal stomach from our previous Escherichia coli (E. coli) ampicillin secretion-trap (CAST) analysis. We focused on the ZDHHC14 gene, which encodes zinc finger, DHHC-type containing 14 protein. qRT-PCR analysis of ZDHHC14 in 41 gastric cancer cases revealed that compared to mRNA levels in normal non-neoplastic gastric mucosa, ZDHHC14 mRNA was overexpressed in 27% of gastric cancer tissue samples. The overexpression of ZDHHC14 was significantly associated with depth of tumor invasion, undifferentiated histology and scirrhous pattern. The invasiveness of ZDHHC14-knockdown HSC-44PE and 44As3 gastric cancer cells was decreased in comparison with that of the negative control siRNA-transfected cells, together with downregulation of MMP-17 mRNA. Integrins α5 and β1 were also downregulated in ZDHHC14-knockdown 44As3 cells. Forced expression of ZDHHC14 activated gastric cancer cell migration and invasion in vitro. These results indicate that ZDHHC14 is involved in tumor progression in patients with scirrhous type gastric cancer.
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1 

Yasui W: Future perspectives of gastric cancer treatment: from bench to bedside. Pathobiology. 78:293–294. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma: 3rd English edition. Gastric Cancer. 14:101–112. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Yanagihara K, Takigahira M, Tanaka H, Komatsu T, Fukumoto H, Koizumi F, Nishio K, Ochiya T, Ino Y and Hirohashi S: Development and biological analysis of peritoneal metastasis mouse models for human scirrhous stomach cancer. Cancer Sci. 96:323–332. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Hippo Y, Yashiro M, Ishii M, Taniguchi H, Tsutsumi S, Hirakawa K, Kodama T and Aburatani H: Differential gene expression profiles of scirrhous gastric cancer cells with high metastatic potential to peritoneum or lymph nodes. Cancer Res. 61:889–895. 2001.PubMed/NCBI

5 

Jass JR, Sobin LH and Watanabe H: The World Health Organization’s histologic classification of gastrointestinal tumors. A commentary on the second edition. Cancer. 66:2162–2167. 1990.

6 

Lockhart DJ, Dong H, Byrne MC, Follettie MT, Gallo MV, Chee MS, Mittmann M, Wang C, Kobayashi M, Horton H and Brown EL: Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat Biotechnol. 14:1675–1680. 1996. View Article : Google Scholar : PubMed/NCBI

7 

Velculescu VE, Zhang L, Vogelstein B and Kinzler KW: Serial analysis of gene expression. Science. 270:484–487. 1995. View Article : Google Scholar : PubMed/NCBI

8 

Oue N, Hamai Y, Mitani Y, Matsumura S, Oshimo Y, Aung PP, Kuraoka K, Nakayama H and Yasui W: Gene expression profile of gastric carcinoma: identification of genes and tags potentially involved in invasion, metastasis, and carcinogenesis by serial analysis of gene expression. Cancer Res. 64:2397–2405. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Mitani Y, Oue N, Matsumura S, Yoshida K, Noguchi T, Ito M, Tanaka S, Kuniyasu H, Kamata N and Yasui W: Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy. Oncogene. 26:4383–4393. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Oue N, Sentani K, Noguchi T, Ohara S, Sakamoto N, Hayashi T, Anami K, Motoshita J, Ito M, Tanaka S, Yoshida K and Yasui W: Serum olfactomedin 4 (GW112, hGC-1) in combination with Reg IV is a highly sensitive biomarker for gastric cancer patients. Int J Cancer. 125:2383–2392. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Sentani K, Oue N, Sakamoto N, Arihiro K, Aoyagi K, Sasaki H and Yasui W: Gene expression profiling with microarray and SAGE identifies PLUNC as a marker for hepatoid adenocarcinoma of the stomach. Mod Pathol. 21:464–475. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Sentani K, Oue N, Sakamoto N, Anami K, Naito Y, Aoyagi K, Sasaki H and Yasui W: Upregulation of connexin 30 in intestinal phenotype gastric cancer and its reduction during tumor progression. Pathobiology. 77:241–248. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Yu L, Reader JC, Chen C, Zhao XF, Ha JS, Lee C, York T, Gojo I, Baer MR and Ning Y: Activation of a novel palmitoyltransferase ZDHHC14 in acute biphenotypic leukemia and subsets of acute myeloid leukemia. Leukemia. 25:367–371. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Kondo T, Oue N, Yoshida K, Mitani Y, Naka K, Nakayama H and Yasui W: Expression of POT1 is associated with tumor stage and telomere length in gastric carcinoma. Cancer Res. 64:523–529. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Yasui W, Ayhan A, Kitadai Y, Nishimura K, Yokozaki H, Ito H and Tahara E: Increased expression of p34cdc2 and its kinase activity in human gastric and colonic carcinomas. Int J Cancer. 53:36–41. 1993. View Article : Google Scholar : PubMed/NCBI

16 

Ochiai A, Yasui W and Tahara E: Growth-promoting effect of gastrin on human gastric carcinoma cell line TMK-1. Jpn J Cancer Res. 76:1064–1071. 1985.PubMed/NCBI

17 

Yanagihara K, Tanaka H, Takigahira M, Ino Y, Yamaguchi Y, Toge T, Sugano K and Hirohashi S: Establishment of two cell lines from human gastric scirrhous carcinoma that possess the potential to metastasize spontaneously in nude mice. Cancer Sci. 95:575–582. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Alley MC, Scudiero DA, Monks A, Hursey ML, Czerwinski MJ, Fine DL, Abbott BJ, Mayo JG, Shoemaker RH and Boyd MR: Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res. 48:589–601. 1988.PubMed/NCBI

