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Article

Asparagine synthetase expression and its potential prognostic value in patients with NK/T cell lymphoma

  • Authors:
    • Yaqing Li
    • Xudong Zhang
    • Tengpeng Hu
    • Lijuan Han
    • Ruping Li
    • Jianguo Wen
    • Mingzhi Zhang
  • View Affiliations / Copyright

    Affiliations: Lymphoma Diagnosis and Treatment Center, Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, The Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
  • Pages: 853-859
    |
    Published online on: June 6, 2014
       https://doi.org/10.3892/or.2014.3237
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Abstract

Natural killer (NK)/T cell lymphoma usually shows a highly aggressive clinical course and the overall prognosis is poor. At present, there are no standard therapeutic regimens for this disease. Although chemotherapeutic protocols containing L-asparaginase (L-Asp) or pegaspargase (PEG‑Asp) have improved the efficacy of treatment, some patients are resistant to L-Asp or PEG-Asp. Previous studies demonstrated that the elevated expression of asparagine synthetase (ASNS) is correlated with the resistance to L-Asp or PEG-Asp and may also affect the prognosis in some types of tumors, but the expression level and clinical significance of ASNS in NK/T cell lymphoma remain unknown. Therefore, we investigated the expression and clinical significance of ASNS in lymphoma cell lines and patients with NK/T cell lymphoma. Firstly, we detected PEG-Asp and L-Asp activity using MTT assay and expression of ASNS using real-time PCR in the 7 lymphoma cell lines. Secondly, we used branched DNA-liquidchip technology (bDNA-LCT) for detecting ASNS mRNA in formalin-fixed, paraffin-embedded tissue sections in 50 cases of NK/T cell lymphoma and in 12 cases of nasal polyps and chronic rhinitis. Moreover, we analyzed the correlations between the expression of ASNS and the sensitivity to L-Asp and PEG-Asp in 7 lymphoma cell lines and with clinicopathological features and prognosis of NK/T cell lymphoma patients who used chemotherapy containing L-Asp and PEG-Asp. There was a marked difference in the sensitivity to L-Asp and PEG-Asp of the 7 lymphoma cell lines. YTS and SNK-6 cells were highly sensitive to PEG-Asp and had relatively low levels of ASNS mRNA expression. Hut-78, Jurkat and Karpas 299 cells were naturally resistant to PEG-Asp, and the ASNS expression levels were extremely high. The expression level of ASNS was relatively low in the NK/T cell lymphoma tissue compared to levels in the nasal polyps and chronic rhinitis (0.480±0.307 vs. 0.739±0.267; P=0.009). ASNS expression level was associated with III-IV tumor stage (P=0.041) and a high International Prognostic Index (P=0.018) in patients with NK/T cell lymphoma. The NK/T cell lymphoma patients with higher ASNS expression had a reduced median survival time when compared with the survival of patients with low ASNS expression (P=0.033). Cox regression test showed that the ASNS expression level is an independent prognostic factor for NK/T cell lymphoma patients. In conclusion, the expression of ASNS was closely related with the sensitivity of lymphoma cell lines to L-Asp and PEG-Asp in vitro and also had a certain effect on the survival of NK/T cell lymphoma patients. In conclusion, high ASNS expression in NK/T cell lymphoma is correlated with worse clinicopathological features.
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1 

Aozasa K, Ohsawa M, Tajima K, Sasaki R, Maeda H, Matsunaga T and Friedmann I: Nation-wide study of lethal mid-line granuloma in Japan: frequencies of wegener’s granulo matosis, polymorphic reticulosis, malignant lymphoma and other related conditions. Int J Cancer. 44:63–66. 1989.PubMed/NCBI

2 

Kim GE, Cho JH, Yang WI, Chung EJ, Suh CO, Park KR, Hong WP, Park IY, Hahn JS, Roh JK and Kim BS: Angiocentric lymphoma of the head and neck: patterns of systemic failure after radiation treatment. J Clin Oncol. 18:54–63. 2000.PubMed/NCBI

