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December-2014 Volume 32 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Effects of doxorubicin and gemcitabine on the induction of apoptosis in breast cancer cells

  • Authors:
    • Rui-Rui Zheng
    • Wei Hu
    • Cheng-Guang Sui
    • Nan Ma
    • You-Hong Jiang
  • View Affiliations / Copyright

    Affiliations: Cancer Research Institute, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, P.R. China
  • Pages: 2719-2725
    |
    Published online on: September 24, 2014
       https://doi.org/10.3892/or.2014.3513
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Abstract

Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer-related mortality in females worldwide. The efficacy of chemotherapeutic drugs on breast cancer is hindered by many factors, including that cancer stem-like side population (SP) cells may contribute to tumorigenesis and resistance to chemotherapy. Doxorubicin and gemcitabine are two of the most effective and widely used chemotherapeutic agents for the treatment of various human malignancies. To the best of our knowledge, the effects of doxorubicin and gemcitabine on breast cancer SP cells are poorly understood. In the present study, we examined the potential roles of doxorubicin and gemcitabine in breast cancer main population (MP) and SP cells, and the mechanisms of doxorubicin and gemcitabine. The results showed that doxorubicin and gemcitabine decreasede proliferation, and increased apoptosis in the MCF7 MP and SP cells in vitro. Furthermore, doxorubicin and gemcitabine inhibited tumor growth and improved the survival rate of mice in vivo. Additionally, the mechanisms of doxorubicin and gemcitabine in MCF7 MP and SP cells were determined.
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Copy and paste a formatted citation
Spandidos Publications style
Zheng R, Hu W, Sui C, Ma N and Jiang Y: Effects of doxorubicin and gemcitabine on the induction of apoptosis in breast cancer cells. Oncol Rep 32: 2719-2725, 2014.
APA
Zheng, R., Hu, W., Sui, C., Ma, N., & Jiang, Y. (2014). Effects of doxorubicin and gemcitabine on the induction of apoptosis in breast cancer cells. Oncology Reports, 32, 2719-2725. https://doi.org/10.3892/or.2014.3513
MLA
Zheng, R., Hu, W., Sui, C., Ma, N., Jiang, Y."Effects of doxorubicin and gemcitabine on the induction of apoptosis in breast cancer cells". Oncology Reports 32.6 (2014): 2719-2725.
Chicago
Zheng, R., Hu, W., Sui, C., Ma, N., Jiang, Y."Effects of doxorubicin and gemcitabine on the induction of apoptosis in breast cancer cells". Oncology Reports 32, no. 6 (2014): 2719-2725. https://doi.org/10.3892/or.2014.3513
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng R, Hu W, Sui C, Ma N and Jiang Y: Effects of doxorubicin and gemcitabine on the induction of apoptosis in breast cancer cells. Oncol Rep 32: 2719-2725, 2014.
APA
Zheng, R., Hu, W., Sui, C., Ma, N., & Jiang, Y. (2014). Effects of doxorubicin and gemcitabine on the induction of apoptosis in breast cancer cells. Oncology Reports, 32, 2719-2725. https://doi.org/10.3892/or.2014.3513
MLA
Zheng, R., Hu, W., Sui, C., Ma, N., Jiang, Y."Effects of doxorubicin and gemcitabine on the induction of apoptosis in breast cancer cells". Oncology Reports 32.6 (2014): 2719-2725.
Chicago
Zheng, R., Hu, W., Sui, C., Ma, N., Jiang, Y."Effects of doxorubicin and gemcitabine on the induction of apoptosis in breast cancer cells". Oncology Reports 32, no. 6 (2014): 2719-2725. https://doi.org/10.3892/or.2014.3513
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