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Article

Bone morphogenetic protein 2 inhibits the proliferation and growth of human colorectal cancer cells

  • Authors:
    • Yunyuan Zhang
    • Xian Chen
    • Min Qiao
    • Bing-Qiang Zhang
    • Ning Wang
    • Zhonglin Zhang
    • Zhan Liao
    • Liyi Zeng
    • Youlin Deng
    • Fang Deng
    • Junhui Zhang
    • Liangjun Yin
    • Wei Liu
    • Qian Zhang
    • Zhengjian Ya
    • Jixing Ye
    • Zhongliang Wang
    • Lan Zhou
    • Hue H. Luu
    • Rex C. Haydon
    • Tong-Chuan He
    • Hongyu Zhang
  • View Affiliations / Copyright

    Affiliations: Ministry of Education Key Laboratory of Clinical Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical University, Chongqing 400016, P.R. China, Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, IL 60637, USA
  • Pages: 1013-1020
    |
    Published online on: July 3, 2014
       https://doi.org/10.3892/or.2014.3308
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Abstract

Colorectal cancer (CRC) is one of the most deadly cancers worldwide. Significant progress has been made in understanding the molecular pathogenesis of CRC, which has led to successful early diagnosis, surgical intervention and combination chemotherapy. However, limited therapeutic options are available for metastatic and/or drug-resistant CRC. While the aberrantly activated Wnt/β-catenin pathway plays a critical initiating role in CRC development, disruption of the bone morphogenetic protein (BMP) pathway causes juvenile polyposis syndrome, suggesting that BMP signaling may play a role in CRC development. However, conflicting results have been reported concerning the possible roles of BMP signaling in sporadic colon cancer. Here, we investigated the effect of BMP2 on the proliferation, migration, invasiveness and tumor growth capability of human CRC cells. Using an adenovirus vector that overexpresses BMP2 and the piggyBac transposon-mediated stable BMP2 overexpression CRC line, we found that exogenous BMP2 effectively inhibited HCT116 cell proliferation and colony formation. BMP2 was shown to suppress colon cancer cell migration and invasiveness. Under a low serum culture condition, forced expression of BMP2 induced a significantly increased level of apoptosis in HCT116 cells. Using a xenograft tumor model, we found that forced expression of BMP2 in HCT116 cells suppressed tumor growth, accompanied by decreased cell proliferation activity. Taken together, our results strongly suggest that BMP2 plays an important inhibitory role in governing the proliferation and aggressive features of human CRC cells.
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View References

1 

Bertrand FE, Angus CW, Partis WJ and Sigounas G: Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and Notch. Cell Cycle. 11:4344–4351. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar

3 

Kinzler KW and Vogelstein B: Lessons from hereditary colorectal cancer. Cell. 87:159–170. 1996. View Article : Google Scholar : PubMed/NCBI

4 

Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA Jr and Kinzler KW: Cancer genome landscapes. Science. 339:1546–1558. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Kinzler KW, Nilbert MC, Su LK, et al: Identification of FAP locus genes from chromosome 5q21. Science. 253:661–665. 1991. View Article : Google Scholar : PubMed/NCBI

6 

Chan TL, Zhao W, Leung SY and Yuen ST: BRAF and KRAS mutations in colorectal hyperplastic polyps and serrated adenomas. Cancer Res. 63:4878–4881. 2003.PubMed/NCBI

7 

Hardwick JC, Kodach LL, Offerhaus GJ and van den Brink GR: Bone morphogenetic protein signalling in colorectal cancer. Nat Rev Cancer. 8:806–812. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Massague J: TGF-beta signal transduction. Annu Rev Biochem. 67:753–791. 1998. View Article : Google Scholar

9 

Massague J: How cells read TGF-beta signals. Nat Rev Mol Cell Biol. 1:169–178. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Thiagalingam S, Lengauer C, Leach FS, et al: Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. Nat Genet. 13:343–346. 1996. View Article : Google Scholar : PubMed/NCBI

