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November-2014 Volume 32 Issue 5

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International Journal of Molecular Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Immune responsive gene 1, a novel oncogene, increases the growth and tumorigenicity of glioma

  • Authors:
    • Jun Pan
    • Xiaoyong Zhao
    • Chunnan Lin
    • Hongchao Xu
    • Zhilin Yin
    • Tianzhu Liu
    • Shizhong Zhang
  • View Affiliations / Copyright

    Affiliations: The National Key Clinic Specialty, The Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510000, P.R. China, Department of Neurosurgery, Huadu Hospital, Southern Medical University, Guangzhou, Guangdong 510000, P.R. China
  • Pages: 1957-1966
    |
    Published online on: September 10, 2014
       https://doi.org/10.3892/or.2014.3474
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Abstract

Immune responsive gene 1 (IRG1) is highly expressed in mammalian macrophages during inflammation. However, the role of IRG1 in tumorigenesis remains unclear. In the present study, we aimed to clarify the epigenetic regulation and biological functions of IRG1 in glioma. We found that the expression level of IRG1 influenced the WHO stage in 140 glioma patients. Overexpression of IRG1 increased the growth, invasion, and tumorigenesis in U251 and SHG-44 glioma cells both in vitro and in vivo. Suppression of IRG1 expression by si-IRG1 decreased the levels of cell cycle regulatory proteins, namely, E2F1, p21, CDK4, CDK6 and cyclin D1. Knockdown of IRG1 expression by RNA interference increased E-cadherin expression and decreased the amounts of snail and vimentin. Furthermore, the suppression of IRG1 expression inhibited the expression of NF-κB and STAT3, suggesting a role of IRG1 in regulating the genes associated with these factors and thereby contributing to a decrease in glioma cell proliferation, migration and invasion. Collectively, our findings revealed that IRG1 is a candidate oncogene that is amplified in glioma and is involved in novel mechanisms that influence glioma pathogenesis.
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1 

Hamza MA and Gilbert M: Targeted therapy in gliomas. Curr Oncol Rep. 16:3792014. View Article : Google Scholar

2 

Kaufmann JK and Chiocca EA: Glioma virus therapies between bench and bedside. Neuro Oncol. 16:334–351. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Lohkamp B, Bauerle B, Rieger PG and Schneider G: Three-dimensional structure of iminodisuccinate epimerase defines the fold of the MmgE/PrpD protein family. J Mol Biol. 362:555–566. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Lee CG, Demarquoy J, Jackson MJ and O’Brien WE: Molecular cloning and characterization of a murine LPS-inducible cDNA. J Immunol. 152:5758–5767. 1994.PubMed/NCBI

5 

Gautam A, Dixit S, Philipp MT, et al: Interleukin-10 alters effector functions of multiple genes induced by Borrelia burgdorferi in macrophages to regulate Lyme disease inflammation. Infect Immun. 79:4876–4892. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Li Y, Zhang P, Wang C, et al: Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species. J Biol Chem. 288:16225–16234. 2013. View Article : Google Scholar

7 

Lee CG, Jenkins NA, Gilbert DJ, Copeland NG and O’Brien WE: Cloning and analysis of gene regulation of a novel LPS-inducible cDNA. Immunogenetics. 41:263–270. 1995.PubMed/NCBI

8 

Shi S, Blumenthal A, Hickey CM, Gandotra S, Levy D and Ehrt S: Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1. J Immunol. 175:3318–3328. 2005.PubMed/NCBI

9 

Muccioli M, Sprague L, Nandigam H, Pate M and Benencia F: Toll-like receptors as novel therapeutic targets for ovarian cancer. ISRN Oncol. 2012:6421412012.PubMed/NCBI

10 

Hall CJ, Boyle RH, Astin JW, et al: Immunoresponsive gene 1 augments bactericidal activity of macrophage-lineage cells by regulating β-oxidation-dependent mitochondrial ROS production. Cell Metab. 18:265–278. 2013.PubMed/NCBI

11 

Chiba Y, Mizoguchi I, Mitobe K, et al: IL-27 enhances the expression of TRAIL and TLR3 inhuman melanomas and inhibits their tumor growth in cooperation with a TLR3 agonist poly(I:C) partly in a TRAIL-dependent manner. PLoS One. 8:e761592013. View Article : Google Scholar : PubMed/NCBI

12 

Song Q, Li Y, Zheng X, et al: MTA1 contributes to actin cytoskeleton reorganization and metastasis of nasopharyngeal carcinoma by modulating Rho GTPases and Hedgehog signaling. Int J Biochem Cell Biol. 45:1439–1446. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Lathia JD, Li M, Hall PE, et al: Laminin alpha 2 enables glioblastoma stem cell growth. Ann Neurol. 72:766–778. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Cheng L, Huang Z, Zhou W, et al: Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth. Cell. 153:139–152. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Islam KN, Bae JW, Gao E and Koch WJ: Regulation of nuclear factor κB (NF-κB) in the nucleus of cardiomyocytes by G protein-coupled receptor kinase 5 (GRK5). J Biol Chem. 288:35683–35689. 2013.

