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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December-2014 Volume 32 Issue 6

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

IGF axis and other factors in HPV-related and HPV-unrelated carcinogenesis (Review)

Julia Durzyńska
Pages: 2295-2306
Published online on: 19 September 2014

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Article Open Access

The S100A4 D10V polymorphism is related to cell migration ability but not drug resistance in gastric cancer cells

Tein-Ming Yuan, Ruei-Yue Liang, Nai-Wan Hsiao, Show-Mei Chuang
Pages: 2307-2318
Published online on: 13 October 2014

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Article Open Access

Repeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse models

Nozomu Tanaka, Kazuki Sakamoto, Hiroyuki Okabe, Akio Fujioka, Keisuke Yamamura, Fumio Nakagawa, Hideki Nagase, Tatsushi Yokogawa, Kei Oguchi, Keiji Ishida, Akiko Osada, Hiromi Kazuno, Yukari Yamada, Kenichi Matsuo
Pages: 2319-2326
Published online on: 17 September 2014

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Article Open Access

Global expression profile in low grade meningiomas and schwannomas shows upregulation of PDGFD, CDH1 and SLIT2 compared to their healthy tissue

Miguel Torres-Martin, Luis Lassaletta, Alberto Isla, Jose M. De Campos, Giovanny R. Pinto, Rommel R. Burbano, Javier S. Castresana, Barbara Melendez, Juan A. Rey
Pages: 2327-2334
Published online on: 03 October 2014

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Article Open Access

Suppression of mucin 2 promotes interleukin-6 secretion and tumor growth in an orthotopic immune-competent colon cancer animal model

Yan-Shen Shan, Hui-Ping Hsu, Ming-Derg Lai, Meng-Chi Yen, Jung-Hua Fang, Tzu-Yang Weng, Yi-Ling Chen
Pages: 2335-2342
Published online on: 13 October 2014

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Article Open Access

Knockdown of glucose-regulated protein 78 enhances poly(ADP-ribose) polymerase cleavage in human pancreatic cancer cells exposed to endoplasmic reticulum stress

Xia Jiang, Tatsuo Kanda, Shingo  Nakamoto, Yuki  Haga, Reina  Sasaki, Masato Nakamura, Shuang  Wu, Rintaro Mikata, Osamu  Yokosuka
Pages: 2343-2348
Published online on: 06 October 2014

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Article Open Access

Expression of genes encoding extracellular matrix proteins: A macroarray study

Konrad Futyma, Paweł Miotła, Krystyna  Różyńska, Małgorzata Zdunek, Andrzej  Semczuk, Tomasz Rechberger, Jacek Wojcierowski
Pages: 2349-2353
Published online on: 17 September 2014

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Article

Circulating miR-199a-3p as a novel serum biomarker for colorectal cancer

Ryoji Nonaka, Junichi Nishimura, Yoshinori Kagawa, Hideki Osawa, Junichi Hasegawa, Kohei Murata, Shu Okamura, Hirofumi Ota, Mamoru Uemura, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Daisuke Okuzaki, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori
Pages: 2354-2358
Published online on: 24 September 2014

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Article

Possible involvement of tumor-producing VEGF-A in the recruitment of lymphatic endothelial progenitor cells from bone marrow

Masahiro Tawada, Shin-Ichiro Hayashi, Yuka Ikegame, Shigeru Nakashima, Kazuhiro Yoshida
Pages: 2359-2364
Published online on: 19 September 2014

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Article

miR-379/411 cluster regulates IL-18 and contributes to drug resistance in malignant pleural mesothelioma

Kazuo Yamamoto, Masahiro Seike, Susumu Takeuchi, Chie Soeno, Akihiko Miyanaga, Rintaro Noro, Yuji Minegishi, Kaoru Kubota, Akihiko Gemma
Pages: 2365-2372
Published online on: 16 September 2014

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Article

Modulated electro-hyperthermia enhances dendritic cell therapy through an abscopal effect in mice

Wei Qin, Yasunori Akutsu, Gabor Andocs, Akiko Suganami, Xin Hu, Gulbostan Yusup, Aki Komatsu-Akimoto, Isamu Hoshino, Naoyuki Hanari, Mikito Mori, Yuka Isozaki, Naoki Akanuma, Yutaka Tamura, Hisahiro Matsubara
Pages: 2373-2379
Published online on: 19 September 2014