11 

Howe JR, Bair JL, Sayed MG, et al: Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nat Genet. 28:184–187. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Howe JR, Roth S, Ringold JC, et al: Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science. 280:1086–1088. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Howe JR, Sayed MG, Ahmed AF, et al: The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations. J Med Genet. 41:484–491. 2004.PubMed/NCBI

14 

Sayed MG, Ahmed AF, Ringold JR, et al: Germline SMAD4 or BMPR1A mutations and phenotype of juvenile polyposis. Ann Surg Oncol. 9:901–906. 2002.PubMed/NCBI

15 

Haramis AP, Begthel H, van den Born M, et al: De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science. 303:1684–1686. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Hardwick JC, Van Den Brink GR, Bleuming SA, et al: Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon. Gastroenterology. 126:111–121. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Loh K, Chia JA, Greco S, et al: Bone morphogenic protein 3 inactivation is an early and frequent event in colorectal cancer development. Genes Chromosomes Cancer. 47:449–460. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Beck SE, Jung BH, Fiorino A, et al: Bone morphogenetic protein signaling and growth suppression in colon cancer. Am J Physiol Gastrointest Liver Physiol. 291:G135–G145. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Deng H, Makizumi R, Ravikumar TS, Dong H, Yang W and Yang WL: Bone morphogenetic protein-4 is overexpressed in colonic adenocarcinomas and promotes migration and invasion of HCT116 cells. Exp Cell Res. 313:1033–1044. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Motoyama K, Tanaka F, Kosaka Y, et al: Clinical significance of BMP7 in human colorectal cancer. Ann Surg Oncol. 15:1530–1537. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Lorente-Trigos A, Varnat F, Melotti A and Ruiz i Altaba A: BMP signaling promotes the growth of primary human colon carcinomas in vivo. J Mol Cell Biol. 2:318–332. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Luo X, Chen J, Song WX, et al: Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects. Lab Invest. 88:1264–1277. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Tang N, Song WX, Luo J, et al: BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/beta-catenin signaling. J Cell Mol Med. 13:2448–2464. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Gao Y, Huang E, Zhang H, et al: Crosstalk between Wnt/β-catenin and estrogen receptor signaling synergistically promotes osteogenic differentiation of mesenchymal progenitor cells. PloS One. 8:e824362013.

25 

Kong Y, Zhang H, Chen X, et al: Destabilization of heterologous proteins mediated by the GSK3β phosphorylation domain of the β-catenin protein. Cell Physiol Biochem. 32:1187–1199. 2013.PubMed/NCBI

26 

Zhang W, Zhang H, Wang N, et al: Modulation of β-catenin signaling by the inhibitors of MAP kinase, tyrosine kinase, and PI3-kinase pathways. Int J Med Sci. 10:1888–1898. 2013.

27 

Chen X, Luther G, Zhang W, et al: The E–F hand calcium-binding protein S100A4 regulates the proliferation, survival and differentiation potential of human osteosarcoma Cells. Cell Physiol Biochem. 32:1083–1096. 2013.

28 

Cheng H, Jiang W, Phillips FM, et al: Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs. J Bone Joint Surg Am. 85-A:1544–1552. 2003.PubMed/NCBI

29 

He TC, Zhou S, da Costa LT, Yu J, Kinzler KW and Vogelstein B: A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA. 95:2509–2514. 1998. View Article : Google Scholar : PubMed/NCBI

30 

Kang Q, Song WX, Luo Q, et al: A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells Dev. 18:545–559. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Kang Q, Sun MH, Cheng H, et al: Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. Gene Ther. 11:1312–1320. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Luo J, Deng ZL, Luo X, et al: A protocol for rapid generation of recombinant adenoviruses using the AdEasy system. Nat Protoc. 2:1236–1247. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Luu HH, Kang Q, Park JK, et al: An orthotopic model of human osteosarcoma growth and spontaneous pulmonary metastasis. Clin Exp Metastasis. 22:319–329. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Luu HH, Zhou L, Haydon RC, et al: Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma. Cancer Lett. 229:135–148. 2005. View Article : Google Scholar : PubMed/NCBI

35 

He BC, Gao JL, Luo X, et al: Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/β-catenin signaling. Int J Oncol. 38:437–445. 2011.PubMed/NCBI

36 

He BC, Gao JL, Zhang BQ, et al: Tetrandrine inhibits Wnt/β-catenin signaling and suppresses tumor growth of human colorectal cancer. Mol Pharmacol. 79:211–219. 2011.

