Journal Articles

Review

Targeting forkhead box transcription factors FOXM1 and FOXO in leukemia (Review)

Hong Zhu

Pages: 1327-1334 Published online on: 23 July 2014
Article Open Access

Role of Lifeguard β-isoform in the development of breast cancer

Nadjib Dastagir, Andrea Lazaridis, Khaled Dastagir, Kerstin Reimers, Peter M. Vogt, Vesna Bucan

Pages: 1335-1340 Published online on: 25 July 2014
Article Open Access

Phloroglucinol induces apoptosis via apoptotic signaling pathways in HT-29 colon cancer cells

Mi-Hye Kang, In-Hye Kim, Taek-Jeong Nam

Pages: 1341-1346 Published online on: 23 July 2014
Article Open Access

TAGLN expression is upregulated in NF1-associated malignant peripheral nerve sheath tumors by hypomethylation in its promoter and subpromoter regions

Gun-Hoo Park, Su-Jin Lee, Hyunee Yim, Jae-Ho Han, Hyon J. Kim, Young-Bae  Sohn, Jung Min Ko, Seon-Yong Jeong

Pages: 1347-1354 Published online on: 04 August 2014
Article Open Access

Invasive micropapillary carcinoma of the extrahepatic bile duct and its malignant potential

Tadashi Yoshizawa, Yoshikazu Toyoki, Hideaki Hirai, Toshihiro  Haga, Takahito Toba, Shingo Sakuraba, Kensuke Okano, Yunyan Wu, Hiroko  Seino, Satoko Morohashi, Kenichi Hakamada, Hiroshi Kijima

Pages: 1355-1361 Published online on: 07 August 2014
Article Open Access

WWOX modulates the gene expression profile in the T98G glioblastoma cell line rendering its phenotype less malignant

Katarzyna Kośla, Magdalena Nowakowska, Karolina Pospiech, Andrzej K. Bednarek

Pages: 1362-1368 Published online on: 17 July 2014
Article Open Access

SphK1 confers resistance to apoptosis in gastric cancer cells by downregulating Bim via stimulating Akt/FoxO3a signaling

Huaping Xiong, Jicheng Wang, Hongyu Guan, Jueheng Wu, Ru Xu, Min Wang, Xia Rong, Ke Huang, Jieting Huang, Qiao Liao, Yongshui Fu, Jie Yuan

Pages: 1369-1373 Published online on: 07 August 2014
Article

A comprehensive search for microRNAs with expression profiles modulated by oncogenic KRAS: Potential involvement of miR-31 in lung carcinogenesis

Koji Okudela, Takeshisa Suzuki, Shigeaki  Umeda, Yoko  Tateishi, Hideaki  Mitsui, Yohei  Miyagi, Kenichi  Ohashi

Pages: 1374-1384 Published online on: 18 July 2014
Article

Mead acid inhibits the growth of KPL-1 human breast cancer cells in vitro and in vivo

Yuichi Kinoshita, Katsuhiko Yoshizawa, Kei Hamazaki, Yuko Emoto, Takashi Yuri, Michiko Yuki, Nobuaki Shikata, Hiroshi Kawashima, Airo Tsubura

Pages: 1385-1394 Published online on: 07 August 2014
Article

Inhibition of Rac1 activity induces G1/S phase arrest through the GSK3/cyclin D1 pathway in human cancer cells

Linna Liu, Hongmei Zhang, Lei Shi, Wenjuan Zhang, Juanli Yuan, Xiang Chen, Juanjuan Liu, Yan Zhang, Zhipeng Wang

Pages: 1395-1400 Published online on: 07 August 2014
Article

Induced IGF-1R activation contributes to gefitinib resistance following combined treatment with paclitaxel, cisplatin and gefitinib in A549 lung cancer cells

Xiaojun Ge, Qingjuan Chen, Yang Ping Wu, Yuchen  Zhang, Hongwei Xia, Dandan  Yuan, Qi  Chen, Weibing  Leng, Liang  Chen, Qiulin  Tang, Xiaohui  Pang, Feng Bi

