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Global expression profile in low grade meningiomas and schwannomas shows upregulation of PDGFD, CDH1 and SLIT2 compared to their healthy tissue

  • Authors:
    • Miguel Torres-Martin
    • Luis Lassaletta
    • Alberto Isla
    • Jose M. De Campos
    • Giovanny R. Pinto
    • Rommel R. Burbano
    • Javier S. Castresana
    • Barbara Melendez
    • Juan A. Rey
  • View Affiliations / Copyright

    Affiliations: Molecular Neuro-Oncogenetics Laboratory, Research Unit, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain, Department of Otolaryngology, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain, Department of Neurosurgery, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain, Department of Neurosurgery, Fundacion Jimenez Diaz, Madrid, Spain, Genetics and Molecular Biology Laboratory, Federal University of Piau, Parnaiba, Brazil, Human Cytogenetics Laboratory, Institute of Biological Sciences, Federal University of Para, Belem, Brazil, Department of Biochemistry and Genetics, University of Navarra School of Sciences, Pamplona, Spain, Molecular Pathology Research Unit, Virgen de la Salud Hospital, Toledo, Spain
    Copyright: © Torres-Martin et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 2327-2334
    |
    Published online on: October 3, 2014
       https://doi.org/10.3892/or.2014.3526
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Abstract

Schwannomas and grade I meningiomas are non‑metastatic neoplasms that share the common mutation of gene NF2. They usually appear in neurofibromatosis type 2 patients. Currently, there is no drug treatment available for both tumors, thus the use of wide expression technologies is crucial to identify therapeutic targets. Affymetrix Human Gene 1.0 ST was used to test global gene expression in 22 meningiomas, 31 schwannomas and, as non-tumoral controls, 3 healthy meningeal tissues, 8 non-tumoral nerves and 1 primary Schwann cell culture. A non-stringent P-value cut-off and fold change were used to establish deregulated genes. We identified a subset of genes that were upregulated in meningiomas and schwannomas when compared to their respectively healthy tissues, including PDGFD, CDH1 and SLIT2. Thus, these genes should be thoroughly studied as targets in a possible combined treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Torres-Martin M, Lassaletta L, Isla A, De Campos JM, Pinto GR, Burbano RR, Castresana JS, Melendez B and Rey JA: Global expression profile in low grade meningiomas and schwannomas shows upregulation of PDGFD, CDH1 and SLIT2 compared to their healthy tissue. Oncol Rep 32: 2327-2334, 2014.
APA
Torres-Martin, M., Lassaletta, L., Isla, A., De Campos, J.M., Pinto, G.R., Burbano, R.R. ... Rey, J.A. (2014). Global expression profile in low grade meningiomas and schwannomas shows upregulation of PDGFD, CDH1 and SLIT2 compared to their healthy tissue. Oncology Reports, 32, 2327-2334. https://doi.org/10.3892/or.2014.3526
MLA
Torres-Martin, M., Lassaletta, L., Isla, A., De Campos, J. M., Pinto, G. R., Burbano, R. R., Castresana, J. S., Melendez, B., Rey, J. A."Global expression profile in low grade meningiomas and schwannomas shows upregulation of PDGFD, CDH1 and SLIT2 compared to their healthy tissue". Oncology Reports 32.6 (2014): 2327-2334.
Chicago
Torres-Martin, M., Lassaletta, L., Isla, A., De Campos, J. M., Pinto, G. R., Burbano, R. R., Castresana, J. S., Melendez, B., Rey, J. A."Global expression profile in low grade meningiomas and schwannomas shows upregulation of PDGFD, CDH1 and SLIT2 compared to their healthy tissue". Oncology Reports 32, no. 6 (2014): 2327-2334. https://doi.org/10.3892/or.2014.3526
Copy and paste a formatted citation
x
Spandidos Publications style
Torres-Martin M, Lassaletta L, Isla A, De Campos JM, Pinto GR, Burbano RR, Castresana JS, Melendez B and Rey JA: Global expression profile in low grade meningiomas and schwannomas shows upregulation of PDGFD, CDH1 and SLIT2 compared to their healthy tissue. Oncol Rep 32: 2327-2334, 2014.
APA
Torres-Martin, M., Lassaletta, L., Isla, A., De Campos, J.M., Pinto, G.R., Burbano, R.R. ... Rey, J.A. (2014). Global expression profile in low grade meningiomas and schwannomas shows upregulation of PDGFD, CDH1 and SLIT2 compared to their healthy tissue. Oncology Reports, 32, 2327-2334. https://doi.org/10.3892/or.2014.3526
MLA
Torres-Martin, M., Lassaletta, L., Isla, A., De Campos, J. M., Pinto, G. R., Burbano, R. R., Castresana, J. S., Melendez, B., Rey, J. A."Global expression profile in low grade meningiomas and schwannomas shows upregulation of PDGFD, CDH1 and SLIT2 compared to their healthy tissue". Oncology Reports 32.6 (2014): 2327-2334.
Chicago
Torres-Martin, M., Lassaletta, L., Isla, A., De Campos, J. M., Pinto, G. R., Burbano, R. R., Castresana, J. S., Melendez, B., Rey, J. A."Global expression profile in low grade meningiomas and schwannomas shows upregulation of PDGFD, CDH1 and SLIT2 compared to their healthy tissue". Oncology Reports 32, no. 6 (2014): 2327-2334. https://doi.org/10.3892/or.2014.3526
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