37 

Su Y, Luo X, He BC, et al: Establishment and characterization of a new highly metastatic human osteosarcoma cell line. Clin Exp Metastasis. 26:599–610. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Su Y, Wagner ER, Luo Q, et al: Insulin-like growth factor binding protein 5 suppresses tumor growth and metastasis of human osteosarcoma. Oncogene. 30:3907–3917. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Wang J, Zhang H, Zhang W, et al: Bone morphogenetic protein-9 (BMP9) effectively induces osteo/odontoblastic differentiation of the reversibly immortalized stem cells of dental apical papilla. Stem Cells Dev. Mar 21–2014.(Epub ahead of print).

40 

Luo Q, Kang Q, Si W, et al: Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells. J Biol Chem. 279:55958–55968. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Luther GA, Lamplot J, Chen X, et al: IGFBP5 domains exert distinct inhibitory effects on the tumorigenicity and metastasis of human osteosarcoma. Cancer Lett. 336:222–230. 2013. View Article : Google Scholar : PubMed/NCBI

42 

He BC, Chen L, Zuo GW, et al: Synergistic antitumor effect of the activated PPARgamma and retinoid receptors on human osteosarcoma. Clin Cancer Res. 16:2235–2245. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Sharff KA, Song WX, Luo X, et al: Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells. J Biol Chem. 284:649–659. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Chen L, Jiang W, Huang J, et al: Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation. J Bone Miner Res. 25:2447–2459. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Zhang W, Deng ZL, Chen L, et al: Retinoic acids potentiate BMP9-induced osteogenic differentiation of mesenchymal progenitor cells. PloS One. 5:e119172010. View Article : Google Scholar : PubMed/NCBI

46 

Luo J, Tang M, Huang J, et al: TGFbeta/BMP type I receptors ALK1 and ALK2 are essential for BMP9-induced osteogenic signaling in mesenchymal stem cells. J Biol Chem. 285:29588–29598. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Slattery ML, Lundgreen A, Herrick JS, Wolff RK and Caan BJ: Genetic variation in the transforming growth factor-β signaling pathway and survival after diagnosis with colon and rectal cancer. Cancer. 117:4175–4183. 2011.

48 

Slattery ML, Lundgreen A, Herrick JS, et al: Genetic variation in bone morphogenetic protein and colon and rectal cancer. Int J Cancer. 130:653–664. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Xiang L, Wang S, Jin X, Duan W, Ding X and Zheng C: Expression of BMP2, TLR3, TLR4 and COX2 in colorectal polyps, adenoma and adenocarcinoma. Mol Med Rep. 6:973–976. 2012.PubMed/NCBI

50 

Kodach LL, Jacobs RJ, Voorneveld PW, et al: Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell ‘stemness’ via the bone morphogenetic protein pathway. Gut. 60:1544–1553. 2011.PubMed/NCBI

51 

Beck SE, Jung BH, Del Rosario E, Gomez J and Carethers JM: BMP-induced growth suppression in colon cancer cells is mediated by p21WAF1stabilization and modulated by RAS/ERK. Cell Signal. 19:1465–1472. 2007. View Article : Google Scholar : PubMed/NCBI

52 

Kang MH, Kang HN, Kim JL, Kim JS, Oh SC and Yoo YA: Inhibition of PI3 kinase/Akt pathway is required for BMP2-induced EMT and invasion. Oncol Rep. 22:525–534. 2009.PubMed/NCBI