19 

Sentani K, Oue N, Naito Y, Sakamoto N, Anami K, Oo HZ, Uraoka N, Aoyagi K, Sasaki H and Yasui W: Upregulation of HOXA10 in gastric cancer with the intestinal mucin phenotype: reduction during tumor progression and favorable prognosis. Carcinogenesis. 33:1081–1088. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Ohno Y, Kihara A, Sano T and Igarashi Y: Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Biochim Biophys Acta. 1761:474–483. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Linder ME and Deschenes RJ: Model organisms lead the way to protein palmitoyltransferases. J Cell Sci. 117:521–526. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Mitchell DA, Vasudevan A, Linder ME and Deschenes RJ: Protein palmitoylation by a family of DHHC protein S-acyltransferases. J Lipid Res. 47:1118–1127. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Matakatsu H and Blair SS: The DHHC palmitoyltransferase approximated regulates Fat signaling and Dachs localization and activity. Curr Biol. 18:1390–1395. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Dunphy JT and Linder ME: Signalling functions of protein palmitoylation. Biochim Biophys Acta. 1436:245–261. 1998. View Article : Google Scholar : PubMed/NCBI

25 

Resh MD: Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins. Biochim Biophys Acta. 1451:1–16. 1999. View Article : Google Scholar : PubMed/NCBI

26 

Hynes RO: Integrins: Versatility, modulation, and signaling in cell adhesion. Cell. 69:11–25. 1992. View Article : Google Scholar : PubMed/NCBI

27 

Moissoglu K and Schwartz MA: Integrin signalling in directed cell migration. Biol Cell. 98:547–555. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Yang X, Kovalenko OV, Tang W, Claas C, Stipp CS and Hemler ME: Palmitoylation supports assembly and function of integrin-tetraspanin complexes. J Cell Biol. 167:1231–1240. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Guo W and Giancotti FG: Integrin signalling during tumour progression. Nat Rev Mol Cell Biol. 5:816–826. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Dormond O and Rüegg C: Regulation of endothelial cell integrin function and angiogenesis by COX-2, cAMP and Protein Kinase A. Thromb Haemost. 90:577–585. 2003.PubMed/NCBI

31 

Sohail A, Sun Q, Zhao H, Bernardo MM, Cho JA and Fridman R: MT4-(MMP17) and MT6-MMP (MMP25), a unique set of membrane-anchored matrix metalloproteinases: properties and expression in cancer. Cancer Metastasis Rev. 27:289–302. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Oo HZ, Sentani K, Sakamoto N, Anami K, Naito Y, Uraoka N, Oshima T, Yanagihara K, Oue N, Yasui W, Yasui W, et al: Overexpression of ZDHHC14 promotes migration and invasion of scirrhous type gastric cancer. Oncol Rep 32: 403-410, 2014.
APA
Oo, H.Z., Sentani, K., Sakamoto, N., Anami, K., Naito, Y., Uraoka, N. ... Yasui, W. (2014). Overexpression of ZDHHC14 promotes migration and invasion of scirrhous type gastric cancer. Oncology Reports, 32, 403-410. https://doi.org/10.3892/or.2014.3166
MLA
Oo, H. Z., Sentani, K., Sakamoto, N., Anami, K., Naito, Y., Uraoka, N., Oshima, T., Yanagihara, K., Oue, N., Yasui, W."Overexpression of ZDHHC14 promotes migration and invasion of scirrhous type gastric cancer". Oncology Reports 32.1 (2014): 403-410.
Chicago
Oo, H. Z., Sentani, K., Sakamoto, N., Anami, K., Naito, Y., Uraoka, N., Oshima, T., Yanagihara, K., Oue, N., Yasui, W."Overexpression of ZDHHC14 promotes migration and invasion of scirrhous type gastric cancer". Oncology Reports 32, no. 1 (2014): 403-410. https://doi.org/10.3892/or.2014.3166
Copy and paste a formatted citation
x
Spandidos Publications style
Oo HZ, Sentani K, Sakamoto N, Anami K, Naito Y, Uraoka N, Oshima T, Yanagihara K, Oue N, Yasui W, Yasui W, et al: Overexpression of ZDHHC14 promotes migration and invasion of scirrhous type gastric cancer. Oncol Rep 32: 403-410, 2014.
APA
Oo, H.Z., Sentani, K., Sakamoto, N., Anami, K., Naito, Y., Uraoka, N. ... Yasui, W. (2014). Overexpression of ZDHHC14 promotes migration and invasion of scirrhous type gastric cancer. Oncology Reports, 32, 403-410. https://doi.org/10.3892/or.2014.3166
MLA
Oo, H. Z., Sentani, K., Sakamoto, N., Anami, K., Naito, Y., Uraoka, N., Oshima, T., Yanagihara, K., Oue, N., Yasui, W."Overexpression of ZDHHC14 promotes migration and invasion of scirrhous type gastric cancer". Oncology Reports 32.1 (2014): 403-410.
Chicago
Oo, H. Z., Sentani, K., Sakamoto, N., Anami, K., Naito, Y., Uraoka, N., Oshima, T., Yanagihara, K., Oue, N., Yasui, W."Overexpression of ZDHHC14 promotes migration and invasion of scirrhous type gastric cancer". Oncology Reports 32, no. 1 (2014): 403-410. https://doi.org/10.3892/or.2014.3166
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