3 

Lee J, Park YH, Kim WS, Lee SS, Ryoo BY, Yang SH, Park KW, Kang JH, Park JO, Lee SH, Kim K, Jung CW, Park YS, Im YH, Kang WK, Lee MH, Ko YH, Ahn YC and Park K: Extranodal nasal type NK/T-cell lymphoma: elucidating clinical prognostic factors for risk-based stratification of therapy. Eur J Cancer. 41:1402–1408. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Egger G, Liang G, Aparicio A and Jones PA: Epigenetics in human disease and prospects for epigenetic therapy. Nature. 429:457–463. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Kim TM, Park YH, Lee SY, Kim JH, Kim DW, Im SA, Kim TY, Kim CW, Heo DS, Bang YJ, Chang KH and Kim NK: Local tumor invasiveness is more predictive of survival than International Prognostic Index in stage I(E)/II(E) extranodal NK/T-cell lymphoma, nasal type. Blood. 106:3785–3790. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Lee J, Suh C, Park YH, Ko YH, Bang SM, Lee JH, Lee DH, Huh J, Oh SY, Kwon HC, Kim HJ, Lee SI, Kim JH, Park J, Oh SJ, Kim K, Jung C, Park K and Kim WS: Extranodal natural killer T-cell lymphoma, nasal-type: a prognostic model from a retrospective multicenter study. J Clin Oncol. 24:612–618. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Yamaguchi M: Current and future management of NK/T-cell lymphoma based on clinical trials. Int J Hematol. 96:562–571. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Ueno T, Ohtawa K, Mitsui K, Kodera Y, Hiroto M, Matsushima A, Inada Y and Nishimura H: Cell cycle arrest and apoptosis of leukemia cells induced by L-asparaginase. Leukemia. 11:1858–1861. 1997. View Article : Google Scholar : PubMed/NCBI

9 

Richards NG and Schuster SM: Mechanistic issues in asparagine synthetase catalysis. Adv Enzymol Relat Areas Mol Biol. 72:145–198. 1998.PubMed/NCBI

10 

Chen H, Pan YX, Dudenhausen EE and Kilberg MS: Amino acid deprivation induces the transcription rate of the human asparagine synthetase gene through a timed program of expression and promoter binding of nutrient-responsive bZIP transcription factors as well as localized histone acetylation. J Biol Chem. 279:50829–50839. 2004. View Article : Google Scholar

11 

Kilberg MS, Pan YX, Chen H and Leung-Pineda V: Nutritional control of gene expression: how mammalian cells respond to amino acid limitation. Annu Rev Nutr. 25:59–85. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Li BS, Gu LJ, Luo CY, Li WS, Jiang LM, Shen SH, Jiang H, Shen SH, Zhang B, Chen J, Xue HL and Tang JY: The downregulation of asparagine synthetase expression can increase the sensitivity of cells resistant to L-asparaginase. Leukemia. 20:2199–2201. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Hashimoto K, Suzuki F and Sakagami H: Declined asparagine synthetase mRNA expression and enhanced sensitivity to asparaginase in HL-60 cells committed to monocytic differentiation. Anticancer Res. 29:1303–1308. 2009.PubMed/NCBI

14 

Aslanian AM, Fletcher BS and Kilberg MS: Asparagine synthetase expression alone is sufficient to induce L-asparaginase resistance in MOLT-4 human leukaemia cells. Biochem J. 357:321–328. 2001. View Article : Google Scholar

