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Article

Clinical significance of the FIB-4 index for non-B non-C hepatocellular carcinoma treated with surgical resection

  • Authors:
    • Hiroki Nishikawa
    • Yukio Osaki
    • Hideyuki Komekado
    • Azusa Sakamoto
    • Sumio  Saito
    • Norihiro Nishijima
    • Akihiro Nasu
    • Akira Arimoto
    • Ryuichi Kita
    • Toru Kimura
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Tennoji-ku, Osaka 543-0027, Japan, Department of Surgery, Osaka Red Cross Hospital, Tennoji-ku, Osaka 543-0027, Japan
  • Pages: 88-94
    |
    Published online on: October 30, 2014
       https://doi.org/10.3892/or.2014.3573
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Abstract

The aims of the present study were to examine the relationship between the preoperative FIB-4 index and background liver fibrosis in non-tumor parts obtained from surgical specimens and to investigate whether the FIB-4 index can be a useful predictor for non-B non-C hepatocellular carcinoma (NBNC-HCC) patients treated with surgical resection (SR). A total of 118 patients with NBNC-HCC treated with SR with curative intent were analyzed. Receiver operating characteristic (ROC) curve analysis was performed for calculating the area under the ROC (AUROC) for the FIB-4 index, aspartate aminotransferase (AST) to platelet ratio index, AST to alanine aminotransferase ratio, serum albumin, total bilirubin and platelet count for cirrhosis. We also examined predictors linked to overall survival (OS) and recurrence-free survival (RFS) after SR. The mean patient age was 68.9±9.0 years (93 males and 25 females) with a median observation period of 3.2 years. In extracted surgical specimens, background liver cirrhosis (F4) was observed in 39 patients (33.1%). The mean maximum tumor size was 5.7±3.2 cm. The mean body mass index was 24.3±3.9 kg/m2. The FIB-4 index yielded the highest AUROC for cirrhosis with a level of 0.887 at an optimal cut-off value of 2.97 (sensitivity, 92.3; specificity, 69.6%). In the multivariate analysis, serum α-fetoprotein >40 ng/ml (P=0.026) was the only significant independent predictor linked to OS, while tumor number (P=0.002) and FIB-4 index >2.97 (P=0.044) were significant factors linked to RFS. In conclusion, preoperative FIB-4 index can be a useful predictor for NBNC-HCC patients who undergo SR.
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Copy and paste a formatted citation
Spandidos Publications style
Nishikawa H, Osaki Y, Komekado H, Sakamoto A, Saito S, Nishijima N, Nasu A, Arimoto A, Kita R, Kimura T, Kimura T, et al: Clinical significance of the FIB-4 index for non-B non-C hepatocellular carcinoma treated with surgical resection. Oncol Rep 33: 88-94, 2015.
APA
Nishikawa, H., Osaki, Y., Komekado, H., Sakamoto, A., Saito, S., Nishijima, N. ... Kimura, T. (2015). Clinical significance of the FIB-4 index for non-B non-C hepatocellular carcinoma treated with surgical resection. Oncology Reports, 33, 88-94. https://doi.org/10.3892/or.2014.3573
MLA
Nishikawa, H., Osaki, Y., Komekado, H., Sakamoto, A., Saito, S., Nishijima, N., Nasu, A., Arimoto, A., Kita, R., Kimura, T."Clinical significance of the FIB-4 index for non-B non-C hepatocellular carcinoma treated with surgical resection". Oncology Reports 33.1 (2015): 88-94.
Chicago
Nishikawa, H., Osaki, Y., Komekado, H., Sakamoto, A., Saito, S., Nishijima, N., Nasu, A., Arimoto, A., Kita, R., Kimura, T."Clinical significance of the FIB-4 index for non-B non-C hepatocellular carcinoma treated with surgical resection". Oncology Reports 33, no. 1 (2015): 88-94. https://doi.org/10.3892/or.2014.3573
Copy and paste a formatted citation
x
Spandidos Publications style
Nishikawa H, Osaki Y, Komekado H, Sakamoto A, Saito S, Nishijima N, Nasu A, Arimoto A, Kita R, Kimura T, Kimura T, et al: Clinical significance of the FIB-4 index for non-B non-C hepatocellular carcinoma treated with surgical resection. Oncol Rep 33: 88-94, 2015.
APA
Nishikawa, H., Osaki, Y., Komekado, H., Sakamoto, A., Saito, S., Nishijima, N. ... Kimura, T. (2015). Clinical significance of the FIB-4 index for non-B non-C hepatocellular carcinoma treated with surgical resection. Oncology Reports, 33, 88-94. https://doi.org/10.3892/or.2014.3573
MLA
Nishikawa, H., Osaki, Y., Komekado, H., Sakamoto, A., Saito, S., Nishijima, N., Nasu, A., Arimoto, A., Kita, R., Kimura, T."Clinical significance of the FIB-4 index for non-B non-C hepatocellular carcinoma treated with surgical resection". Oncology Reports 33.1 (2015): 88-94.
Chicago
Nishikawa, H., Osaki, Y., Komekado, H., Sakamoto, A., Saito, S., Nishijima, N., Nasu, A., Arimoto, A., Kita, R., Kimura, T."Clinical significance of the FIB-4 index for non-B non-C hepatocellular carcinoma treated with surgical resection". Oncology Reports 33, no. 1 (2015): 88-94. https://doi.org/10.3892/or.2014.3573
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