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November-2014 Volume 32 Issue 5

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Article

The role of APOBEC3B in chondrosarcoma

  • Authors:
    • Zhe Jin
    • Ya-Xin Han
    • Xiao-Rui Han
  • View Affiliations / Copyright

    Affiliations: Department of Joint Surgery and Sports Medicine, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
  • Pages: 1867-1872
    |
    Published online on: August 22, 2014
       https://doi.org/10.3892/or.2014.3437
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Abstract

Chondrosarcomas rank as the third most common type of bone tumors. In the present study, we demonstrated that expression of the apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3B (APOBEC3B) was higher in cancer tissues when compared to that in normal tissues. In order to further investigate the effects of APOBEC3B expression, we knocked down APOBEC3B expression in chondrosarcoma cells. We found that the percentage of apoptotic cells was higher in the APOBEC3B-knockdown cells than the percentage in the untransfected cells. Furthermore, we found that the reduced antitumor activity of RUNX3 was caused by APOBEC3B. Finally, we demonstrated that caspase-3, -8 and -9 activity was significantly increased in the RUNX3-expressing cells with APOBEC3B knockdown. In summary, our results indicate that APOBEC3B knockdown may be a useful therapy to enhance apoptosis in chondrosarcoma.
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Copy and paste a formatted citation
Spandidos Publications style
Jin Z, Han Y and Han X: The role of APOBEC3B in chondrosarcoma. Oncol Rep 32: 1867-1872, 2014.
APA
Jin, Z., Han, Y., & Han, X. (2014). The role of APOBEC3B in chondrosarcoma. Oncology Reports, 32, 1867-1872. https://doi.org/10.3892/or.2014.3437
MLA
Jin, Z., Han, Y., Han, X."The role of APOBEC3B in chondrosarcoma". Oncology Reports 32.5 (2014): 1867-1872.
Chicago
Jin, Z., Han, Y., Han, X."The role of APOBEC3B in chondrosarcoma". Oncology Reports 32, no. 5 (2014): 1867-1872. https://doi.org/10.3892/or.2014.3437
Copy and paste a formatted citation
x
Spandidos Publications style
Jin Z, Han Y and Han X: The role of APOBEC3B in chondrosarcoma. Oncol Rep 32: 1867-1872, 2014.
APA
Jin, Z., Han, Y., & Han, X. (2014). The role of APOBEC3B in chondrosarcoma. Oncology Reports, 32, 1867-1872. https://doi.org/10.3892/or.2014.3437
MLA
Jin, Z., Han, Y., Han, X."The role of APOBEC3B in chondrosarcoma". Oncology Reports 32.5 (2014): 1867-1872.
Chicago
Jin, Z., Han, Y., Han, X."The role of APOBEC3B in chondrosarcoma". Oncology Reports 32, no. 5 (2014): 1867-1872. https://doi.org/10.3892/or.2014.3437
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