Overexpression of adenylate cyclase-associated protein 1 may predict brain metastasis in non-small cell lung cancer

Xie,Shuan-Shuan; Tan,Min; Lin,Hai-Yan; Xu,Lei; Shen,Chang-Xing; Yuan,Qing; Song,Xiao-Lian; Wang,Chang-Hui

doi:10.3892/or.2014.3577

January-2015 Volume 33 Issue 1

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January-2015 Volume 33 Issue 1

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Article

Overexpression of adenylate cyclase-associated protein 1 may predict brain metastasis in non-small cell lung cancer

Authors:
- Shuan-Shuan Xie
- Min Tan
- Hai-Yan Lin
- Lei Xu
- Chang-Xing Shen
- Qing Yuan
- Xiao-Lian Song
- Chang-Hui Wang
View Affiliations / Copyright

Affiliations: Department of Respiratory Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, P.R. China
Pages: 363-371
|
Published online on: October 30, 2014

https://doi.org/10.3892/or.2014.3577
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Abstract

This study was designed to establish a biomarker risk model for predicting brain metastasis (BM) in non-small cell lung cancer (NSCLC). The model comprises 120 cases of NSCLC that were treated and followed up for 4 years. The patients were divided into the BM (n=50) and non-BM (other visceral metastasis and those without recurrence) (n=70) groups. Immunohistochemical and western blot analyses were performed in metastatic tissues of NSCLC. Multivariate regression analysis was performed to correlate the immunoreactive cyclase-associated protein 1 (CAP1) signal with BM. Survival analyses were performed by using the Kaplan-Meier method. CAP1 protein content and immunoreactivity were significantly increased in BM specimens compared to other-metastatic specimens. The survival analysis revealed that CAP1 overexpression was significantly associated with survival (P<0.05). The ROC test suggested that the area under the curve was 73.33% (P<0.001; 95% CI, 63.5-83.2%). When P=0.466, the sensitivity and specificity reached 79.5 and 67.1%, respectively. These findings suggested that CAP1 is involved in the BM of NSCLC, and that elevated levels of CAP1 expression may indicate a poor prognosis for patients with BM. The CAP1 molecular model may be useful in the prediction of the risk of BM in NSCLC.

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1	Siegel R, Ward E, Brawley O and Jemal A: Cancer statistics: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin. 61:212–236. 2011. View Article : Google Scholar : PubMed/NCBI
2	Walling J: Chemotherapy for advanced non-small-cell lung cancer. Respir Med. 88:649–657. 1994. View Article : Google Scholar : PubMed/NCBI
3	Govindan R, Page N, Morgensztern D, et al: Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database. J Clin Oncol. 24:4539–4544. 2006. View Article : Google Scholar : PubMed/NCBI
4	Strauss GM, Herndon JE, Sherman DD, et al: Neoadjuvant chemotherapy and radiotherapy followed by surgery in stage IIIA non-small-cell carcinoma of the lung: report of a Cancer and Leukemia Group B phase II study. J Clin Oncol. 10:1237–1244. 1992.PubMed/NCBI
5	Albain KS, Rusch VW, Crowley JJ, et al: Concurrent cisplatin/etoposide plus chest radiotherapy followed by surgery for stages IIIA (N2) and IIIB non-small-cell lung cancer: mature results of Southwest Oncology Group phase II study 8805. J Clin Oncol. 13:1880–1892. 1995.PubMed/NCBI
6	Andre F, Grunenwald D, Pujol JL, et al: Patterns of relapse of N2 non-small-cell lung carcinoma patients treated with preoperative chemotherapy: should prophylactic cranial irradiation be reconsidered? Cancer. 91:2394–2400. 2001. View Article : Google Scholar : PubMed/NCBI
7	Carmichael J, Crane JM, Bunn PA, et al: Results of therapeutic cranial irradiation in small cell lung cancer. Int J Radiat Oncol Biol Phys. 14:455–459. 1998. View Article : Google Scholar
8	Cox JD, Stanley K, Petrovich Z, et al: Cranial irradiation in cancer of the lung of all cell types. JAMA. 245:469–472. 1981. View Article : Google Scholar : PubMed/NCBI
9	Arriagada R, Le Chevalier T, Borie F, et al: Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. J Natl Cancer Inst. 87:183–190. 1995. View Article : Google Scholar : PubMed/NCBI
10	Shaw EG, Su JQ, Eagan RT, et al: Prophylactic cranial irradiation in complete responders with small-cell lung cancer: analysis of the Mayo Clinic and North Central Cancer Treatment Group data bases. J Clin Oncol. 12:2327–2332. 1994.PubMed/NCBI
11	Langer CJ and Mehta MP: Current management of brain metastases, with a focus on systemic options. J Clin Oncol. 23:6207–6219. 2005. View Article : Google Scholar : PubMed/NCBI
12	Tan M, Song X, Zhang G, et al: Overexpression of adenylate cyclase-associated protein 1 is associated with metastasis of lung cancer. Oncol Rep. 30:1639–1644. 2013.PubMed/NCBI
13	Delattre JY, Krol G, Thaler HT and Posner JB: Distribution of brain metastases. Arch Neurol. 45:741–744. 1988. View Article : Google Scholar : PubMed/NCBI
14	Fedor-Chaiken M, Deschenes RJ and Broach JR: SRV2, a gene required for RAS activation of adenylate cyclase in yeast. Cell. 61:329–340. 1990. View Article : Google Scholar : PubMed/NCBI
15	Field J, Vojtek A, Ballester R, et al: Cloning and characterization of CAP, the S. cerevisiae gene encoding the 70 kd adenylyl cyclase-associated protein. Cell. 61:319–327. 1990. View Article : Google Scholar : PubMed/NCBI
16	Matviw H, Yu G and Young D: Identification of a human cDNA encoding a protein that is structurally and functionally related to the yeast adenylyl cyclase-associated CAP proteins. Mol Cell Biol. 12:5033–5040. 1992.PubMed/NCBI
17	Freeman NL, Chen Z, Horenstein J, Weber A and Field J: An actin monomer binding activity localizes to the carboxyl-terminal half of the Saccharomyces cerevisiae cyclase-associated protein. J Biol Chem. 270:5680–5685. 1995. View Article : Google Scholar : PubMed/NCBI
18	Moriyama K and Yahara I: Human CAP1 is a key factor in the recycling of cofilin and actin for rapid actin turnover. J Cell Sci. 115:1591–1601. 2002.PubMed/NCBI
19	Hubberstey AV and Mottillo EP: Cyclase-associated proteins: CAPacity for linking signal transduction and actin polymerization. FASEB J. 16:487–499. 2002. View Article : Google Scholar : PubMed/NCBI
20	Loisel TP, Boujemaa R, Pantaloni D and Carlier MF: Reconstitution of actin-based motility of Listeria and Shigella using pure proteins. Nature. 401:613–616. 1999. View Article : Google Scholar : PubMed/NCBI
21	Yamazaki K, Takamura M, Masugi Y, et al: Adenylate cyclase-associated protein 1 overexpressed in pancreatic cancers is involved in cancer cell motility. Lab Invest. 89:425–432. 2009. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Overexpression of adenylate cyclase-associated protein 1 may predict brain metastasis in non-small cell lung cancer

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