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Article

Immediate and transient phosphorylation of the heat shock protein 27 initiates chemoresistance in prostate cancer cells

Matthias B. Stope, Martin Weiss, Melanie Preuss, Andreas  Streitbörger, Christoph A. Ritter, Uwe Zimmermann, Reinhard Walther, Martin Burchardt
Pages: 2380-2386
Published online on: 17 September 2014

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Article

CXCR7 correlates with the differentiation of hepatocellular carcinoma and suppresses HNF4α expression through the ERK pathway

Tong-Chun Xue, Qing-An Jia, Yang Bu, Rong-Xin Chen, Jie‑Feng Cui, Zhao-You Tang, Sheng-Long Ye
Pages: 2387-2396
Published online on: 19 September 2014

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Article

Krüppel-like factor 8 involved in hypoxia promotes the invasion and metastasis of gastric cancer via epithelial to mesenchymal transition

Na Liu, Yafang Wang, Yongan Zhou, Hailin Pang, Jing Zhou, Pei Qian, Lili Liu, Helong Zhang
Pages: 2397-2404
Published online on: 18 September 2014

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Article

Development of a 5-fluorouracil-loaded PLGA microsphere delivery system by a solid-in-oil-in-hydrophilic oil (S/O/hO) novel method for the treatment of tumors

Qing Lin, Yunpeng Cai, Minglu Yuan, Lin  Ma, Mingfeng  Qiu, Jing  Su
Pages: 2405-2410
Published online on: 16 September 2014

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Adenovirus-mediated siRNA targeting NOB1 inhibits tumor growth and enhances radiosensitivity of human papillary thyroid carcinoma in vitro and in vivo

Wei Meng, Pei-Song Wang, Jia Liu, Shuai Xue, Gui-Min Wang, Xian-Ying Meng, Guang Chen
Pages: 2411-2420
Published online on: 16 September 2014

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Article

The mechanisms responsible for the radiosensitizing effects of sorafenib on colon cancer cells

Eun Ho Kim, Mi-Sook Kim, Won-Gyun Jung
Pages: 2421-2428
Published online on: 18 September 2014

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Article

Geldanamycin mediates the apoptosis of gastric carcinoma cells through inhibition of EphA2 protein expression

Da-Hu Wang, Yu-Jun Zhang, San-Bing Zhang, Hui Liu, Liang Liu, Feng-Ling Liu, Jing Zuo
Pages: 2429-2436
Published online on: 13 October 2014

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Article

Overexpression of CD133 enhances chemoresistance to 5-fluorouracil by activating the PI3K/Akt/p70S6K pathway in gastric cancer cells

Youlong Zhu, Jiwei Yu, Shoulian Wang, Ruiqi  Lu, Jugang Wu, Bojian Jiang
Pages: 2437-2444
Published online on: 17 September 2014

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Article

Allelic loss at chromosome 11q13 alters FGF3 gene expression in a human breast cancer progression model

Debasish Roy, Gloria M. Calaf
Pages: 2445-2452
Published online on: 19 September 2014

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Article

Relationship between expression of Livin and the biological behavior of human oral squamous cell carcinoma

Dong Hoon Lee, Tae Mi Yoon, Sun-Ae Kim, Young-Lan Park, Kyung-Hwa Lee, Sang Chul Lim, Joon Kyoo Lee, Young Eun Joο
Pages: 2453-2460
Published online on: 22 September 2014

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Article

Induction of apoptosis in MDA-MB-231 human breast carcinoma cells with an ethanol extract of Cyperus rotundus L. by activating caspases

Sang Eun Park, Won Tak Shin, Cheol Park, Su Hyun Hong, Gi-Young Kim, Sung Ok Kim, Chung Ho Ryu, Sang Hoon Hong, Yung Hyun Choi
Pages: 2461-2470
Published online on: 22 September 2014

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Article

Expression and roles of fatty acid synthase in hepatocellular carcinoma

Qiwei Hao, Tao Li, Xiong Zhang, Ping Gao, Peiyu Qiao, Sheng Li, Zhimin Geng
Pages: 2471-2476
Published online on: 16 September 2014

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Article

Vascular endothelial growth factor plays a critical role in the formation of the pre-metastatic niche via prostaglandin E2

Shili Liu, Man Jiang, Qiang Zhao, Shancheng Li, Yanping Peng, Pengfei Zhang, Mingyong Han
Pages: 2477-2484
Published online on: 24 September 2014