15 

Zwaan CM, Kaspers GJ, Pieters R, Hahlen K, Janka-Schaub GE, van Zantwijk CH, Huismans DR, de Vries E, Rots MG, Peters GJ, Jansen G, Creutzig U and Veerman AJ: Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome. Blood. 99:245–251. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Lorenzi PL, Llamas J, Gunsior M, Ozbun L, Reinhold WC, Varma S, Ji H, Kim H, Hutchinson AA, Kohn EC, Goldsmith PK, Birrer MJ and Weinstein JN: Asparagine synthetase is a predictive biomarker of L-asparaginase activity in ovarian cancer cell lines. Mol Cancer Ther. 7:3123–3128. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Lorenzi PL, Reinhold WC, Rudelius M, Gunsior M, Shankavaram U, Bussey KJ, Scherf U, Eichler GS, Martin SE, Chin K, Gray JW, Kohn EC, Horak ID, Von Hoff DD, Raffeld M, Goldsmith PK, Caplen NJ and Weinstein JN: Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells. Mol Cancer Ther. 5:2613–2623. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Cui H, Darmanin S, Natsuisaka M, Kondo T, Asaka M, Shindoh M, Higashino F, Hamuro J, Okada F, Kobayashi M, Nakagawa K and Koide H: Enhanced expression of asparagine synthetase under glucose-deprived conditions protects pancreatic cancer cells from apoptosis induced by glucose deprivation and cisplatin. Cancer Res. 67:3345–3355. 2007. View Article : Google Scholar

19 

Sircar K, Huang H, Hu L, Cogdell D, Dhillon J, Tzelepi V, Efstathiou E, Koumakpayi IH, Saad F, Luo D, Bismar TA, Aparicio A, Troncoso P, Navone N and Zhang W: Integrative molecular profiling reveals asparagine synthetase is a target in castration-resistant prostate cancer. Am J Pathol. 180:895–903. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Zhang B, Dong LW, Tan YX, Zhang J, Pan YF, Yang C, Li MH, Ding ZW, Liu LJ, Jiang TY, Yang JH and Wang HY: Asparagine synthetase is an independent predictor of surgical survival and a potential therapeutic target in hepatocellular carcinoma. Br J Cancer. 109:14–23. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J and Vardiman JWL: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue (IARC WHO Classification of Tumours). IARC Press; Lyon: 2008

22 

Cheson BD, Pfistner B, Juweid ME, Gascoyne RD, Specht L, Horning SJ, Coiffier B, Fisher RI, Hagenbeek A, Zucca E, et al; International Harmonization Project on Lymphoma. Revised response criteria for malignant lymphoma. J Clin Oncol. 25:579–586. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Hutson RG, Kitoh T, Moraga Amador DA, Cosic S, Schuster SM and Kilberg MS: Amino acid control of asparagine synthetase: relation to asparagi-nase resistance in human leukemia cells. Am J Physiol. 272:1691–1699. 1997.PubMed/NCBI

24 

Balasubramanian MN, Butterworth EA and Kilberg MS: Asparagine synthetase: regulation by cell stress and involvement in tumor biology. Am J Physiol Endocrinol Metab. 304:789–799. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Fine BM, Kaspers GJ, Ho M, Loonen AH and Boxer LM: A genome-wide view of the in vitro response to L-asparaginase in acute lymphoblastic leukemia. Cancer Res. 65:291–299. 2005.PubMed/NCBI

26 

Stams WA, den Boer ML, Beverloo HB, Meijerink JP, Stigter RL, van Wering ER, Janka-Schaub GE, Slater R and Pieters R: Sensitivity to L-asparaginase is not associated with expression levels of asparagine synthetase in t(12; 21)+ pediatric ALL. Blood. 101:2743–2747. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Stams WA, den Boer ML, Holleman A, Appel IM, Beverloo HB, van Wering ER, Janka-Schaub GE, Evans WE and Pieters R: Asparagine synthetase expression is linked with L-asparaginase resistance in TEL-AML1-negative but not TEL-AML1-positive pediatric acute lymphoblastic leukemia. Blood. 105:4223–4225. 2005. View Article : Google Scholar

28 

Den Boer ML, Evans WE and Pieters R: TEL-AML1-positive ALL: a discordant genotype. Cell Cycle. 4:997–998. 2005.PubMed/NCBI

