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Article Open Access

GPC3 expression in mouse ovarian cancer induces GPC3‑specific T cell-mediated immune response through M1 macrophages and suppresses tumor growth

  • Authors:
    • Chenhong Luo
    • Kiyosumi Shibata
    • Shiro Suzuki
    • Hiroaki Kajiyama
    • Takeshi  Senga
    • Yoshihiro Koya
    • Mina Daimon
    • Mamoru Yamashita
    • Fumitaka Kikkawa
  • View Affiliations / Copyright

    Affiliations: Bio-Databases Institute of Reproductive and Developmental Medicine, Nagoya 458-0818, Japan, Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya 466‑8550, Japan, Department of Cancer Biology, Nagoya University School of Medicine, Nagoya 466‑8550, Japan, Bell Research Center for Reproductive Health and Cancer, Nagoya 458-0818, Japan
    Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 913-921
    |
    Published online on: July 2, 2014
       https://doi.org/10.3892/or.2014.3300
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Abstract

Glypican-3 (GPC3) is specifically expressed in ovarian clear cell carcinoma (OCCC), hepatocellular carci­noma (HCC), and melanoma and lung cancer. GPC3 is being explored as a potential candidate for OCCC and HCC immunotherapy. As a tumor-associated antigen, induction of immune response of GPC3 in ovarian cancer remains elusive. We established a GPC3 transgenic mouse ovarian cancer cell line, OV2944-HM-1 (HM-1), and used the intraperitoneal ovarian cancer mouse model to investigate immune response in GPC3-expressing tumor. We found that GPC3 expression in the tumor increased F4/80+CD86+ macrophage (M1) proportion and caused GPC3-specific CD8+ T cell immune responses, and prolonged mouse survival. Our results demonstrated that GPC3 expression induced T cell-mediated immune response in this mouse ovarian cancer model and also provided supportive evidence that GPC3 is an ideal target for ovarian cancer immunotherapy.
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Copy and paste a formatted citation
Spandidos Publications style
Luo C, Shibata K, Suzuki S, Kajiyama H, Senga T, Koya Y, Daimon M, Yamashita M and Kikkawa F: GPC3 expression in mouse ovarian cancer induces GPC3‑specific T cell-mediated immune response through M1 macrophages and suppresses tumor growth. Oncol Rep 32: 913-921, 2014.
APA
Luo, C., Shibata, K., Suzuki, S., Kajiyama, H., Senga, T., Koya, Y. ... Kikkawa, F. (2014). GPC3 expression in mouse ovarian cancer induces GPC3‑specific T cell-mediated immune response through M1 macrophages and suppresses tumor growth. Oncology Reports, 32, 913-921. https://doi.org/10.3892/or.2014.3300
MLA
Luo, C., Shibata, K., Suzuki, S., Kajiyama, H., Senga, T., Koya, Y., Daimon, M., Yamashita, M., Kikkawa, F."GPC3 expression in mouse ovarian cancer induces GPC3‑specific T cell-mediated immune response through M1 macrophages and suppresses tumor growth". Oncology Reports 32.3 (2014): 913-921.
Chicago
Luo, C., Shibata, K., Suzuki, S., Kajiyama, H., Senga, T., Koya, Y., Daimon, M., Yamashita, M., Kikkawa, F."GPC3 expression in mouse ovarian cancer induces GPC3‑specific T cell-mediated immune response through M1 macrophages and suppresses tumor growth". Oncology Reports 32, no. 3 (2014): 913-921. https://doi.org/10.3892/or.2014.3300
Copy and paste a formatted citation
x
Spandidos Publications style
Luo C, Shibata K, Suzuki S, Kajiyama H, Senga T, Koya Y, Daimon M, Yamashita M and Kikkawa F: GPC3 expression in mouse ovarian cancer induces GPC3‑specific T cell-mediated immune response through M1 macrophages and suppresses tumor growth. Oncol Rep 32: 913-921, 2014.
APA
Luo, C., Shibata, K., Suzuki, S., Kajiyama, H., Senga, T., Koya, Y. ... Kikkawa, F. (2014). GPC3 expression in mouse ovarian cancer induces GPC3‑specific T cell-mediated immune response through M1 macrophages and suppresses tumor growth. Oncology Reports, 32, 913-921. https://doi.org/10.3892/or.2014.3300
MLA
Luo, C., Shibata, K., Suzuki, S., Kajiyama, H., Senga, T., Koya, Y., Daimon, M., Yamashita, M., Kikkawa, F."GPC3 expression in mouse ovarian cancer induces GPC3‑specific T cell-mediated immune response through M1 macrophages and suppresses tumor growth". Oncology Reports 32.3 (2014): 913-921.
Chicago
Luo, C., Shibata, K., Suzuki, S., Kajiyama, H., Senga, T., Koya, Y., Daimon, M., Yamashita, M., Kikkawa, F."GPC3 expression in mouse ovarian cancer induces GPC3‑specific T cell-mediated immune response through M1 macrophages and suppresses tumor growth". Oncology Reports 32, no. 3 (2014): 913-921. https://doi.org/10.3892/or.2014.3300
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