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Article

Reversion of trichostatin A resistance via inhibition of the Wnt signaling pathway in human pancreatic cancer cells

  • Authors:
    • Benquan Wang
    • Qian Zou
    • Meng Sun
    • Jingfeng Chen
    • Tianyang Wang
    • Yongheng Bai
    • Zongjing Chen
    • Bicheng Chen
    • Mengtao Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Surgery The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China
  • Pages: 2015-2022
    |
    Published online on: September 10, 2014
       https://doi.org/10.3892/or.2014.3476
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Abstract

Drug resistance is a major impediment to successful chemotherapy in pancreatic cancer (PC) patients. We investigated the effect of Wnt/β-catenin signaling inhibition by wnt-c59 on chemoresistance in a trichostatin A-resistant Panc-1 cell line (Panc-1/TSA). Panc-1/TSA cells were treated with the Wnt/β‑catenin signaling inhibitor wnt-c59 (10 µmol · l-1) and/or trichostatin A (TSA; 10 µmol · l-1) for 24 h. CCK-8 assay was utilized to analyze the interactive effect of TSA and wnt-c59 on induction of apoptosis of the Panc-1/TSA cells. Cell apoptosis was measured by flow cytometry. Real-time PCR and western blotting were used to assess Wnt/β-catenin signaling, epithelial-mesenchymal transition (EMT) and multidrug resistance (MDR). Real-time cell analysis (RTCA) was used to detect the cell migration ability. After wnt-c59 treatment for 24 h, relative genes and transcriptional targets of Wnt/β-catenin signaling were downregulated (P<0.05). CCK-8 assay indicated that the combination of TSA and wnt-c59 had a synergistic effect on induction of Panc-1/TSA cell apoptosis. As detected by FACS, cell apoptosis rates increased significantly (P<0.05). The results of RTCA showed that the cell indices of the control group, wnt-c59 group, TSA group and TSA+wnt-c59 combination group were 1.2842±0.0257, 1.2155±0.0282, 1.2533±0.0194 and 0.8541±0.0250, respectively. In accordance, MMP-9 protein in the wnt-c59 treatment groups was decreased compared to the non-wnt-c59 treatment groups. Meanwhile, E-cadherin protein was upregulated and vimentin protein was downregulated, both of which are characteristic markers of EMT. Chemoresistant gene MDR1 and P-glycoprotein (P-gp) in the wnt-c59 treatment groups had a reduced expression compared to the non-wnt-c59 treatment groups. This study revealed that TSA sensitivity, migration ability, and the EMT phenotype in Panc-1/TSA cells were reversed following Wnt/β-catenin signaling inhibition.
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1 

Akita H, Doki Y, Miyata H, et al: Clinical significance of the second cycle response to cisplatin-based chemotherapy as preoperative treatment for esophageal squamous cell carcinoma. J Surg Oncol. 93:401–409. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Badiglian Filho L, Oshima CT, De Oliveira Lima F, et al: Canonical and noncanonical Wnt pathway: a comparison among normal ovary, benign ovarian tumor and ovarian cancer. Oncol Rep. 21:313–320. 2009.PubMed/NCBI

3 

Batova A, Shao LE, Diccianni MB, et al: The histone deacetylase inhibitor AN-9 has selective toxicity to acute leukemia and drug-resistant primary leukemia and cancer cell lines. Blood. 100:3319–3324. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Bordonaro M, Tewari S, Cicco CE, Atamna W and Lazarova DL: A switch from canonical to noncanonical Wnt signaling mediates drug resistance in colon cancer cells. PLoS One. 6:e273082011. View Article : Google Scholar : PubMed/NCBI

5 

Fournel M, Trachy-Bourget MC, Yan PT, et al: Sulfonamide anilides, a novel class of histone deacetylase inhibitors, are antiproliferative against human tumors. Cancer Res. 62:4325–4330. 2002.PubMed/NCBI

6 

Freese JL, Pino D and Pleasure SJ: Wnt signaling in development and disease. Neurobiol Dis. 38:148–153. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Ganesan A, Nolan L, Crabb SJ and Packham G: Epigenetic therapy: histone acetylation, DNA methylation and anti-cancer drug discovery. Curr Cancer Drug Targets. 9:963–981. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Gottesman MM, Fojo T and Bates SE: Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer. 2:48–58. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Greenhalf W and Thomas A: Combination therapy for the treatment of pancreatic cancer. Anticancer Agents Med Chem. 11:418–426. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Griesmann H, Ripka S, Pralle M, et al: WNT5A-NFAT signaling mediates resistance to apoptosis in pancreatic cancer. Neoplasia. 15:11–22. 2013.PubMed/NCBI

