Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
November-2014 Volume 32 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2014 Volume 32 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model

  • Authors:
    • Carlos Alberto Valencia Antúnez
    • Lucía Taja Chayeb
    • Miguel Ángel Rodríguez-Segura
    • Guadalupe Soledad López Álvarez
    • Claudia M. García-Cuéllar
    • Saúl Villa Treviño
  • View Affiliations / Copyright

    Affiliations: Department of Cell Biology Center for Research and Advanced Studies (CINVESTAV) IPN, Basic Research Branch, Mexico, D.F., Mexico, National Cancer Institute, Basic Research Branch, Mexico, D.F., Mexico, Department of Physics, Center for Research and Advanced Studies (CINVESTAV) IPN, Basic Research Branch, Mexico, D.F., Mexico
  • Pages: 2093-2103
    |
    Published online on: September 3, 2014
       https://doi.org/10.3892/or.2014.3462
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Carcinogenesis is driven by the accumulation of mutations and abnormal DNA methylation patterns, particularly the hypermethylation of tumor‑suppressor genes. Changes in genomic DNA methylation patterns are established by the DNA methyltransferases (DNMTs) family: DNMT1, DNMT3a and DNMT3b. The DNMTs are known to be overexpressed in tumors. However, when the DNMTs expression profile is altered in earlier stages of carcinogenesis remains to be elucidated. The resistant hepatocyte model (RHM) allows the analysis of the hepatocellular carcinoma (HCC) from the formation of altered cell foci to the appearance of tumors in rats. To investigate the DNMTs expression in this model, we first observed that timp3, rassf1a and p16 genes became methylated during cancer development by methylation‑specific PCR (MSP) and the bisulphate sequencing PCR (BSP) of timp3. The differential expression at the RNA and protein level of the three DNMTs was also assessed. dnmt1 expression was higher in tumors than in normal and early cancer stages. However, no evident overexpression of the enzyme was identified by immunohistochemistry. By contrast, DNMT3a and DNMT3b were consistently subexpressed in tumors. In the present study, we report a carcinogenesis model that does not feature the overexpression of DNMT1 but exhibits a transient expression of DNMT3a and DNMT3b.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Aryee MJ, Liu W, Engelmann JC, Nuhn P, Gurel M, Haffner MC, Esopi D, Irizarry RA, Getzenberg RH, Nelson WG, Luo J, Xu J, Isaacs WB, Bova GS and Yegnasubramanian S: DNA methylation alterations exhibit intra-individual stability and inter-individual heterogeneity in prostate cancer metastases. Sci Transl Med. View Article : Google Scholar : 2013.

2 

Jones PA and Baylin SB: The fundamental role of epigenetic events in cancer. Nat Rev Genet. 3:85–93. 2002.

3 

Jones PA and Baylin SB: The epigenomics of cancer. Cell. 128:683–692. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Rishi V, Bhattacharya P, Chatterjee R, Rozenberg J, Zhao J, Glass K, Fitzgerald P and Vinson C: CpG methylation of half-CRE sequences creates C/EBPα binding sites that activate some tissue-specific genes. Proc Natl Acad Sci. 107:20311–20316. 2010.PubMed/NCBI

5 

Ziller MJ, Gu H, Müller F, Donaghey J, Tsai LT, Kohlbacher O, De Jager PL, Rosen ED, Bennett DA, Bernstein BE, Gnirke A and Meissner A: Charting a dynamic DNA methylation landscape of the human genome. Nature. 500:477–481. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Cheng X and Blumenthal RM: Mammalian DNA methyltransferases: a structural perspective. Structure. 3:341–350. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Sigalotti L, Fratta E, Coral S, Cortini E, Covre A, Nicolay HJ, Anzalone L, Pezzani L, Di Giacomo A, Fonsatti E, Colizzi F, Altomonte M, Calabrò L and Maio M: Epigenetic drugs as pleiotropic agents in cancer treatment: biomolecular aspects and clinical applications. J Cell Physiol. 212:330–344. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Asada K, Asada R, Yoshiji H, Fukui H, Floyd RA and Kotake Y: DNA cytosine methylation profile in various cancer-related genes is altered in cultured rat hepatocyte cell lines as compared with primary hepatocytes. Oncol Rep. 15:1241–1248. 2006.

