Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
August-2014 Volume 32 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2014 Volume 32 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Differential promoter methylation of kinesin family member 1a in plasma is associated with breast cancer and DNA repair capacity

  • Authors:
    • Rafael Guerrero-Preston
    • Tal  Hadar
    • Kimberly  Laskie Ostrow
    • Ethan  Soudry
    • Miguel  Echenique
    • Carmen  Ili-Gangas
    • Gabriela  Pérez
    • Jimena  Perez
    • Priscilla  Brebi-Mieville
    • José  Deschamps
    • Luisa  Morales
    • Manuel  Bayona
    • David  Sidransky
    • Jaime  Matta
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology - Head and Neck Cancer Research Division, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA, Cancer Center, Auxilio Mutuo Hospital, San Juan, Puerto Rico, Department of Pharmacology and Toxicology, Ponce School of Medicine and Health Sciences, Ponce 00732-7004, Puerto Rico, Public Health Program, Ponce School of Medicine and Health Sciences, Ponce 00732-7004, Puerto Rico
    Copyright: © Guerrero-Preston et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 505-512
    |
    Published online on: June 13, 2014
       https://doi.org/10.3892/or.2014.3262
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Methylation alterations of CpG islands, CpG island shores and first exons are key events in the formation and progression of human cancer, and an increasing number of differentially methylated regions and genes have been identified in breast cancer. Recent studies of the breast cancer methylome using deep sequencing and microarray platforms are providing a novel insight on the different roles aberrant methylation plays in molecular subtypes of breast cancer. Accumulating evidence from a subset of studies suggests that promoter methylation of tumor-suppressor genes associated with breast cancer can be quantified in circulating DNA. However, there is a paucity of studies that examine the combined presence of genetic and epigenetic alterations associated with breast cancer using blood-based assays. Dysregulation of DNA repair capacity (DRC) is a genetic risk factor for breast cancer that has been measured in lymphocytes. We isolated plasma DNA from 340 participants in a breast cancer case control project to study promoter methylation levels of five genes previously shown to be associated with breast cancer in frozen tissue and in cell line DNA: MAL, KIF1A, FKBP4, VGF and OGDHL. Methylation of at least one gene was found in 49% of the cases compared to 20% of the controls. Three of the four genes had receiver characteristic operator curve values of ≥0.50: MAL (0.64), KIF1A (0.51) and OGDHL (0.53). KIF1A promoter methylation was associated with breast cancer and inversely associated with DRC. This is the first evidence of a significant association between genetic and epigenetic alterations in breast cancer using blood-based tests. The potential diagnostic utility of these biomarkers and their relevance for breast cancer risk prediction should be examined in larger cohorts.
View Figures
View References

1 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Forouzanfar MH, Foreman KJ, Delossantos AM, et al: Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis. Lancet. 378:1461–1484. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Bray F, Ren JS, Masuyer E and Ferlay J: Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer. 132:1133–1145. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Figueroa-Vallés NR, Ortiz-Ortiz KJ, Pérez-Ríos N, Villanueva-Rosa E, Traverso-Ortiz M, Torres-Cintrón CR and Suárez-Ramos T: Cancer in Puerto Rico, 2004–2009. Puerto Rico Central Cancer Registry; San Juan: 2012

5 

Gøtzsche PC: Mammography screening: truth, lies, and controversy. Lancet. 380:2182012.PubMed/NCBI

6 

Ogino S, Lochhead P, Chan AT, et al: Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease. Mod Pathol. 26:465–484. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Ostrow KL, Park HL, Hoque MO, et al: Pharmacologic unmasking of epigenetically silenced genes in breast cancer. Clin Cancer Res. 15:1184–1191. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Kim GE, Lee KH, Choi YD, et al: Detection of Slit2 promoter hypermethylation in tissue and serum samples from breast cancer patients. Virchows Arch. 459:383–390. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Ramos JM, Ruiz A, Colen R, Lopez ID, Grossman L and Matta JL: DNA repair and breast carcinoma susceptibility in women. Cancer. 100:1352–1357. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Matta JL, Villa JL, Ramos JM, et al: DNA repair and nonmelanoma skin cancer in Puerto Rican populations. J Am Acad Dermatol. 49:433–439. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Matta J, Echenique M, Negron E, et al: The association of DNA repair with breast cancer risk in women. A comparative observational study. BMC Cancer. 12:4902012. View Article : Google Scholar : PubMed/NCBI

12 

Morales L, Alvarez-Garriga C, Matta J, et al: Factors associated with breast cancer in Puerto Rican women. J Epidemiol Glob Health. 3:205–215. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Hoque MO, Begum S, Topaloglu O, et al: Quantitation of promoter methylation of multiple genes in urine DNA and bladder cancer detection. J Natl Cancer Inst. 98:996–1004. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Rosner B: Fundamentals of Biostatistics. 7th edition. Brooks/Cole; Boston, MA: 2010