29 

Dufour E, Gay F, Aguera K, Scoazec JY, Horand F, Lorenzi PL and Godfrin Y: Pancreatic tumor sensitivity to plasma L-asparagine starvation. Pancreas. 41:940–948. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Tardito S, Chiu M, Uggeri J, Zerbini A, Da Ros F, Dall’Asta V, Missale G and Bussolati O: L-Asparaginase and inhibitors of glutamine synthetase disclose glutamine addiction of beta-catenin-mutated human hepatocellular carcinoma cells. Curr Cancer Drug Targets. 11:929–943. 2011. View Article : Google Scholar

31 

Greco A, Gong SS, Ittmann M and Basilico C: Organization and expression of the cell cycle gene, ts11, that encodes asparagine synthetase. Mol Cell Biol. 9:2350–2359. 1989.PubMed/NCBI

32 

Gong SS and Basilico C: A mammalian temperature-sensitive mutation affecting G1 progression results from a single amino acid substitution in asparagine synthetase. Nucleic Acids Res. 18:3509–3513. 1990. View Article : Google Scholar

33 

Patrikainen L, Porvari K, Kurkela R, Hirvikoski P, Soini Y and Vihko P: Expression profiling of PC-3 cell line variants and comparison of MIC-1 transcript levels in benign and malignant prostate. Eur J Clin Invest. 37:126–133. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Ameri K, Luong R, Zhang H, Powell AA, Montgomery KD, Espinosa I, Bouley DM, Harris AL and Jeffrey SS: Circulating tumour cells demonstrate an altered response to hypoxia and an aggressive phenotype. Br J Cancer. 102:561–569. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Zhang X, Hu T, Han L, Li R, Wen J and Zhang M: Asparagine synthetase expression and its potential prognostic value in patients with NK/T cell lymphoma. Oncol Rep 32: 853-859, 2014.
APA
Li, Y., Zhang, X., Hu, T., Han, L., Li, R., Wen, J., & Zhang, M. (2014). Asparagine synthetase expression and its potential prognostic value in patients with NK/T cell lymphoma. Oncology Reports, 32, 853-859. https://doi.org/10.3892/or.2014.3237
MLA
Li, Y., Zhang, X., Hu, T., Han, L., Li, R., Wen, J., Zhang, M."Asparagine synthetase expression and its potential prognostic value in patients with NK/T cell lymphoma". Oncology Reports 32.2 (2014): 853-859.
Chicago
Li, Y., Zhang, X., Hu, T., Han, L., Li, R., Wen, J., Zhang, M."Asparagine synthetase expression and its potential prognostic value in patients with NK/T cell lymphoma". Oncology Reports 32, no. 2 (2014): 853-859. https://doi.org/10.3892/or.2014.3237
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Zhang X, Hu T, Han L, Li R, Wen J and Zhang M: Asparagine synthetase expression and its potential prognostic value in patients with NK/T cell lymphoma. Oncol Rep 32: 853-859, 2014.
APA
Li, Y., Zhang, X., Hu, T., Han, L., Li, R., Wen, J., & Zhang, M. (2014). Asparagine synthetase expression and its potential prognostic value in patients with NK/T cell lymphoma. Oncology Reports, 32, 853-859. https://doi.org/10.3892/or.2014.3237
MLA
Li, Y., Zhang, X., Hu, T., Han, L., Li, R., Wen, J., Zhang, M."Asparagine synthetase expression and its potential prognostic value in patients with NK/T cell lymphoma". Oncology Reports 32.2 (2014): 853-859.
Chicago
Li, Y., Zhang, X., Hu, T., Han, L., Li, R., Wen, J., Zhang, M."Asparagine synthetase expression and its potential prognostic value in patients with NK/T cell lymphoma". Oncology Reports 32, no. 2 (2014): 853-859. https://doi.org/10.3892/or.2014.3237
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