9 

Feinberg AP and Vogelstein B: Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature. 301:89–92. 1983. View Article : Google Scholar : PubMed/NCBI

10 

Lee B and Muller MT: SUMOylation enhances DNA methyltransferase 1 activity. Biochem J. 421:449–461. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Ling Y, Sankpal UT, Robertson AK, McNally JG, Karpova T and Robertson KD: Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription. Nucleic Acids Res. 32:598–610. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Kanai Y and Hiroshida S: Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state. Carcinogenesis. 28:2434–2442. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Oh BK, Kim H, Park HJ, Shim YH, Choi J, Park C and Park YN: DNA methyltransferase expression and DNA methylation in human hepatocellular carcinoma and their clinicopathological correlation. Int J Mol Med. 20:65–73. 2007.PubMed/NCBI

14 

Choi MS, Shim YH, Hwa JY, Lee SK, Ro JY, Kim JS and Yu E: Expression of DNA methyltransferases in multistep hepatocarcinogenesis. Hum Pathol. 34:11–18. 2013. View Article : Google Scholar

15 

Yoshimasa S, Yae K, Tohru N, Michiie S, Hidetsugu S, Hiromasa I and Setsuo H: Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. Int J Cancer. 105:527–532. 2003. View Article : Google Scholar

16 

Raddatz G, Gao Q, Bender S, Jaenisch R and Lyko F: Dnmt3a protects active chromosome domains against cancer-associated hypomethylation. PLoS Genet. 8:e10031462012. View Article : Google Scholar : PubMed/NCBI

17 

Yan XJ, Xu J, Gu ZH, Pan CM, Lu G, Shen Y, Shi JY, Zhu YM, Tang L, Zhang XW, Liang WX, Mi JQ, Song HD, Li KQ, Chen Z and Chen SJ: Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet. 43:309–315. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Hlady RA, Novakova S, Opavska J, Klinkebiel D, Peters LS, Bies J, Hannah J, Iqbal J, Anderson KM, Siebler HM, Smith LM, Greiner TC, Bastola D, Joshi S, Lockridge O, Simpson MA, Felsher DW, Wagner KU, Chan WC, Christman JK and Opavsky R: Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis. J Clin Invest. 122:163–177. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Trinh BN, Long TI, Nickel AE, Shibata D and Laird PW: DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair. Mol Cell Biol. 22:2906–2917. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Pérez-Carreón JI, López-García C, Fattel-Fazenda S, Arce-Popoca E, Alemán-Lazarini L, Hernández-García S, Le Berrey V, Sokoly S, Francoisy JM and Villa-Treviño S: Gene expression profile related to the progresión of preneoplastic nodules toward hepatocellular carcinoma in rats. Neoplasia. 8:373–383. 2006.

21 

Rotstein J, Macdonald PD, Rabes HM and Farber E: Cell cycle kinetics of rat hepatocytes in early putative preneoplastic lesions in hepatocarcinogenesis. Cancer Res. 44:2913–2917. 1984.PubMed/NCBI

22 

Sánchez-Pérez Y, Carrasco-Legleu C, García-Cuellar C, Pérez-Carreón JI, Hernández-García S, Salcido-Neyoy M, Alemán-Lazarini L and Villa-Treviño S: Oxidative stress in carcinogenesis. Correlation between lipid peroxidation and induction of preneoplastic lesions in rat hepatocarcinogenesis. Cancer Lett. 217:25–32. 2005.PubMed/NCBI

23 

Solt D and Farber E: New principle for the analysis of chemical carcinogenesis. Nature. 263:701–703. 1976. View Article : Google Scholar

24 

Solt DB, Medine A and Farber E: Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis. Am J Pathol. 88:595–618. 1977.PubMed/NCBI

