Upregulation of GRIM-19 suppresses the growth of oral squamous cell carcinoma in vitro and in vivo

  • Authors:
    • Minghe Li
    • Zhihong Li
    • Chongyang Liang
    • Chengmin Han
    • Wei Huang
    • Fei Sun
  • View Affiliations

  • Published online on: August 20, 2014     https://doi.org/10.3892/or.2014.3423
  • Pages: 2183-2190
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Abstract

Constitutive activation of the signal transducer and activator of transcription 3 (STAT3) and its upregulation contribute to the progression and metastasis of several different tumor types. The gene associated with retinoid‑interferon‑induced mortality-19 (GRIM-19) is known to functionally interact with STAT3 and inhibit its transcriptional activity. It has been reported that upregulation of genes associated with GRIM-19 can significantly reduce the tumor growth of several types of tumors. However, little is known in regards to its role in oral squamous cell carcinoma (OSCC). In the present study, a recombinant eukaryotic expression plasmid carrying GRIM-19 was constructed to evaluate its effects on OSCC cancer growth. Upregulation of GRIM-19 in OSCC cells significantly inhibited cell proliferation, migration and invasion in vitro and suppressed tumor growth in vivo. Moreover, we found that upregulation of GRIM-19 reduced cyclin D1, Bcl-2, vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) expression whose protein is involved in STAT3 activation. Taken together, these findings suggest that GRIM-19 plays an inhibitory role in the progression of OSCC, and contribute to the future development of STAT3-based gene therapeutic approaches for OSCC.
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November-2014
Volume 32 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Li M, Li Z, Liang C, Han C, Huang W and Sun F: Upregulation of GRIM-19 suppresses the growth of oral squamous cell carcinoma in vitro and in vivo. Oncol Rep 32: 2183-2190, 2014
APA
Li, M., Li, Z., Liang, C., Han, C., Huang, W., & Sun, F. (2014). Upregulation of GRIM-19 suppresses the growth of oral squamous cell carcinoma in vitro and in vivo. Oncology Reports, 32, 2183-2190. https://doi.org/10.3892/or.2014.3423
MLA
Li, M., Li, Z., Liang, C., Han, C., Huang, W., Sun, F."Upregulation of GRIM-19 suppresses the growth of oral squamous cell carcinoma in vitro and in vivo". Oncology Reports 32.5 (2014): 2183-2190.
Chicago
Li, M., Li, Z., Liang, C., Han, C., Huang, W., Sun, F."Upregulation of GRIM-19 suppresses the growth of oral squamous cell carcinoma in vitro and in vivo". Oncology Reports 32, no. 5 (2014): 2183-2190. https://doi.org/10.3892/or.2014.3423