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Article

Elevated expression level of long noncoding RNA MALAT-1 facilitates cell growth, migration and invasion in pancreatic cancer

Feng Jiao, Hai Hu, Cuncun Yuan, Lei Wang, Weihua Jiang, Ziliang Jin, Zhen Guo, Liwei Wang
Pages: 2485-2492
Published online on: 26 September 2014

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Article

Upregulation of stromal cell-derived factor 1α expression is associated with the resistance to neoadjuvant chemoradiotherapy of locally advanced rectal cancer: Angiogenic markers of neoadjuvant chemoradiation

Han Jo Kim, Sang Byung Bae, Dongjun Jeong, Eun Seog Kim, Chang-Nam Kim, Dong-Guk Park, Tae Sung Ahn, Sung Woo Cho, Eung Jin Shin, Moon Soo Lee, Moo Jun Baek
Pages: 2493-2500
Published online on: 19 September 2014

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Article

Synergistic effects of co-expression plasmid‑based ADAM10-specific siRNA and GRIM-19 on hepatocellular carcinoma in vitro and in vivo Retraction in /10.3892/or.2021.8235

Songyang Liu, Wei Zhang, Kai Liu, Yingchao Wang, Bai Ji, Yahui Liu
Pages: 2501-2510
Published online on: 19 September 2014

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Article

Restoration of miR-7 expression suppresses the growth of Lewis lung cancer cells by modulating epidermal growth factor receptor signaling

Jingrong Li, Yijie Zheng, Gengyun Sun, Shudao Xiong
Pages: 2511-2516
Published online on: 26 September 2014

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Article

Association of p53/p21 expression and cigarette smoking with tumor progression and poor prognosis in non-small cell lung cancer patients

Deyao Xie, Linhua Lan, Kate Huang, Lin Chen, Cuicui Xu, Rongrong Wang, Yang Shi, Xiaoyi Wu, Lu Wang, Yongzhang Liu, Bin Lu
Pages: 2517-2526
Published online on: 10 October 2014

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Article

Celastrol induces the apoptosis of breast cancer cells and inhibits their invasion via downregulation of MMP-9

Chunliu Mi, Hui Shi, Juan Ma, Li Zhuo Han, Jung Joon Lee, Xuejun Jin
Pages: 2527-2532
Published online on: 10 October 2014

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Article

SPAG9 expression is increased in human prostate cancer and promotes cell motility, invasion and angiogenesis in vitro Corrigendum in /10.3892/or.2022.8314

Feifei Chen, Zheng Lu, Junpeng Deng, Xuechao Han, Jin Bai, Qinghua Liu, Yaguang Xi, Junnian Zheng
Pages: 2533-2540
Published online on: 10 October 2014

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Article

P-cadherin potentiates ligand-dependent EGFR and IGF-1R signaling in dysplastic and malignant oral keratinocytes

Desseree Lysne, James Johns, Andrew Walker, Rachel Ecker, Christopher Fowler, Kathryn R. Lawson
Pages: 2541-2548
Published online on: 14 October 2014

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Article

Regulation of BGC-823 cell sensitivity to adriamycin via miRNA-135a-5p

Yanming Pan, Fengyun Ren, Wei Zhang, Guibo Liu, Dan Yang, Jing Hu, Kejian Feng, Yukuan Feng
Pages: 2549-2556
Published online on: 14 October 2014

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Article

Annexin A5 inhibits diffuse large B-cell lymphoma cell invasion and chemoresistance through phosphatidylinositol 3-kinase signaling

Jingjing Wang, Yang Zhang, Xianling Liu, Jinan Ma, Ping Liu, Chunhong Hu, Guangsen Zhang
Pages: 2557-2563
Published online on: 14 October 2014

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Article

A new version of targeted minicircle producer system for EBV-positive human nasopharyngeal carcinoma

Yufang Zuo, Sihai Liao, Zumin Xu, Jierong Xie, Wenlin Huang, Zhonghua Yu
Pages: 2564-2570
Published online on: 17 September 2014

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Article

Reduced expression of SRY-box containing gene 17 correlates with an unfavorable melanoma patient survival

Jing Lu, Guohong Zhang, Yabin Cheng, Yun Tang, Ziming Dong, Kevin J. McElwee, Gang Li
Pages: 2571-2579
Published online on: 08 October 2014