15 

Szklo MNJ: Epidemiology Beyond the Basics. Jones and Bartlett Learning; Burlington, MA: 2006

16 

Lo KY, Kuzmin A, Unger SM, Petersen JD and Silverman MA: KIF1A is the primary anterograde motor protein required for the axonal transport of dense-core vesicles in cultured hippocampal neurons. Neurosci Lett. 491:168–173. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Brait M, Loyo M, Rosenbaum E, et al: Correlation between BRAF mutation and promoter methylation of TIMP3, RARβ2 and RASSF1A in thyroid cancer. Epigenetics. 7:710–719. 2012.

18 

Roh JL, Wang XV, Manola J, Sidransky D, Forastiere AA and Koch WM: Clinical correlates of promoter hypermethylation of four target genes in head and neck cancer: a cooperative group correlative study. Clin Cancer Res. 19:2528–2540. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Ostrow KL, Hoque MO, Loyo M, et al: Molecular analysis of plasma DNA for the early detection of lung cancer by quantitative methylation-specific PCR. Clin Cancer Res. 16:3463–3472. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Demokan S, Chang X, Chuang A, et al: KIF1A and EDNRB are differentially methylated in primary HNSCC and salivary rinses. Int J Cancer. 127:2351–2359. 2010. View Article : Google Scholar : PubMed/NCBI

21 

De S, Cipriano R, Jackson MW and Stark GR: Overexpression of kinesins mediates docetaxel resistance in breast cancer cells. Cancer Res. 69:8035–8042. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Horne HN, Lee PS, Murphy SK, Alonso MA, Olson JA Jr and Marks JR: Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy. Mol Cancer Res. 7:199–209. 2009.

23 

Suzuki M, Shiraishi K, Eguchi A, et al: Aberrant methylation of LINE-1, SLIT2, MAL and IGFBP7 in non-small cell lung cancer. Oncol Rep. 29:1308–1314. 2013.PubMed/NCBI

24 

Lind GE, Danielsen SA, Ahlquist T, et al: Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas. Mol Cancer. 10:852011. View Article : Google Scholar : PubMed/NCBI

25 

Galigniana MD, Harrell JM, O‘Hagen HM, Ljungman M and Pratt WB: Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus. J Biol Chem. 279:22483–22489. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Lin JF, Xu J, Tian HY, et al: Identification of candidate prostate cancer biomarkers in prostate needle biopsy specimens using proteomic analysis. Int J Cancer. 121:2596–2605. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Ward BK, Mark PJ, Ingram DM, Minchin RF and Ratajczak T: Expression of the estrogen receptor-associated immunophilins, cyclophilin 40 and FKBP52, in breast cancer. Breast Cancer Res Treat. 58:267–280. 1999.PubMed/NCBI

28 

Levi A, Ferri GL, Watson E, Possenti R and Salton SR: Processing, distribution, and function of VGF, a neuronal and endocrine peptide precursor. Cell Mol Neurobiol. 24:517–533. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Ferri GL, Noli B, Brancia C, D‘Amato F and Cocco C: VGF: an inducible gene product, precursor of a diverse array of neuro-endocrine peptides and tissue-specific disease biomarkers. J Chem Neuroanat. 42:249–261. 2011. View Article : Google Scholar

30 

Brait M, Maldonado L, Noordhuis MG, et al: Association of promoter methylation of VGF and PGP9.5 with ovarian cancer progression. PLoS One. 8:e708782013.PubMed/NCBI

31 

Brait M, Maldonado L, Begum S, et al: DNA methylation profiles delineate epigenetic heterogeneity in seminoma and non-seminoma. Br J Cancer. 106:414–423. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Sen T, Sen N, Noordhuis MG, et al: OGDHL is a modifier of AKT-dependent signaling and NF-κB function. PLoS One. 7:e487702012.PubMed/NCBI

33 

Lahtz C and Pfeifer GP: Epigenetic changes of DNA repair genes in cancer. J Mol Cell Biol. 3:51–58. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Leary AF, Castro DG, Nicholson AG, et al: Establishing an EGFR mutation screening service for non-small cell lung cancer - sample quality criteria and candidate histological predictors. Eur J Cancer. 48:61–67. 2012.

