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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2014 Volume 32 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Influence of mutation type on prognostic and predictive values of TP53 status in primary breast cancer patients

  • Authors:
    • Petr Dobes
    • Jan Podhorec
    • Oldrich  Coufal
    • Andrea  Jureckova
    • Katarina  Petrakova
    • Borivoj  Vojtesek
    • Roman Hrstka
  • View Affiliations / Copyright

    Affiliations: Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Zluty kopec 7, Brno 656 53, Czech Republic, Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Zluty kopec 7, Brno 656 53, Czech Republic
  • Pages: 1695-1702
    |
    Published online on: July 21, 2014
       https://doi.org/10.3892/or.2014.3346
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Abstract

High rates of mutation in the TP53 tumor suppressor gene have been found in many human cancers, including breast tumors, making p53 one of the most studied proteins in oncology. However, the prognostic and predictive value of alterations in this gene remains ambiguous. To analyze the clinical value of somatic TP53 mutations, we collected clinical and molecular data on 210 women with primary breast cancer. We found significant associations of p53 mutations with tumor grade, metastasis, molecular subtype, Her2 status and inverse correlations with estrogen and progesterone receptor status. Cox proportional hazard analysis confirmed a strong prognostic value of p53 mutation for overall survival rate and highlighted significant interactions with lymph node involvement and tumor size. In relation to treatment options, TP53 mutations were associated with poor response to anthracyclines and radiotherapy. Categorization of TP53 mutations according to their type and location revealed that patients with nonsense mutation have the poorest prognosis in comparison with wild-type cases and other types of mutations in this gene. Classification of TP53 mutations with respect to the degree of disturbance of protein structure showed association of disruptive mutations with poorer patients' outcome in contrast to wild-type and non-disruptive mutations. In conclusion, the present study confirms p53 as a potential predictive and prognostic factor in oncology practice and highlights the growing evidence that distinct types of mutations have different clinical impacts.
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Copy and paste a formatted citation
Spandidos Publications style
Dobes P, Podhorec J, Coufal O, Jureckova A, Petrakova K, Vojtesek B and Hrstka R: Influence of mutation type on prognostic and predictive values of TP53 status in primary breast cancer patients. Oncol Rep 32: 1695-1702, 2014.
APA
Dobes, P., Podhorec, J., Coufal, O., Jureckova, A., Petrakova, K., Vojtesek, B., & Hrstka, R. (2014). Influence of mutation type on prognostic and predictive values of TP53 status in primary breast cancer patients. Oncology Reports, 32, 1695-1702. https://doi.org/10.3892/or.2014.3346
MLA
Dobes, P., Podhorec, J., Coufal, O., Jureckova, A., Petrakova, K., Vojtesek, B., Hrstka, R."Influence of mutation type on prognostic and predictive values of TP53 status in primary breast cancer patients". Oncology Reports 32.4 (2014): 1695-1702.
Chicago
Dobes, P., Podhorec, J., Coufal, O., Jureckova, A., Petrakova, K., Vojtesek, B., Hrstka, R."Influence of mutation type on prognostic and predictive values of TP53 status in primary breast cancer patients". Oncology Reports 32, no. 4 (2014): 1695-1702. https://doi.org/10.3892/or.2014.3346
Copy and paste a formatted citation
x
Spandidos Publications style
Dobes P, Podhorec J, Coufal O, Jureckova A, Petrakova K, Vojtesek B and Hrstka R: Influence of mutation type on prognostic and predictive values of TP53 status in primary breast cancer patients. Oncol Rep 32: 1695-1702, 2014.
APA
Dobes, P., Podhorec, J., Coufal, O., Jureckova, A., Petrakova, K., Vojtesek, B., & Hrstka, R. (2014). Influence of mutation type on prognostic and predictive values of TP53 status in primary breast cancer patients. Oncology Reports, 32, 1695-1702. https://doi.org/10.3892/or.2014.3346
MLA
Dobes, P., Podhorec, J., Coufal, O., Jureckova, A., Petrakova, K., Vojtesek, B., Hrstka, R."Influence of mutation type on prognostic and predictive values of TP53 status in primary breast cancer patients". Oncology Reports 32.4 (2014): 1695-1702.
Chicago
Dobes, P., Podhorec, J., Coufal, O., Jureckova, A., Petrakova, K., Vojtesek, B., Hrstka, R."Influence of mutation type on prognostic and predictive values of TP53 status in primary breast cancer patients". Oncology Reports 32, no. 4 (2014): 1695-1702. https://doi.org/10.3892/or.2014.3346
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