11 

Grimm M, Lazariotou M, Kircher S, et al: MMP-1 is a (pre-)invasive factor in Barrett-associated esophageal adenocarcinomas and is associated with positive lymph node status. J Transl Med. 8:992010. View Article : Google Scholar : PubMed/NCBI

12 

Hidalgo M and von Hoff DD: Translational therapeutic opportunities in ductal adenocarcinoma of the pancreas. Clin Cancer Res. 18:4249–4256. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Hong Y, Yang J, Wu W, et al: Knockdown of BCL2L12 leads to cisplatin resistance in MDA-MB-231 breast cancer cells. Biochim Biophys Acta. 1782:649–657. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Hung CC and Liou HH: YC-1, a novel potential anticancer agent, inhibits multidrug-resistant protein via cGMP-dependent pathway. Invest New Drugs. 29:1337–1346. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Inman GJ, Nicolas FJ, Callahan JF, et al: SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol. 62:65–74. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Kornmann M, Danenberg KD, Arber N, Beger HG, Danenberg PV and Korc M: Inhibition of cyclin D1 expression in human pancreatic cancer cells is associated with increased chemosensitivity and decreased expression of multiple chemoresistance genes. Cancer Res. 59:3505–3511. 1999.

17 

Le X, Shi Q, Wang B, et al: Molecular regulation of constitutive expression of interleukin-8 in human pancreatic adenocarcinoma. J Interferon Cytokine Res. 20:935–946. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Li Y, Van den Boom TG II, Kong D, et al: Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells. Cancer Res. 69:6704–6712. 2009. View Article : Google Scholar

19 

Liu X, Mazanek P, Dam V, et al: Deregulated Wnt/beta-catenin program in high-risk neuroblastomas without MYCN amplification. Oncogene. 27:1478–1488. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Liu Yong FY and Hui Wang: Synergistic augmentation of cisplatin-induced apoptosis in HeLa cells by rapamycin. Central China Med J. 33:300–303. 2009.

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Long J, Zhang Y, Yu X, et al: Overcoming drug resistance in pancreatic cancer. Expert Opin Ther Targets. 15:817–828. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Loos M, Kleeff J, Friess H and Büchler MW: Surgical treatment of pancreatic cancer. Ann NY Acad Sci. 1138:169–180. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Masckauchan TN, Shawber CJ, Funahashi Y, Li CM and Kitajewski J: Wnt/beta-catenin signaling induces proliferation, survival and interleukin-8 in human endothelial cells. Angiogenesis. 8:43–51. 2005. View Article : Google Scholar : PubMed/NCBI

25 

McCubrey JA, Steelman LS, Abrams SL, et al: Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance. Adv Enzyme Regul. 46:249–279. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Mellor HR and Callaghan R: Resistance to chemotherapy in cancer: a complex and integrated cellular response. Pharmacology. 81:275–300. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Mimeault M, Hauke R and Batra SK: Recent advances on the molecular mechanisms involved in the drug resistance of cancer cells and novel targeting therapies. Clin Pharmacol Ther. 83:673–691. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Mimeault M, Johansson SL, Senapati S, Momi N, Chakraborty S and Batra SK: MUC4 down-regulation reverses chemoresistance of pancreatic cancer stem/progenitor cells and their progenies. Cancer Lett. 295:69–84. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Moore PS, Barbi S, Donadelli M, et al: Gene expression profiling after treatment with the histone deacetylase inhibitor trichostatin A reveals altered expression of both pro- and anti-apoptotic genes in pancreatic adenocarcinoma cells. Biochim Biophys Acta. 1693:167–176. 2004. View Article : Google Scholar

30 

Nakagami H, Soukupova H, Schikora A, Zarsky V and Hirt H: A Mitogen-activated protein kinase mediates reactive oxygen species homeostasis in Arabidopsis. J Biol Chem. 281:38697–38704. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Neoptolemos JP, Stocken DD, Bassi C, et al: Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA. 304:1073–1081. 2010. View Article : Google Scholar

32 

Osborn MT and Chambers TC: Role of the stress-activated/c-Jun NH2-terminal protein kinase pathway in the cellular response to adriamycin and other chemotherapeutic drugs. J Biol Chem. 271:30950–30955. 1996. View Article : Google Scholar

33 

Qiao Q, Ramadani M, Gansauge S, Gansauge F, Leder G and Beger HG: Reduced membranous and ectopic cytoplasmic expression of beta-catenin correlate with cyclin D1 overexpression and poor prognosis in pancreatic cancer. Int J Cancer. 95:194–197. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Rocchi E, Khodjakov A, Volk EL, et al: The product of the ABC half-transporter gene ABCG2 (BCRP/MXR/ABCP) is expressed in the plasma membrane. Biochem Biophys Res Commun. 271:42–46. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Sayat R, Leber B, Grubac V, Wiltshire L and Persad S: O-GlcNAc-glycosylation of beta-catenin regulates its nuclear localization and transcriptional activity. Exp Cell Res. 314:2774–2787. 2008. View Article : Google Scholar

