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Article

Contrast-enhanced color Doppler ultrasonography increases diagnostic accuracy for soft tissue tumors

  • Authors:
    • Naoto Oebisu
    • Manabu Hoshi
    • Makoto Ieguchi
    • Jun  Takada
    • Tadashi Iwai
    • Masahiko Ohsawa
    • Hiroaki Nakamura
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Abeno-Ku, Osaka 545‑8585, Japan, Department of Diagnostic Pathology, Osaka City University Graduate School of Medicine, Abeno-Ku, Osaka 545‑8585, Japan
  • Pages: 1654-1660
    |
    Published online on: August 4, 2014
       https://doi.org/10.3892/or.2014.3378
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Abstract

Resolution of ultrasonography (US) has undergone marked development. Additionally, a new-generation contrast medium (Sonazoid) used for US is newly available. Contrast-enhanced US has been widely used for evaluating several types of cancer. In the present study, we evaluated the ability of color Doppler US (CDUS) and Sonazoid to differentiate between benign and malignant soft tissue tumors. A total of 180 patients (87 male, 93 female) were enrolled in the present study. The patient ages ranged from 1 to 91 years (mean 58.1±20.0 years). The maximum size, depth, tumor margins, shape, echogenicity and textural pattern were measured on gray-scale images. CDUS was used to evaluate the intratumoral blood flow with and without Sonazoid. Peak systolic flow velocity (Vp), mean flow velocity (Vm), resistivity index (RI) and pulsatility index (PI) of each detected intratumoral artery were automatically calculated with power Doppler US (PDUS). The present study included 118 benign and 62 malignant tumors. Statistical significances were found in size, depth, tumor margin and textural pattern but not in shape or echogenicity on gray-scale images. Before Sonazoid injection, CDUS findings showed 55% sensitivity, 77% specificity and 69% accuracy, whereas contrast-enhanced CDUS showed 87% sensitivity, 68% specificity and 74% accuracy. There were no statistically significant differences between malignant and benign tumors regarding the mean Vp, Vm, RI and PI values determined on PDUS. In conclusion, contrast-enhanced CDUS proved to be a reliable diagnostic tool for detecting malignant potential in soft tissue tumors.
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Copy and paste a formatted citation
Spandidos Publications style
Oebisu N, Hoshi M, Ieguchi M, Takada J, Iwai T, Ohsawa M and Nakamura H: Contrast-enhanced color Doppler ultrasonography increases diagnostic accuracy for soft tissue tumors. Oncol Rep 32: 1654-1660, 2014.
APA
Oebisu, N., Hoshi, M., Ieguchi, M., Takada, J., Iwai, T., Ohsawa, M., & Nakamura, H. (2014). Contrast-enhanced color Doppler ultrasonography increases diagnostic accuracy for soft tissue tumors. Oncology Reports, 32, 1654-1660. https://doi.org/10.3892/or.2014.3378
MLA
Oebisu, N., Hoshi, M., Ieguchi, M., Takada, J., Iwai, T., Ohsawa, M., Nakamura, H."Contrast-enhanced color Doppler ultrasonography increases diagnostic accuracy for soft tissue tumors". Oncology Reports 32.4 (2014): 1654-1660.
Chicago
Oebisu, N., Hoshi, M., Ieguchi, M., Takada, J., Iwai, T., Ohsawa, M., Nakamura, H."Contrast-enhanced color Doppler ultrasonography increases diagnostic accuracy for soft tissue tumors". Oncology Reports 32, no. 4 (2014): 1654-1660. https://doi.org/10.3892/or.2014.3378
Copy and paste a formatted citation
x
Spandidos Publications style
Oebisu N, Hoshi M, Ieguchi M, Takada J, Iwai T, Ohsawa M and Nakamura H: Contrast-enhanced color Doppler ultrasonography increases diagnostic accuracy for soft tissue tumors. Oncol Rep 32: 1654-1660, 2014.
APA
Oebisu, N., Hoshi, M., Ieguchi, M., Takada, J., Iwai, T., Ohsawa, M., & Nakamura, H. (2014). Contrast-enhanced color Doppler ultrasonography increases diagnostic accuracy for soft tissue tumors. Oncology Reports, 32, 1654-1660. https://doi.org/10.3892/or.2014.3378
MLA
Oebisu, N., Hoshi, M., Ieguchi, M., Takada, J., Iwai, T., Ohsawa, M., Nakamura, H."Contrast-enhanced color Doppler ultrasonography increases diagnostic accuracy for soft tissue tumors". Oncology Reports 32.4 (2014): 1654-1660.
Chicago
Oebisu, N., Hoshi, M., Ieguchi, M., Takada, J., Iwai, T., Ohsawa, M., Nakamura, H."Contrast-enhanced color Doppler ultrasonography increases diagnostic accuracy for soft tissue tumors". Oncology Reports 32, no. 4 (2014): 1654-1660. https://doi.org/10.3892/or.2014.3378
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