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November-2014 Volume 32 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

Upregulation of Limk1 caused by microRNA-138 loss aggravates the metastasis of ovarian cancer by activation of Limk1/cofilin signaling

  • Authors:
    • Puxiang Chen
    • Mengjun Zeng
    • Yan Zhao
    • Xiaolin Fang
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, the Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China
  • Pages: 2070-2076
    |
    Published online on: September 2, 2014
       https://doi.org/10.3892/or.2014.3461
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Abstract

LIM kinase 1 (Limk1) is associated with cell prolife­ration and metastasis and its dysregulated expression has been observed in many types of cancer. The present study aimed to examine the role of Limk1 in the development of ovarian cancer, as well as the underlying molecular mechanism involved. The results showed that increased Limk1 and decreased miR-138 expression co-existed in ovarian cancer. Furthermore, knockout of Limk1 or the overexpression of miR-138 resulted in reduced cell invasion and migration, while silencing of miR-138 led to enhancement of the invasion and migration of ovarian cancer cells. Cell growth was inhibited by the overexpression of miR-138, although not by the knockout of Limk1. miR-138 directly targeted Limk1 and inhibited ovarian cancer cell growth by PCNA and Bcl-2. Moreover, Limk1/cofilin/p-cofilin is likely a critical signaling pathway involving in miR-138 modulation of ovarian cancer cell metastasis. The results provide evidence supporting miR-138/Limk1 as a novel diagnostic or therapeutic target for ovarian cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Chen P, Zeng M, Zhao Y and Fang X: Upregulation of Limk1 caused by microRNA-138 loss aggravates the metastasis of ovarian cancer by activation of Limk1/cofilin signaling. Oncol Rep 32: 2070-2076, 2014.
APA
Chen, P., Zeng, M., Zhao, Y., & Fang, X. (2014). Upregulation of Limk1 caused by microRNA-138 loss aggravates the metastasis of ovarian cancer by activation of Limk1/cofilin signaling. Oncology Reports, 32, 2070-2076. https://doi.org/10.3892/or.2014.3461
MLA
Chen, P., Zeng, M., Zhao, Y., Fang, X."Upregulation of Limk1 caused by microRNA-138 loss aggravates the metastasis of ovarian cancer by activation of Limk1/cofilin signaling". Oncology Reports 32.5 (2014): 2070-2076.
Chicago
Chen, P., Zeng, M., Zhao, Y., Fang, X."Upregulation of Limk1 caused by microRNA-138 loss aggravates the metastasis of ovarian cancer by activation of Limk1/cofilin signaling". Oncology Reports 32, no. 5 (2014): 2070-2076. https://doi.org/10.3892/or.2014.3461
Copy and paste a formatted citation
x
Spandidos Publications style
Chen P, Zeng M, Zhao Y and Fang X: Upregulation of Limk1 caused by microRNA-138 loss aggravates the metastasis of ovarian cancer by activation of Limk1/cofilin signaling. Oncol Rep 32: 2070-2076, 2014.
APA
Chen, P., Zeng, M., Zhao, Y., & Fang, X. (2014). Upregulation of Limk1 caused by microRNA-138 loss aggravates the metastasis of ovarian cancer by activation of Limk1/cofilin signaling. Oncology Reports, 32, 2070-2076. https://doi.org/10.3892/or.2014.3461
MLA
Chen, P., Zeng, M., Zhao, Y., Fang, X."Upregulation of Limk1 caused by microRNA-138 loss aggravates the metastasis of ovarian cancer by activation of Limk1/cofilin signaling". Oncology Reports 32.5 (2014): 2070-2076.
Chicago
Chen, P., Zeng, M., Zhao, Y., Fang, X."Upregulation of Limk1 caused by microRNA-138 loss aggravates the metastasis of ovarian cancer by activation of Limk1/cofilin signaling". Oncology Reports 32, no. 5 (2014): 2070-2076. https://doi.org/10.3892/or.2014.3461
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