25 

Solt DB, Cayama E, Tsuda H, Enomoto K, Lee G and Farber E: Promotion of liver cancer development by brief exposure to dietary 2-acetylaminofluorene plus partial hepatectomy or carbon tetrachloride. Cancer Res. 43:188–191. 1983.PubMed/NCBI

26 

Pascale RM, Simile MM, De Miglio MR, Muroni MR, Calvisi DF, Asara G, Casabona D, Frau M, Seddaiu MA and Feo F: Cell cycle deregulation in liver lesions of rats with and without genetic predisposition to hepatocarcinogenesis. Hepatology. 35:1341–1350. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Wen BL, Ao L, Zhou ZY, Cui ZH, Zhou YH, Yuan XY, Xiang YL, Cao J and Liu JY: CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. Biochem Biophys Res Commun. 402:507–514. 2010. View Article : Google Scholar

28 

Agathanggelou A, Cooper WN and Latif F: Role of the Ras-association domain family 1 tumor suppressor gene in human cancers. Cancer Res. 65:3497–3508. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Du YP, Peng JS, Sun A, Tang ZH, Ling WH and Zhu HL: Assessment of the effect of betaine on p16 and c-myc DNA methylation and mRNA expression in a chemical induced rat liver cancer model. BMC Cancer. View Article : Google Scholar : 2009.

30 

Li J, Knobloch TJ, Poi MJ, Zhang Z, Davis AT, Muscarella P and Weghorst CM: Genetic alterations of RDINK4/ARF enhancer in human cancer cells. Mol Carcinog. 53:211–218. 2014.

31 

Gutierrez-Reyes G, del Carmen Garcia de Leon M, Varela-Fascinetto G, Valencia P, Pérez Tamayo R, Rosado CG, Labonne BF, Rochilin NM, Garcia RM, Valadez JA, Latour GT, Corona DL, Diaz GR, Zlotnik A and Kershenobich D: Cellular senescence in livers from children with end stage liver disease. PLoS One. 5:e102312010. View Article : Google Scholar : PubMed/NCBI

32 

Enomoto K and Farber E: Kinetics of phenotypic maturation of remodeling of hyperplastic nodules during liver carcinogenesis. Cancer Res. 42:2330–2335. 1982.PubMed/NCBI

33 

Ziech D, Franco R, Pappa A and Panayiotidis MI: Reactive oxygen species (ROS) - induced genetic and epigenetic alterations in human carcinogenesis. Mutat Res. 711:167–173. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Torres L, Avila MA, Carretero MV, Latasa MU, Caballería J, López-Rodas G, Boukaba A, Lu SC, Franco L and Mato JM: Liver-specific methionine adenosyltransferase MAT1A gene expression is associated with a specific pattern of promoter methylation and histone acetylation: implications for MAT1A silencing during transformation. FASEB J. 14:95–102. 2004.

35 

Yang H, Huang ZZ, Zeng Z, Chen C, Selby RR and Lu SC: Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer. Am J Physiol Gastrointest Liver Physiol. 280:184–190. 2001.PubMed/NCBI

36 

Takayama K, Shimoda N, Takanaga S, Hozumi S and Kikuchi Y: Expression patterns of dnmt3aa, dnmt3ab and dnmt4 during development and fin regeneration in zebrafish. Gene Expr Patterns. 14:105–110. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Takasugi M, Hayakawa K, Arai D and Shiota K: Age- and sex-dependent DNA hypomethylation controlled by growth hormone in mouse liver. Mech Ageing Dev. 134:331–337. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Berman BP, Weisenberger DJ, Aman JF, Hinoue T, Ramjan Z, Liu Y, Noushmehr H, Lange CPE, van Dijk MC, Tollenaar RAEM, van den Berg D and Laird PW: Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains. Nat Genet. 44:40–46. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Hervouet E, Lalier L, Debien D, Cheray M, Geairon A, Rogniaux H, Loussouarn D, Martin SA, Vallette FM and Cartron PF: Disruption of Dnmt1/PCNA/UHRF1 interactions promotes tumorigenesis from human and mice glial cells. PLoS One. 5:e113332010. View Article : Google Scholar : PubMed/NCBI

