Open Access

GPC3 expression in mouse ovarian cancer induces GPC3‑specific T cell-mediated immune response through M1 macrophages and suppresses tumor growth

  • Authors:
    • Chenhong Luo
    • Kiyosumi Shibata
    • Shiro Suzuki
    • Hiroaki Kajiyama
    • Takeshi  Senga
    • Yoshihiro Koya
    • Mina Daimon
    • Mamoru Yamashita
    • Fumitaka Kikkawa
  • View Affiliations

  • Published online on: July 2, 2014     https://doi.org/10.3892/or.2014.3300
  • Pages: 913-921
  • Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Glypican-3 (GPC3) is specifically expressed in ovarian clear cell carcinoma (OCCC), hepatocellular carci­noma (HCC), and melanoma and lung cancer. GPC3 is being explored as a potential candidate for OCCC and HCC immunotherapy. As a tumor-associated antigen, induction of immune response of GPC3 in ovarian cancer remains elusive. We established a GPC3 transgenic mouse ovarian cancer cell line, OV2944-HM-1 (HM-1), and used the intraperitoneal ovarian cancer mouse model to investigate immune response in GPC3-expressing tumor. We found that GPC3 expression in the tumor increased F4/80+CD86+ macrophage (M1) proportion and caused GPC3-specific CD8+ T cell immune responses, and prolonged mouse survival. Our results demonstrated that GPC3 expression induced T cell-mediated immune response in this mouse ovarian cancer model and also provided supportive evidence that GPC3 is an ideal target for ovarian cancer immunotherapy.
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September-2014
Volume 32 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Luo C, Shibata K, Suzuki S, Kajiyama H, Senga T, Koya Y, Daimon M, Yamashita M and Kikkawa F: GPC3 expression in mouse ovarian cancer induces GPC3‑specific T cell-mediated immune response through M1 macrophages and suppresses tumor growth. Oncol Rep 32: 913-921, 2014
APA
Luo, C., Shibata, K., Suzuki, S., Kajiyama, H., Senga, T., Koya, Y. ... Kikkawa, F. (2014). GPC3 expression in mouse ovarian cancer induces GPC3‑specific T cell-mediated immune response through M1 macrophages and suppresses tumor growth. Oncology Reports, 32, 913-921. https://doi.org/10.3892/or.2014.3300
MLA
Luo, C., Shibata, K., Suzuki, S., Kajiyama, H., Senga, T., Koya, Y., Daimon, M., Yamashita, M., Kikkawa, F."GPC3 expression in mouse ovarian cancer induces GPC3‑specific T cell-mediated immune response through M1 macrophages and suppresses tumor growth". Oncology Reports 32.3 (2014): 913-921.
Chicago
Luo, C., Shibata, K., Suzuki, S., Kajiyama, H., Senga, T., Koya, Y., Daimon, M., Yamashita, M., Kikkawa, F."GPC3 expression in mouse ovarian cancer induces GPC3‑specific T cell-mediated immune response through M1 macrophages and suppresses tumor growth". Oncology Reports 32, no. 3 (2014): 913-921. https://doi.org/10.3892/or.2014.3300