Pages: 1401-1408 Published online on: 15 July 2014
Article

MicroRNA-100 promotes migration and invasion through mammalian target of rapamycin in esophageal squamous cell carcinoma

Naijian Zhang, Hailong Fu, Leilei Song, Youhong Ding, Xiufang Wang, Chao Zhao, Yiqi Zhao, Feng Jiao, Yaping Zhao

Pages: 1409-1418 Published online on: 07 August 2014
Article

KRAS and BRAF mutations and MSI status in precursor lesions of colorectal cancer detected by colonoscopy

L. S. Yamane, C. Scapulatempo-Neto, L. Alvarenga, C. Z. Oliveira, G. N. Berardinelli, E. Almodova, T. R. Cunha, G. Fava, W. Colaiacovo, A. Melani, J. H. Fregnani, R. M. Reis, D. P. Guimarães

Pages: 1419-1426 Published online on: 18 July 2014
Article

Differential protein expression and novel biomarkers related to 5-FU resistance in a 3D colorectal adenocarcinoma model

Sang-Hak Lee, Jae Kook Nam, Jong-Kook Park, Joo-Ho Lee, Do Sik Min, Hyo-Jeong Kuh

Pages: 1427-1434 Published online on: 18 July 2014
Article

Variability in the measurement of the methylation status of lung cancer-related genes in bronchial secretions

Laura Millares, Antoni Rosell, Laia Setó, José Sanz, Felipe Andreo, Eduard Monsó

Pages: 1435-1440 Published online on: 28 July 2014
Article
Article

Genetic analysis of an orbital metastasis from a primary hepatic neuroendocrine carcinoma

Jacob Ø. Rasmussen, Sarah L. von Holstein, Jan U. Prause, Ben Vainer, Alastair B. Hansen, André Fehr, Göran Stenman, Steffen Heegaard

Pages: 1447-1450 Published online on: 21 July 2014
Article

USP22 promotes epithelial-mesenchymal transition via the FAK pathway in pancreatic cancer cells

Zhen Ning, Aman Wang, Jinxiao Liang, Yunpeng  Xie, Jiwei Liu, Qiu Yan, Zhongyu Wang

Pages: 1451-1458 Published online on: 23 July 2014
Article

Notch-1 regulates proliferation and differentiation of human bladder cancer cell lines by inhibiting expression of Krüppel-like factor 4

Xing Ai, Zhuomin Jia, Shuanglin Liu, Jiajun Wang, Xu Zhang

Pages: 1459-1464 Published online on: 23 July 2014
Article

Activation of phosphatidylinositol 3-kinase/Akt signaling mediates sorafenib-induced invasion and metastasis in hepatocellular carcinoma

Haiyong Wang, Litao Xu, Xiaoyan Zhu, Peng Wang, Huiying Chi, Zhiqiang Meng

Pages: 1465-1472 Published online on: 23 July 2014
Article

4-Amino-2-trifluoromethyl-phenyl retinate inhibits the migration of BGC-823 human gastric cancer cells by downregulating the phosphorylation level of MLC II

Anla Hu, Yanyan Yang, Sumei Zhang, Qing Zhou, Wei Wei, Yuan Wang

Pages: 1473-1480 Published online on: 18 July 2014
Article

Paclitaxel-loaded trimethyl chitosan-based polymeric nanoparticle for the effective treatment of gastroenteric tumors

Rong-Feng Song, Xiao-Jun Li, Xiao-Liang Cheng, Ai-Rong  Fu, Yan-Hua Wang, Yan-Jun Feng, Yan Xiong

Pages: 1481-1488 Published online on: 21 July 2014
Article

Far from resolved: Stromal cell-based iTRAQ research of muscle-invasive bladder cancer regarding heterogeneity

Peng-Fei Liu, Yong-Hua Wang, Yan-Wei Cao, Hai-Ping Jiang, Xue-Cheng Yang, Xin-Sheng Wang, Hai-Tao Niu

Pages: 1489-1496 Published online on: 18 July 2014
Article

Knockdown of galectin-1 suppresses the growth and invasion of osteosarcoma cells through inhibition of the MAPK/ERK pathway