35 

Silva JM, Dominguez G, Garcia JM, et al: Presence of tumor DNA in plasma of breast cancer patients: clinicopathological correlations. Cancer Res. 59:3251–3256. 1999.PubMed/NCBI

36 

Hoque MO, Feng Q, Toure P, et al: Detection of aberrant methylation of four genes in plasma DNA for the detection of breast cancer. J Clin Oncol. 24:4262–4269. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Heichman KA and Warren JD: DNA methylation biomarkers and their utility for solid cancer diagnostics. Clin Chem Lab Med. 50:1707–1721. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Latimer JJ, Johnson JM, Kelly CM, et al: Nucleotide excision repair deficiency is intrinsic in sporadic stage I breast cancer. Proc Natl Acad Sci USA. 107:21725–21730. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Li L: Nucleotide excision repair. DNA Repair, Genetic Instability and Cancer. Wei Q, Lei L and Chen DJ: World Scientific; Singapore: pp. 65–86. 2007, View Article : Google Scholar

40 

Berwick M and Vineis P: Measuring DNA repair capacity: small steps. J Natl Cancer Inst. 97:84–85. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Curtin N: PARP inhibitors for anticancer therapy. Biochem Soc Trans. 42:82–88. 2014. View Article : Google Scholar

42 

Eccles SA, Aboagye EO, Ali S, et al: Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Res. 15:R922013. View Article : Google Scholar : PubMed/NCBI

43 

Glendenning J and Tutt A: PARP inhibitors - current status and the walk towards early breast cancer. Breast. 20(Suppl 3): S12–S19. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Guerrero-Preston R, Hadar T, Ostrow KL, Soudry E, Echenique M, Ili-Gangas C, Pérez G, Perez J, Brebi-Mieville P, Deschamps J, Deschamps J, et al: Differential promoter methylation of kinesin family member 1a in plasma is associated with breast cancer and DNA repair capacity. Oncol Rep 32: 505-512, 2014.
APA
Guerrero-Preston, R., Hadar, T., Ostrow, K.L., Soudry, E., Echenique, M., Ili-Gangas, C. ... Matta, J. (2014). Differential promoter methylation of kinesin family member 1a in plasma is associated with breast cancer and DNA repair capacity. Oncology Reports, 32, 505-512. https://doi.org/10.3892/or.2014.3262
MLA
Guerrero-Preston, R., Hadar, T., Ostrow, K. L., Soudry, E., Echenique, M., Ili-Gangas, C., Pérez, G., Perez, J., Brebi-Mieville, P., Deschamps, J., Morales, L., Bayona, M., Sidransky, D., Matta, J."Differential promoter methylation of kinesin family member 1a in plasma is associated with breast cancer and DNA repair capacity". Oncology Reports 32.2 (2014): 505-512.
Chicago
Guerrero-Preston, R., Hadar, T., Ostrow, K. L., Soudry, E., Echenique, M., Ili-Gangas, C., Pérez, G., Perez, J., Brebi-Mieville, P., Deschamps, J., Morales, L., Bayona, M., Sidransky, D., Matta, J."Differential promoter methylation of kinesin family member 1a in plasma is associated with breast cancer and DNA repair capacity". Oncology Reports 32, no. 2 (2014): 505-512. https://doi.org/10.3892/or.2014.3262
Copy and paste a formatted citation
x
Spandidos Publications style
Guerrero-Preston R, Hadar T, Ostrow KL, Soudry E, Echenique M, Ili-Gangas C, Pérez G, Perez J, Brebi-Mieville P, Deschamps J, Deschamps J, et al: Differential promoter methylation of kinesin family member 1a in plasma is associated with breast cancer and DNA repair capacity. Oncol Rep 32: 505-512, 2014.
APA
Guerrero-Preston, R., Hadar, T., Ostrow, K.L., Soudry, E., Echenique, M., Ili-Gangas, C. ... Matta, J. (2014). Differential promoter methylation of kinesin family member 1a in plasma is associated with breast cancer and DNA repair capacity. Oncology Reports, 32, 505-512. https://doi.org/10.3892/or.2014.3262
MLA
Guerrero-Preston, R., Hadar, T., Ostrow, K. L., Soudry, E., Echenique, M., Ili-Gangas, C., Pérez, G., Perez, J., Brebi-Mieville, P., Deschamps, J., Morales, L., Bayona, M., Sidransky, D., Matta, J."Differential promoter methylation of kinesin family member 1a in plasma is associated with breast cancer and DNA repair capacity". Oncology Reports 32.2 (2014): 505-512.
Chicago
Guerrero-Preston, R., Hadar, T., Ostrow, K. L., Soudry, E., Echenique, M., Ili-Gangas, C., Pérez, G., Perez, J., Brebi-Mieville, P., Deschamps, J., Morales, L., Bayona, M., Sidransky, D., Matta, J."Differential promoter methylation of kinesin family member 1a in plasma is associated with breast cancer and DNA repair capacity". Oncology Reports 32, no. 2 (2014): 505-512. https://doi.org/10.3892/or.2014.3262
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team