The role of APOBEC3B in chondrosarcoma

  • Authors:
    • Zhe Jin
    • Ya-Xin Han
    • Xiao-Rui Han
  • View Affiliations

  • Published online on: August 22, 2014     https://doi.org/10.3892/or.2014.3437
  • Pages: 1867-1872
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Chondrosarcomas rank as the third most common type of bone tumors. In the present study, we demonstrated that expression of the apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3B (APOBEC3B) was higher in cancer tissues when compared to that in normal tissues. In order to further investigate the effects of APOBEC3B expression, we knocked down APOBEC3B expression in chondrosarcoma cells. We found that the percentage of apoptotic cells was higher in the APOBEC3B-knockdown cells than the percentage in the untransfected cells. Furthermore, we found that the reduced antitumor activity of RUNX3 was caused by APOBEC3B. Finally, we demonstrated that caspase-3, -8 and -9 activity was significantly increased in the RUNX3-expressing cells with APOBEC3B knockdown. In summary, our results indicate that APOBEC3B knockdown may be a useful therapy to enhance apoptosis in chondrosarcoma.
View Figures
View References

Related Articles

Journal Cover

November-2014
Volume 32 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Jin Z, Han Y and Han X: The role of APOBEC3B in chondrosarcoma. Oncol Rep 32: 1867-1872, 2014.
APA
Jin, Z., Han, Y., & Han, X. (2014). The role of APOBEC3B in chondrosarcoma. Oncology Reports, 32, 1867-1872. https://doi.org/10.3892/or.2014.3437
MLA
Jin, Z., Han, Y., Han, X."The role of APOBEC3B in chondrosarcoma". Oncology Reports 32.5 (2014): 1867-1872.
Chicago
Jin, Z., Han, Y., Han, X."The role of APOBEC3B in chondrosarcoma". Oncology Reports 32, no. 5 (2014): 1867-1872. https://doi.org/10.3892/or.2014.3437