Jin-Hao Miao, Shu-Qiang Wang, Ming-Hui  Zhang, Feng‑Bin  Yu, Lei  Zhang, Zhong-Xiang Yu, Yong Kuang

Pages: 1497-1504 Published online on: 24 July 2014
Article

RASSF5 inhibits growth and invasion and induces apoptosis in osteosarcoma cells through activation of MST1/LATS1 signaling

Xu-Hui Zhou, Chao-Qun Yang, Cheng-Lin  Zhang, Yang Gao, Hong-Bin  Yuan, Ce Wang

Pages: 1505-1512 Published online on: 07 August 2014
Article

Downregulation of phosphoglycerate kinase 1 by shRNA sensitizes U251 xenografts to radiotherapy

Yi-Jun Cheng, Hao Ding, Hua-Qing Du, Hua  Yan, Jin-Bing Zhao, Wen-Bin Zhang, Yuan-Jie Zou, Hong-Yi  Liu, Hong Xiao

Pages: 1513-1520 Published online on: 23 July 2014
Article

Prostaglandin E2 promotes the cell growth and invasive ability of hepatocellular carcinoma cells by upregulating c-Myc expression via EP4 receptor and the PKA signaling pathway

Shukai Xia, Juan Ma, Xiaoming Bai, Hai Zhang, Shanyu  Cheng, Min Zhang, Li Zhang, Mingzhan Du, Yipin  Wang, Hai Li, Rong Rong, Feng Shi, Qinyi Yang, Jing Leng

Pages: 1521-1530 Published online on: 07 August 2014
Article

Broussonetia kazinoki modulates the expression of VEGFR-2 and MMP-2 through the inhibition of ERK, Akt and p70S6K‑dependent signaling pathways: Its implication in endothelial cell proliferation, migration and tubular formation

Young-Rak Cho, Jae Hyeon Kim, Jin-Kyu Kim, Eun-Kyung Ahn, Hye-Jin Ko, Jae Kyung In, Sang-Jin Lee, Gyu-Un Bae, Yong Kee Kim, Joa Sub Oh, Dong-Wan Seo

Pages: 1531-1536 Published online on: 04 August 2014
Article

NRP-1 expression is strongly associated with the progression of pituitary adenomas

Sang Won Lee, Jung Eun Lee, Chang Young Yoo, Myoung Seok Ko, Chan Soon Park, Seung-Ho Yang

Pages: 1537-1542 Published online on: 07 August 2014
Article

Effects of lentivirus-mediated RNAi knockdown of NEDD9 on human lung adenocarcinoma cells in vitro and in vivo

Jing-Xia Chang, Feng Gao, Guo-Qiang Zhao, Guo-Jun Zhang

Pages: 1543-1549 Published online on: 22 July 2014
Article

Serum anti-osteopontin autoantibody as a novel diagnostic and prognostic biomarker in patients with hepatocellular carcinoma

Xia Ying, Yue Zhao, Jun-Lan Wang, Xia Zhou, Jing Zhao, Chen-Chen He, Xi-Jing Guo, Gui-Hua Jin, Li-Juan Wang, Qing Zhu, Su-Xia Han

Pages: 1550-1556 Published online on: 30 July 2014
Article

Arsenic trioxide induces autophagy and antitumor effects in Burkitt's lymphoma Raji cells

Cai-Li Li, Hu-Lai Wei, Jing Chen, Bei Wang, Bei Xie, Lin-Lan Fan, Lin-Jing Li

Pages: 1557-1563 Published online on: 30 July 2014
Article

AQP5: A novel biomarker that predicts poor clinical outcome in colorectal cancer

Tao Shan, Xijuan Cui, Wei Li, Wanrun Lin, Yiming Li

Pages: 1564-1570 Published online on: 04 August 2014
Article

Prognostic significance of miR-218 in human hepatocellular carcinoma and its role in cell growth

Kangsheng Tu, Chao Li, Xin Zheng, Wei Yang, Yingmin Yao, Qingguang Liu

Pages: 1571-1577 Published online on: 07 August 2014
Article

Knockdown of ubiquitin associated protein 2-like inhibits the growth and migration of prostate cancer cells

