Overexpression of adenylate cyclase-associated protein 1 may predict brain metastasis in non-small cell lung cancer

  • Authors:
    • Shuan-Shuan Xie
    • Min Tan
    • Hai-Yan Lin
    • Lei Xu
    • Chang-Xing Shen
    • Qing Yuan
    • Xiao-Lian Song
    • Chang-Hui Wang
  • View Affiliations

  • Published online on: October 30, 2014     https://doi.org/10.3892/or.2014.3577
  • Pages: 363-371
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Abstract

This study was designed to establish a biomarker risk model for predicting brain metastasis (BM) in non-small cell lung cancer (NSCLC). The model comprises 120 cases of NSCLC that were treated and followed up for 4 years. The patients were divided into the BM (n=50) and non-BM (other visceral metastasis and those without recurrence) (n=70) groups. Immunohistochemical and western blot analyses were performed in metastatic tissues of NSCLC. Multivariate regression analysis was performed to correlate the immunoreactive cyclase-associated protein 1 (CAP1) signal with BM. Survival analyses were performed by using the Kaplan-Meier method. CAP1 protein content and immunoreactivity were significantly increased in BM specimens compared to other-metastatic specimens. The survival analysis revealed that CAP1 overexpression was significantly associated with survival (P<0.05). The ROC test suggested that the area under the curve was 73.33% (P<0.001; 95% CI, 63.5-83.2%). When P=0.466, the sensitivity and specificity reached 79.5 and 67.1%, respectively. These findings suggested that CAP1 is involved in the BM of NSCLC, and that elevated levels of CAP1 expression may indicate a poor prognosis for patients with BM. The CAP1 molecular model may be useful in the prediction of the risk of BM in NSCLC.
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January-2015
Volume 33 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Xie S, Tan M, Lin H, Xu L, Shen C, Yuan Q, Song X and Wang C: Overexpression of adenylate cyclase-associated protein 1 may predict brain metastasis in non-small cell lung cancer. Oncol Rep 33: 363-371, 2015
APA
Xie, S., Tan, M., Lin, H., Xu, L., Shen, C., Yuan, Q. ... Wang, C. (2015). Overexpression of adenylate cyclase-associated protein 1 may predict brain metastasis in non-small cell lung cancer. Oncology Reports, 33, 363-371. https://doi.org/10.3892/or.2014.3577
MLA
Xie, S., Tan, M., Lin, H., Xu, L., Shen, C., Yuan, Q., Song, X., Wang, C."Overexpression of adenylate cyclase-associated protein 1 may predict brain metastasis in non-small cell lung cancer". Oncology Reports 33.1 (2015): 363-371.
Chicago
Xie, S., Tan, M., Lin, H., Xu, L., Shen, C., Yuan, Q., Song, X., Wang, C."Overexpression of adenylate cyclase-associated protein 1 may predict brain metastasis in non-small cell lung cancer". Oncology Reports 33, no. 1 (2015): 363-371. https://doi.org/10.3892/or.2014.3577