CLC-3 channels in cancer (Review)

  • Authors:
    • Sen Hong
    • Miaomiao Bi
    • Lei Wang
    • Zhenhua Kang
    • Limian Ling
    • Chunyan Zhao
  • View Affiliations

  • Published online on: November 21, 2014     https://doi.org/10.3892/or.2014.3615
  • Pages: 507-514
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Abstract

Ion channels are involved in regulating cell proliferation and apoptosis (programed cell death). Since increased cellular proliferation and inhibition of apoptosis are characteristic features of tumorigenesis, targeting ion channels is a promising strategy for treating cancer. CLC-3 is a member of the voltage-gated chloride channel superfamily and is expressed in many cancer cells. In the plasma membrane, CLC-3 functions as a chloride channel and is associated with cell proliferation and apoptosis. CLC-3 is also located in intracellular compartments, contributing to their acidity, which increases sequestration of drugs and leads to chemotherapy drug resistance. In this review, we summarize the recent findings concerning the involvement of CLC-3 in cancer and explore its potential in cancer therapy.
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February-2015
Volume 33 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Hong S, Bi M, Wang L, Kang Z, Ling L and Zhao C: CLC-3 channels in cancer (Review). Oncol Rep 33: 507-514, 2015
APA
Hong, S., Bi, M., Wang, L., Kang, Z., Ling, L., & Zhao, C. (2015). CLC-3 channels in cancer (Review). Oncology Reports, 33, 507-514. https://doi.org/10.3892/or.2014.3615
MLA
Hong, S., Bi, M., Wang, L., Kang, Z., Ling, L., Zhao, C."CLC-3 channels in cancer (Review)". Oncology Reports 33.2 (2015): 507-514.
Chicago
Hong, S., Bi, M., Wang, L., Kang, Z., Ling, L., Zhao, C."CLC-3 channels in cancer (Review)". Oncology Reports 33, no. 2 (2015): 507-514. https://doi.org/10.3892/or.2014.3615