Dong Li, Yiran Huang

Pages: 1578-1584 Published online on: 25 July 2014
Article

Isoalantolactone inhibits constitutive NF-κB activation and induces reactive oxygen species-mediated apoptosis in osteosarcoma U2OS cells through mitochondrial dysfunction

Weihua Di, Muhammad Khan, Azhar Rasul, Meiyan Sun, Yujie Sui, Lili  Zhong, Longfei Yang, Qi Zhu, Liangtao Feng, Tonghui Ma

Pages: 1585-1593 Published online on: 30 July 2014
Article

YAP is overexpressed in clear cell renal cell carcinoma and its knockdown reduces cell proliferation and induces cell cycle arrest and apoptosis

Jian-Jia Cao, Xiu-Min Zhao, De-Lin  Wang, Ke-Hong  Chen, Xia  Sheng, Wen-Bin  Li, Mei-Cai  Li, Wu-Jiang  Liu, Jiang He

Pages: 1594-1600 Published online on: 22 July 2014
Article

Assessment of insulin-like growth factor 1 receptor as an oncogene in esophageal squamous cell carcinoma and its potential implication in chemotherapy

Wang Ma, Tengfei Zhang, Jian Pan, Ni Shi, Qingxia Fan, Liuxing Wang, Shih Hsin Lu

Pages: 1601-1609 Published online on: 22 July 2014
Article

Curcumin sensitizes glioblastoma to temozolomide by simultaneously generating ROS and disrupting AKT/mTOR signaling

Haitao Yin, Yun Zhou, Cuixia Wen, Chong Zhou, Wei Zhang, Xiang Hu, Lifeng Wang, Chuanwen You, Junfei Shao

Pages: 1610-1616 Published online on: 18 July 2014
Article

Hedgehog pathway inhibitor-4 suppresses malignant properties of chondrosarcoma cells by disturbing tumor ciliogenesis

Wei Xiang, Ting Jiang, Fengjing Guo, Chen Gong, Kaixiang Yang, Yingxing Wu, Xin Huang, Weiting Cheng, Kai Xu

Pages: 1622-1630 Published online on: 31 July 2014
Article

KPNA2 is a promising biomarker candidate for esophageal squamous cell carcinoma and correlates with cell proliferation

Shouzhi Ma, Xiaohang Zhao

Pages: 1631-1637 Published online on: 04 August 2014
Article

High ALDHdim-expressing CD34+CD38- cells in leukapheresed peripheral blood is a reliable guide for a successful leukemic xenograft model of acute myeloid leukemia

Ji Yoon Lee, Sohye Park, A-Reum Han, Jihyang Lim, Woo-Sung Min, Hee-Je Kim

Pages: 1638-1646 Published online on: 24 July 2014
Article

Synergistic cytotoxic effect of genistein and doxorubicin on drug-resistant human breast cancer MCF-7/Adr cells

Jia-Peng Xue, Geng Wang, Zong-Bin Zhao, Qun Wang, Yun Shi

Pages: 1647-1653 Published online on: 29 July 2014
Article

Contrast-enhanced color Doppler ultrasonography increases diagnostic accuracy for soft tissue tumors

Naoto Oebisu, Manabu Hoshi, Makoto Ieguchi, Jun  Takada, Tadashi Iwai, Masahiko Ohsawa, Hiroaki Nakamura

Pages: 1654-1660 Published online on: 04 August 2014
Article

Hotspot mutations in common oncogenes are infrequent in nasopharyngeal carcinoma

Ning Jiang, Na Liu, Fan Yang, Qiming Zhou, Ruixue Cui, Wei Jiang, Qingmei  He, Wenfei Li, Ying Guo, Jing Zeng, Jingping Yun, Xinchun Chen, Boping Zhou, Ying Sun, Huiyun Wang, Zhuo G. Chen, Jun Ma

Pages: 1661-1669 Published online on: 01 August 2014
Article

Identification of aspirin analogues that repress NF-κB signalling and demonstrate anti-proliferative activity towards colorectal cancer in vitro and in vivo