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Article

RUNX3 is inactivated by promoter hypermethylation in malignant transformation of ovarian endometriosis

Cuishan Guo, Fang Ren, Danbo Wang, Yan Li, Kuiran Liu, Shuang Liu, Peng Chen
Pages: 2580-2588
Published online on: 03 October 2014

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Article

NAD(P)H:quinone oxidoreductase-1 overexpression predicts poor prognosis in small cell lung cancer

Xuelian Cui, Tiefeng Jin, Xiaoyan Wang, Guang Jin, Zhuhu Li, Lijuan Lin
Pages: 2589-2595
Published online on: 17 September 2014

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Article

Metformin inhibits the growth of nasopharyngeal carcinoma cells and sensitizes the cells to radiation via inhibition of the DNA damage repair pathway

Haiwen Li, Xinggui Chen, Ying Yu, Zhennan Wang, Yufang Zuo, Shuhui Li, Donghong Yang, Shengwen Hu, Mei Xiang, Zumin Xu, Zhonghua Yu
Pages: 2596-2604
Published online on: 17 September 2014

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Article

Potential role of the OPG/RANK/RANKL axis in prostate cancer invasion and bone metastasis

Xiaoming Li, Yaoming Liu, Bin Wu, Zhilong Dong, Yichen Wang, Jianzhong Lu, Ping Shi, Wenlong Bai, Zhiping Wang
Pages: 2605-2611
Published online on: 23 September 2014

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Article

SB365, Pulsatilla saponin D, suppresses the growth of gefitinib-resistant NSCLC cells with Met amplification

Won-Jun Jang, Byoungduck Park, Gil-Saeng  Jeong, Soon-Sun Hong, Chul-Ho Jeong
Pages: 2612-2618
Published online on: 03 October 2014

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Article

Membrane-bound complement regulatory proteins are prognostic factors of operable breast cancer treated with adjuvant trastuzumab: A retrospective study

Mei Liu, Ya-Jun Yang, Hong Zheng, Xiao-Rong Zhong, Yu Wang, Zhu Wang, Yao-Geng Wang, Yan-Ping Wang
Pages: 2619-2627
Published online on: 18 September 2014

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Article

Loss of ALCAM expression is linked to adverse phenotype and poor prognosis in breast cancer: A TMA-based immunohistochemical study on 2,197 breast cancer patients

Eike Burandt, Tanaz Bari Noubar, Annette Lebeau, Sarah  Minner, Christoph Burdelski, Fritz  Jänicke, Vollkmar  Müller, Luigi  Terracciano, Ronald  Simon, Guido Sauter, Waldemar  Wilczak, Patrick Lebok
Pages: 2628-2634
Published online on: 01 October 2014

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Article

Anticancer effects of β-elemene in gastric cancer cells and its potential underlying proteins: A proteomic study

Jun-Song Liu, Shi-Cai He, Zheng-Liang Zhang, Rui Chen, Lin Fan, Guang‑Lin Qiu, Shuai Chang, Liang Li, Xiang-Ming Che
Pages: 2635-2647
Published online on: 17 September 2014

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Article

Mechanism and biological significance of the overexpression of IFITM3 in gastric cancer

Jun Hu, Shuwei Wang, Yan Zhao, Qinhao  Guo, Dongsheng  Zhang, Jiejing Chen, Juan  Li, Qiang Fei, Yueming Sun
Pages: 2648-2656
Published online on: 01 October 2014

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Article

EphA3, induced by PC-1/PrLZ, contributes to the malignant progression of prostate cancer

Ruiqin Wu, Hongtao Wang, Jian Wang, Peng Wang, Fang Huang, Bangxiang Xie, Yali Zhao, Shanhu Li, Jianguang Zhou
Pages: 2657-2665
Published online on: 16 September 2014

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Article

Zerumbone suppresses EGF-induced CD44 expression through the inhibition of STAT3 in breast cancer cells

Sangmin Kim, Won Ho Kil, Jeongmin Lee, Soo-Jin Oh, Jeonghun Han, Myeongjin Jeon, Taewoo Jung, Se Kyung Lee, Soo Youn Bae, Hyun Chul Lee, Jun Ho Lee, Ha Woo Yi, Seok Won Kim, Seok Jin Nam, Jeong Eon Lee
Pages: 2666-2672
Published online on: 24 September 2014