53 

Wu WK, Sung JJ, Wu YC, Li ZJ, Yu L and Cho CH: Bone morphogenetic protein signalling is required for the anti-mitogenic effect of the proteasome inhibitor MG-132 on colon cancer cells. Br J Pharmacol. 154:632–638. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Chen X, Qiao M, Zhang B, Wang N, Zhang Z, Liao Z, Zeng L, Deng Y, Deng F, Deng F, et al: Bone morphogenetic protein 2 inhibits the proliferation and growth of human colorectal cancer cells. Oncol Rep 32: 1013-1020, 2014.
APA
Zhang, Y., Chen, X., Qiao, M., Zhang, B., Wang, N., Zhang, Z. ... Zhang, H. (2014). Bone morphogenetic protein 2 inhibits the proliferation and growth of human colorectal cancer cells. Oncology Reports, 32, 1013-1020. https://doi.org/10.3892/or.2014.3308
MLA
Zhang, Y., Chen, X., Qiao, M., Zhang, B., Wang, N., Zhang, Z., Liao, Z., Zeng, L., Deng, Y., Deng, F., Zhang, J., Yin, L., Liu, W., Zhang, Q., Ya, Z., Ye, J., Wang, Z., Zhou, L., Luu, H. H., Haydon, R. C., He, T., Zhang, H."Bone morphogenetic protein 2 inhibits the proliferation and growth of human colorectal cancer cells". Oncology Reports 32.3 (2014): 1013-1020.
Chicago
Zhang, Y., Chen, X., Qiao, M., Zhang, B., Wang, N., Zhang, Z., Liao, Z., Zeng, L., Deng, Y., Deng, F., Zhang, J., Yin, L., Liu, W., Zhang, Q., Ya, Z., Ye, J., Wang, Z., Zhou, L., Luu, H. H., Haydon, R. C., He, T., Zhang, H."Bone morphogenetic protein 2 inhibits the proliferation and growth of human colorectal cancer cells". Oncology Reports 32, no. 3 (2014): 1013-1020. https://doi.org/10.3892/or.2014.3308
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Chen X, Qiao M, Zhang B, Wang N, Zhang Z, Liao Z, Zeng L, Deng Y, Deng F, Deng F, et al: Bone morphogenetic protein 2 inhibits the proliferation and growth of human colorectal cancer cells. Oncol Rep 32: 1013-1020, 2014.
APA
Zhang, Y., Chen, X., Qiao, M., Zhang, B., Wang, N., Zhang, Z. ... Zhang, H. (2014). Bone morphogenetic protein 2 inhibits the proliferation and growth of human colorectal cancer cells. Oncology Reports, 32, 1013-1020. https://doi.org/10.3892/or.2014.3308
MLA
Zhang, Y., Chen, X., Qiao, M., Zhang, B., Wang, N., Zhang, Z., Liao, Z., Zeng, L., Deng, Y., Deng, F., Zhang, J., Yin, L., Liu, W., Zhang, Q., Ya, Z., Ye, J., Wang, Z., Zhou, L., Luu, H. H., Haydon, R. C., He, T., Zhang, H."Bone morphogenetic protein 2 inhibits the proliferation and growth of human colorectal cancer cells". Oncology Reports 32.3 (2014): 1013-1020.
Chicago
Zhang, Y., Chen, X., Qiao, M., Zhang, B., Wang, N., Zhang, Z., Liao, Z., Zeng, L., Deng, Y., Deng, F., Zhang, J., Yin, L., Liu, W., Zhang, Q., Ya, Z., Ye, J., Wang, Z., Zhou, L., Luu, H. H., Haydon, R. C., He, T., Zhang, H."Bone morphogenetic protein 2 inhibits the proliferation and growth of human colorectal cancer cells". Oncology Reports 32, no. 3 (2014): 1013-1020. https://doi.org/10.3892/or.2014.3308
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