Ann-Katrin Claudius, Chandra S. Kankipati, Rajagopal S. Kilari, Sadiya Hassan, Kerry Guest, Steven T. Russell, Chris J. Perry, Lesley A. Stark, Iain D. Nicholl

Pages: 1670-1680 Published online on: 31 July 2014
Article

Combined cetuximab and celecoxib treatment exhibits a synergistic anticancer effect on human oral squamous cell carcinoma in vitro and in vivo

Ming Qian, Donghua Qian, Hongyu Jing, Yang Li, Chengyuan Ma, Yanmin Zhou

Pages: 1681-1688 Published online on: 16 July 2014
Article

CIP2A regulates cell proliferation via the AKT signaling pathway in human lung cancer

Ningjing Lei, Bo Peng, Jian-Ying Zhang

Pages: 1689-1694 Published online on: 01 August 2014
Article

Influence of mutation type on prognostic and predictive values of TP53 status in primary breast cancer patients

Petr Dobes, Jan Podhorec, Oldrich  Coufal, Andrea  Jureckova, Katarina  Petrakova, Borivoj  Vojtesek, Roman Hrstka

Pages: 1695-1702 Published online on: 21 July 2014
Article

Effect of nitric oxide synthase on multiple drug resistance is related to Wnt signaling in non-small cell lung cancer

Yang Li, Chengyuan Ma, Xu Shi, Zhongmei Wen, Dan Li, Munan Sun, Hui Ding

Pages: 1703-1708 Published online on: 23 July 2014
Article

Bradykinin stimulates IL-6 production and cell invasion in colorectal cancer cells

Guojun Wang, Yanwei Ye, Xiefu Zhang, Junmin Song

Pages: 1709-1714 Published online on: 30 July 2014
Article

Cancer cells release anaphylatoxin C5a from C5 by serine protease to enhance invasiveness

Hidetoshi Nitta, Yoji  Murakami, Yoshihiro  Wada, Masatoshi  Eto, Hideo  Baba, Takahisa  Imamura

Pages: 1715-1719 Published online on: 18 July 2014
Article

MicroRNA-145 is a potential prognostic factor of scirrhous type gastric cancer

Yutaka Naito, Kyohei Yasuno, Hiroko Tagawa, Naoya  Sakamoto, Naohide  Oue, Masakazu  Yashiro, Kazuhiro  Sentani, Keisuke  Goto, Shunsuke  Shinmei, Htoo  Zarni Oo, Kazuyoshi Yanagihara, Kosei Hirakawa, Wataru Yasui

Pages: 1720-1726 Published online on: 16 July 2014
Article

Cholesterol synthesis inhibitor RO 48-8071 suppresses transcriptional activity of human estrogen and androgen receptor

Benford Mafuvadze, Yayun Liang, Salman M. Hyder

Pages: 1727-1733 Published online on: 15 July 2014
Article

MicroRNA-183 is involved in cell proliferation, survival and poor prognosis in pancreatic ductal adenocarcinoma by regulating Bmi-1

Liang Zhou, Wei-Guo Zhang, De-Sheng  Wang, Kai‑Shan  Tao, Wen-Jie Song, Ke-Feng  Dou

Pages: 1734-1740 Published online on: 01 August 2014
Article

Effect of the PTEN gene on adhesion, invasion and metastasis of osteosarcoma cells

Yong Hu, Shenglin Xu, Wensen Jin, Qiyi Yi, Wei  Wei

Pages: 1741-1747 Published online on: 25 July 2014
Article

Diallyl disulfide induces G2/M arrest and promotes apoptosis through the p53/p21 and MEK-ERK pathways in human esophageal squamous cell carcinoma

Xiaoran Yin, Rong Zhang, Cheng Feng, Jun Zhang, Dong Liu, Kun Xu, Xijing Wang, Shuqun Zhang, Zongfang Li, Xinlian Liu, Hongbing Ma

Pages: 1748-1756 Published online on: 25 July 2014
Journal Cover

October 2014
Volume 32 Issue 4

Print ISSN: 1021-335X
Online ISSN: 1791-2431

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