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Article

Epithelial-mesenchymal transition in human papillomavirus‑positive and -negative oropharyngeal squamous cell carcinoma

Hiromitsu Hatakeyama, Takatsugu Mizumachi, Tomohiro Sakashita, Satoshi Kano, Akihiro Homma, Satoshi Fukuda
Pages: 2673-2679
Published online on: 22 September 2014

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Article

Role of the Wilms' tumor 1 gene in the aberrant biological behavior of leukemic cells and the related mechanisms

Yan Li, Jiying Wang, Xiaoyan Li, Yujiao Jia, Lei Huai, Kan He, Pei Yu, Min Wang, Haiyan Xing, Qing Rao, Zhen Tian, Kejing Tang, Jianxiang Wang, Yingchang Mi
Pages: 2680-2686
Published online on: 06 October 2014

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Article

Identification of PAQR3 as a new candidate tumor suppressor in hepatocellular carcinoma

Hong Ge Wu, Wen Jie Zhang, Qian Ding, Gang Peng, Zhen Wei Zou, Ting Liu, Ru Bo Cao, Shi Jiang Fei, Peng Cheng Li, Kun Yu Yang, Jian Li Hu, Xiang Fang Dai, Gang Wu, Pin Dong Li
Pages: 2687-2695
Published online on: 06 October 2014

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Article

Knockout of the HCC suppressor gene Lass2 downregulates the expression level of miR-694

Xiaodong Lu, Yuanyuan Chen, Tiantian Zeng, Lufang  Chen, Qixiang Shao, Wenxin Qin
Pages: 2696-2702
Published online on: 03 October 2014

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Article

CD38 is highly expressed and affects the PI3K/Akt signaling pathway in cervical cancer

Shan Liao, Songshu Xiao, Guangchao Zhu, Danwei Zheng, Junyu He, Zhen Pei, Guiyuan Li, Yanhong Zhou
Pages: 2703-2709
Published online on: 10 October 2014

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Article

Ethyl acetate extract from Jiedu Xiaozheng Yin inhibits the proliferation of human hepatocellular carcinoma cells by suppressing polycomb gene product Bmi1 and Wnt/β-catenin signaling

Xu-Zheng Chen, Zhi-Yun Cao, Jin-Nong Li, Hai-Xia Hu, You-Quan Zhang, Yun-Mei Huang, Zhi-Zhen Liu, Dan Hu, Lian-Ming Liao, Jian Du
Pages: 2710-2718
Published online on: 13 October 2014

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Article

Effects of doxorubicin and gemcitabine on the induction of apoptosis in breast cancer cells

Rui-Rui Zheng, Wei Hu, Cheng-Guang Sui, Nan Ma, You-Hong Jiang
Pages: 2719-2725
Published online on: 24 September 2014

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Article

Ubiquitin‑specific protease 22‑induced autophagy is correlated with poor prognosis of pancreatic cancer

Jin‑Xiao Liang, Zhen Ning, Wei Gao, Jun Ling, A‑Man Wang, Hai‑Feng Luo, Yong Liang, Qiu Yan, Zhong‑Yu Wang
Pages: 2726-2734
Published online on: 22 September 2014

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Article

Mitotic rate is a more reliable unfavorable prognosticator than ulceration for early cutaneous melanoma: A 5-year survival analysis

Piotr Donizy, Maciej Kaczorowski, Marek Leskiewicz, Marcin Zietek, Malgorzata Pieniazek, Cyprian Kozyra, Agnieszka Halon, Rafal Matkowski
Pages: 2735-2743
Published online on: 06 October 2014

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microRNA sponge blocks the tumor-suppressing functions of microRNA-122 in human hepatoma and osteosarcoma cells

Ji Ma, Qi Wu, Yue Zhang, Jinghua Li, Yongchun Yu, Qiuhui Pan, Fenyong Sun
Pages: 2744-2752
Published online on: 25 September 2014

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Article

Impact of the tumor microenvironment in predicting postoperative hepatic recurrence of pancreatic neuroendocrine tumors

Shoki Sato, Takahiro Tsuchikawa, Toru Nakamura, Nagato  Sato, Eiji  Tamoto, Keisuke Okamura, Toshiaki  Shichinohe, Satoshi Hirano
Pages: 2753-2759
Published online on: 06 October 2014

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Article

Activation of STAT3 is involved in malignancy mediated by CXCL12-CXCR4 signaling in human breast cancer