40 

Mortusewicz O, Schermelleh L, Walter J, Cardoso MC and Leonhardt H: Recruitment of DNA methyltransferase I to DNA repair sites. Proc Natl Acad Sci. 102:8905–8909. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Gazin C, Wajapeyee N, Gobeil S, Virbasius CM and Green MR: An elaborate pathway required for Ras-mediated epigenetic silencing. Nature. 449:1073–1077. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Liu X, Gao Q, Li P, Zhao Q, Zhang J, Li J, Koseki H and Wong J: UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi methylated DNA and methylated H3K9. Nat Commun. View Article : Google Scholar : 2013.PubMed/NCBI

43 

Shamma A, Suzuki M, Hayashi N, Kobayashi M, Sasaki N, Nihiuchi T, Doki Y, Okamoto T, Kohno S, Muranaka H, Kitajima S, Yamamoto K and Takahashi C: ATM mediates pRB function to control DNMT1 protein stability and DNA methylation. Mol Cell Biol. 33:3113–3124. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Cartron PF, Blanquart C, Hervouet E, Gregoire M and Vallette FM: HDAC1-mSin3a-NCOR1, Dnmt3b-HDAC1-Egr1 and Dnmt1-PCNA-UHRF1-G9a regulate the NY-ESO1 gene expression. Mol Oncol. 7:452–463. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Xionga Y, Dowdya SC, Xueb A, Shujuana J, Eberhardtc NL, Podratza KC and Jianga SW: Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers. Gynecol Oncol. 96:601–609. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Valencia Antúnez CA, Taja Chayeb L, Rodríguez-Segura MÁ, López Álvarez GS, García-Cuéllar CM and Villa Treviño S: DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model. Oncol Rep 32: 2093-2103, 2014.
APA
Valencia Antúnez, C.A., Taja Chayeb, L., Rodríguez-Segura, M.Á., López Álvarez, G.S., García-Cuéllar, C.M., & Villa Treviño, S. (2014). DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model. Oncology Reports, 32, 2093-2103. https://doi.org/10.3892/or.2014.3462
MLA
Valencia Antúnez, C. A., Taja Chayeb, L., Rodríguez-Segura, M. Á., López Álvarez, G. S., García-Cuéllar, C. M., Villa Treviño, S."DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model". Oncology Reports 32.5 (2014): 2093-2103.
Chicago
Valencia Antúnez, C. A., Taja Chayeb, L., Rodríguez-Segura, M. Á., López Álvarez, G. S., García-Cuéllar, C. M., Villa Treviño, S."DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model". Oncology Reports 32, no. 5 (2014): 2093-2103. https://doi.org/10.3892/or.2014.3462
Copy and paste a formatted citation
x
Spandidos Publications style
Valencia Antúnez CA, Taja Chayeb L, Rodríguez-Segura MÁ, López Álvarez GS, García-Cuéllar CM and Villa Treviño S: DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model. Oncol Rep 32: 2093-2103, 2014.
APA
Valencia Antúnez, C.A., Taja Chayeb, L., Rodríguez-Segura, M.Á., López Álvarez, G.S., García-Cuéllar, C.M., & Villa Treviño, S. (2014). DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model. Oncology Reports, 32, 2093-2103. https://doi.org/10.3892/or.2014.3462
MLA
Valencia Antúnez, C. A., Taja Chayeb, L., Rodríguez-Segura, M. Á., López Álvarez, G. S., García-Cuéllar, C. M., Villa Treviño, S."DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model". Oncology Reports 32.5 (2014): 2093-2103.
Chicago
Valencia Antúnez, C. A., Taja Chayeb, L., Rodríguez-Segura, M. Á., López Álvarez, G. S., García-Cuéllar, C. M., Villa Treviño, S."DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model". Oncology Reports 32, no. 5 (2014): 2093-2103. https://doi.org/10.3892/or.2014.3462
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team