16 

Cheah SC, Lai SL, Lee ST, Hadi AH and Mustafa MR: Panduratin A, a possible inhibitor in metastasized A549 cells through inhibition of NF-kappa B translocation and chemo-invasion. Molecules. 18:8764–8778. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Zhao L, Wang H, Sun X and Ding Y: Comparative proteomic analysis identifies proteins associated with the development and progression of colorectal carcinoma. FEBS J. 277:4195–4204. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Wang F, Qiao Y, Yu J, et al: FBX8 acts as an invasion and metastasis suppressor and correlates with poor survival in hepatocellular carcinoma. PLoS One. 8:e654952013. View Article : Google Scholar : PubMed/NCBI

19 

Huang J, Ye X, Guan J, et al: Tiam1 is associated with hepatocellular carcinoma metastasis. Int J Cancer. 132:90–100. 2013. View Article : Google Scholar

20 

Michelucci A, Cordes T, Ghelfi J, et al: Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proc Natl Acad Sci USA. 110:7820–7825. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Kovesdi I, Reichel R and Nevins JR: E1A transcription induction: enhanced binding of a factor to upstream promoter sequences. Science. 231:719–722. 1986. View Article : Google Scholar : PubMed/NCBI

22 

Wang WJ, Wu SP, Liu JB, et al: MYC regulation of CHK1 and CHK2 promotes radioresistance in a stem cell-like population of nasopharyngeal carcinoma cells. Cancer Res. 73:1219–1231. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Lee HH, Lee SR and Leem SH: Tristetraprolin regulates prostate cancer cell growth through suppression of E2F1. J Microbiol Biotechnol. 24:287–294. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Kim MK, Kang YJ, Kim DH, et al: A novel hydroxamic acid derivative, MHY218, induces apoptosis and cell cycle arrest through downregulation of NF-κB in HCT116 human colon cancer cells. Int J Oncol. 44:256–264. 2014.PubMed/NCBI

25 

Kim A, Yim NH, Im M, Jung YP, Kim T and Ma JY: Suppression of the invasive potential of highly malignant tumor cells by KIOM-C, a novel herbal medicine, via inhibition of NF-κB activation and MMP-9 expression. Oncol Rep. 31:287–297. 2014.PubMed/NCBI

26 

Zhang W and Grivennikov SI: Top Notch cancer stem cells by paracrine NF-κB signaling in breast cancer. Breast Cancer Res. 15:3162013.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Pan J, Zhao X, Lin C, Xu H, Yin Z, Liu T and Zhang S: Immune responsive gene 1, a novel oncogene, increases the growth and tumorigenicity of glioma. Oncol Rep 32: 1957-1966, 2014.
APA
Pan, J., Zhao, X., Lin, C., Xu, H., Yin, Z., Liu, T., & Zhang, S. (2014). Immune responsive gene 1, a novel oncogene, increases the growth and tumorigenicity of glioma. Oncology Reports, 32, 1957-1966. https://doi.org/10.3892/or.2014.3474
MLA
Pan, J., Zhao, X., Lin, C., Xu, H., Yin, Z., Liu, T., Zhang, S."Immune responsive gene 1, a novel oncogene, increases the growth and tumorigenicity of glioma". Oncology Reports 32.5 (2014): 1957-1966.
Chicago
Pan, J., Zhao, X., Lin, C., Xu, H., Yin, Z., Liu, T., Zhang, S."Immune responsive gene 1, a novel oncogene, increases the growth and tumorigenicity of glioma". Oncology Reports 32, no. 5 (2014): 1957-1966. https://doi.org/10.3892/or.2014.3474
Copy and paste a formatted citation
x
Spandidos Publications style
Pan J, Zhao X, Lin C, Xu H, Yin Z, Liu T and Zhang S: Immune responsive gene 1, a novel oncogene, increases the growth and tumorigenicity of glioma. Oncol Rep 32: 1957-1966, 2014.
APA
Pan, J., Zhao, X., Lin, C., Xu, H., Yin, Z., Liu, T., & Zhang, S. (2014). Immune responsive gene 1, a novel oncogene, increases the growth and tumorigenicity of glioma. Oncology Reports, 32, 1957-1966. https://doi.org/10.3892/or.2014.3474
MLA
Pan, J., Zhao, X., Lin, C., Xu, H., Yin, Z., Liu, T., Zhang, S."Immune responsive gene 1, a novel oncogene, increases the growth and tumorigenicity of glioma". Oncology Reports 32.5 (2014): 1957-1966.
Chicago
Pan, J., Zhao, X., Lin, C., Xu, H., Yin, Z., Liu, T., Zhang, S."Immune responsive gene 1, a novel oncogene, increases the growth and tumorigenicity of glioma". Oncology Reports 32, no. 5 (2014): 1957-1966. https://doi.org/10.3892/or.2014.3474
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