Open Access

Galectin fingerprinting in naso-sinusal diseases

  • Authors:
    • Anaëlle Duray
    • Thibault De Maesschalck
    • Christine Decaestecker
    • Myriam Remmelink
    • Gilbert Chantrain
    • Jennifer Neiveyans
    • Mihaela Horoi
    • Xavier Leroy
    • Hans-Joachim Gabius
    • Sven Saussez
  • View Affiliations

  • Published online on: May 23, 2014     https://doi.org/10.3892/or.2014.3213
  • Pages: 23-32
  • Copyright: © Duray et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Galectins, a family of endogenous lectins, are multifunctional effectors that act at various sites and can be used in immunohistochemical localization studies of diseased states. Since they form a potentially cooperative and antagonistic network, we tested the hypothesis that histopathological fingerprinting of galectins could refine the molecular understanding of naso-sinusal pathologies. Using non-cross-reactive antibodies against galectin-1, -3, -4, -7, -8 and -9, we characterized the galectin profiles in chronic rhinosinusitis, nasal polyposis, inverted papillomas and squamous cell carcinomas. The expression, signal location and quantitative parameters describing the percentage of positive cells and labeling intensity were assessed for various cases. We discovered that inverted papillomas showed a distinct galectin immunohistochemical profile. Indeed, epithelial overexpression of galectin-3 (p=0.0002), galectin-4 (p<10-6), galectin-7 (p<10-6) and galectin-9 (p<10-6) was observed in inverted papillomas compared to non-malignant diseases. Regarding carcinomas, we observed increased expression of galectin-9 (p<10-6) in epithelial cells compared to non-tumor pathologies. Our results suggest that galectin-3, -4, -7 and -9 could be involved in the biology of inverted papillomas. In addition, we observed that the expression of galectin in naso-sinusal diseases seems to be affected by tumor progression and not inflammatory or allergic phenomena.
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July-2014
Volume 32 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Duray A, De Maesschalck T, Decaestecker C, Remmelink M, Chantrain G, Neiveyans J, Horoi M, Leroy X, Gabius H, Saussez S, Saussez S, et al: Galectin fingerprinting in naso-sinusal diseases. Oncol Rep 32: 23-32, 2014
APA
Duray, A., De Maesschalck, T., Decaestecker, C., Remmelink, M., Chantrain, G., Neiveyans, J. ... Saussez, S. (2014). Galectin fingerprinting in naso-sinusal diseases. Oncology Reports, 32, 23-32. https://doi.org/10.3892/or.2014.3213
MLA
Duray, A., De Maesschalck, T., Decaestecker, C., Remmelink, M., Chantrain, G., Neiveyans, J., Horoi, M., Leroy, X., Gabius, H., Saussez, S."Galectin fingerprinting in naso-sinusal diseases". Oncology Reports 32.1 (2014): 23-32.
Chicago
Duray, A., De Maesschalck, T., Decaestecker, C., Remmelink, M., Chantrain, G., Neiveyans, J., Horoi, M., Leroy, X., Gabius, H., Saussez, S."Galectin fingerprinting in naso-sinusal diseases". Oncology Reports 32, no. 1 (2014): 23-32. https://doi.org/10.3892/or.2014.3213