36 

Shah AN, Summy JM, Zhang J, Park SI, Parikh NU and Gallick GE: Development and characterization of gemcitabine-resistant pancreatic tumor cells. Ann Surg Oncol. 14:3629–3637. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Siegel R, Ward E, Brawley O and Jemal A: Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin. 61:212–236. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Su HY, Lai HC, Lin YW, et al: Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway. Int J Cancer. 127:555–567. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Vaccaro V, Melisi D, Bria E, et al: Emerging pathways and future targets for the molecular therapy of pancreatic cancer. Expert Opin Ther Targets. 15:1183–1196. 2011. View Article : Google Scholar : PubMed/NCBI

40 

van Hinsbergh VW, Engelse MA and Quax PH: Pericellular proteases in angiogenesis and vasculogenesis. Arterioscler Thromb Vasc Biol. 26:716–728. 2006.PubMed/NCBI

41 

Wang Z, Li Y, Kong D, et al: Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway. Cancer Res. 69:2400–2407. 2009. View Article : Google Scholar

42 

Yao J, Cai HH, Wei JS, et al: Side population in the pancreatic cancer cell lines SW1990 and CFPAC-1 is enriched with cancer stem-like cells. Oncol Rep. 23:1375–1382. 2010.PubMed/NCBI

43 

Yochum GS, Sherrick CM, Macpartlin M and Goodman RH: A beta-catenin/TCF-coordinated chromatin loop at MYC integrates 5′ and 3′ Wnt responsive enhancers. Proc Natl Acad Sci USA. 107:145–150. 2010.PubMed/NCBI

44 

Yuan RH, Jeng YM, Hu RH, et al: Role of p53 and β-catenin mutations in conjunction with CK19 expression on early tumor recurrence and prognosis of hepatocellular carcinoma. J Gastrointest Surg. 15:321–329. 2011.

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Copy and paste a formatted citation
Spandidos Publications style
Wang B, Zou Q, Sun M, Chen J, Wang T, Bai Y, Chen Z, Chen B and Zhou M: Reversion of trichostatin A resistance via inhibition of the Wnt signaling pathway in human pancreatic cancer cells. Oncol Rep 32: 2015-2022, 2014.
APA
Wang, B., Zou, Q., Sun, M., Chen, J., Wang, T., Bai, Y. ... Zhou, M. (2014). Reversion of trichostatin A resistance via inhibition of the Wnt signaling pathway in human pancreatic cancer cells. Oncology Reports, 32, 2015-2022. https://doi.org/10.3892/or.2014.3476
MLA
Wang, B., Zou, Q., Sun, M., Chen, J., Wang, T., Bai, Y., Chen, Z., Chen, B., Zhou, M."Reversion of trichostatin A resistance via inhibition of the Wnt signaling pathway in human pancreatic cancer cells". Oncology Reports 32.5 (2014): 2015-2022.
Chicago
Wang, B., Zou, Q., Sun, M., Chen, J., Wang, T., Bai, Y., Chen, Z., Chen, B., Zhou, M."Reversion of trichostatin A resistance via inhibition of the Wnt signaling pathway in human pancreatic cancer cells". Oncology Reports 32, no. 5 (2014): 2015-2022. https://doi.org/10.3892/or.2014.3476
Copy and paste a formatted citation
x
Spandidos Publications style
Wang B, Zou Q, Sun M, Chen J, Wang T, Bai Y, Chen Z, Chen B and Zhou M: Reversion of trichostatin A resistance via inhibition of the Wnt signaling pathway in human pancreatic cancer cells. Oncol Rep 32: 2015-2022, 2014.
APA
Wang, B., Zou, Q., Sun, M., Chen, J., Wang, T., Bai, Y. ... Zhou, M. (2014). Reversion of trichostatin A resistance via inhibition of the Wnt signaling pathway in human pancreatic cancer cells. Oncology Reports, 32, 2015-2022. https://doi.org/10.3892/or.2014.3476
MLA
Wang, B., Zou, Q., Sun, M., Chen, J., Wang, T., Bai, Y., Chen, Z., Chen, B., Zhou, M."Reversion of trichostatin A resistance via inhibition of the Wnt signaling pathway in human pancreatic cancer cells". Oncology Reports 32.5 (2014): 2015-2022.
Chicago
Wang, B., Zou, Q., Sun, M., Chen, J., Wang, T., Bai, Y., Chen, Z., Chen, B., Zhou, M."Reversion of trichostatin A resistance via inhibition of the Wnt signaling pathway in human pancreatic cancer cells". Oncology Reports 32, no. 5 (2014): 2015-2022. https://doi.org/10.3892/or.2014.3476
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