Xiaojian Liu, Qinghuan Xiao, Xuefeng Bai, Zhaojin Yu, Mingli Sun, Haishan Zhao, Xiaoyi Mi, Enhua Wang, Weifan Yao, Feng Jin, Lin Zhao, Jie Ren, Minjie Wei
Pages: 2760-2768
Published online on: 10 October 2014

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Article

Tunicamycin-induced ER stress regulates chemokine CCL5 expression and secretion via STAT3 followed by decreased transmigration of MCF-7 breast cancer cells

Yimin Zhang, Shichong Liao, Wei Fan, Wen Wei, Changhua Wang, Shengrong Sun
Pages: 2769-2776
Published online on: 16 September 2014

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Article

Berberine hydrochloride IL-8 dependently inhibits invasion and IL-8-independently promotes cell apoptosis in MDA-MB-231 cells

Xiang Li, Shu-Juan Zhao, Hai-Lian Shi, Shui-Ping Qiu, Jian-Qun Xie, Hui Wu, Bei-Bei Zhang, Zheng-Tao Wang, Jian-Ye Yuan, Xiao-Jun Wu
Pages: 2777-2788
Published online on: 30 September 2014

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Article

Combination of chloroquine and GX15-070 (obatoclax) results in synergistic cytotoxicity against pancreatic cancer cells

Guan Wang, Shaohua Chen, Holly Edwards, Xinming Cui, Li Cui, Yubin Ge
Pages: 2789-2794
Published online on: 03 October 2014

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Article

Fasudil inhibits prostate cancer-induced angiogenesis in vitro

Weihua Chen, Kaili Mao, Thong Hua-Huy, Yihua Bei, Zhongmin Liu, Anh-Tuan Dinh-Xuan
Pages: 2795-2802
Published online on: 17 September 2014

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Article

Potentiation of resveratrol-induced apoptosis by matrine in human hepatoma HepG2 cells

Xiuyuan Ou, Yan Chen, Xinxin Cheng, Xumeng Zhang, Qiyang He
Pages: 2803-2809
Published online on: 23 September 2014

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Article

Overexpression of syntenin enhances hepatoma cell proliferation and invasion: Potential roles in human hepatoma

Xuemin Liu, Xufeng Zhang, Yi Lv, Junxi Xiang, Jianhua Shi
Pages: 2810-2816
Published online on: 18 September 2014

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Article

C5a stimulates the proliferation of breast cancer cells via Akt-dependent RGC-32 gene activation

Yi Lu, Xiao-Bo Hu
Pages: 2817-2823
Published online on: 17 September 2014

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Article

MicroRNA-216a inhibits pancreatic cancer by directly targeting Janus kinase 2

Siliang Wang, Xiaodong Chen, Meiyue Tang
Pages: 2824-2830
Published online on: 15 September 2014

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Article

SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis

Li Lin, Xiaoxia Zheng, Chunping Qiu, Samina Dongol, Qingtao Lv, Jie Jiang, Beihua Kong, Chenguang Wang
Pages: 2831-2835
Published online on: 01 October 2014

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Article

Adrenocortical carcinoma in children: First population‑based clinicopathological study with long-term follow-up

T. M.A. Kerkhofs, M. H.T. Ettaieb, R. H.A. Verhoeven, G. J.L. Kaspers, W. J.E. Tissing, J. Loeffen, M. M. Van den Heuvel-Eibrink, R. R. De Krijger, H. R. Haak
Pages: 2836-2844
Published online on: 22 September 2014

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Article

Paeonol exerts an anticancer effect on human colorectal cancer cells through inhibition of PGE2 synthesis and COX-2 expression

Ming Li, Shi-Yun Tan, Xiao-Fan Wang
Pages: 2845-2853
Published online on: 13 October 2014

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Journal Cover
January-2026 Volume 55 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Article Open Access

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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Article Open Access

S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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Review Open Access

The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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Review Open Access

From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Review Open Access

Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Article Open Access

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Alternative splicing in cancer drug resistance: Mechanisms and therapeutic prospects (Review)

Wenpu Zhu, Zikun Wu, Chai Luv, Banghe Bao, Weijie Zhao, Guanglong Chen, Hang Yang, Huihan Ai, Faqiang Liu, Zhi Li
Article Number: 31
Published online on: 05 December 2025

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Article Open Access

Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Article Open Access

Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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