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Article

Kisspeptin-10 inhibits the migration of breast cancer cells by regulating epithelial-mesenchymal transition

  • Authors:
    • Guo-Qing Song
    • Yi Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Pancreas and Breast Surgery, Shengjing Hospital of China Medical University, Heping, Shenyang, Liaoning 110004, P.R. China
  • Pages: 669-674
    |
    Published online on: November 24, 2014
       https://doi.org/10.3892/or.2014.3619
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Abstract

Breast cancer is the leading cause of cancer-related death in women. Kisspeptin-10 (KP-10) is a shorter fragment of KISS1. In the present study, we demonstrated the antitumor effects of KP-10 on human breast cancer cell lines, MDA-MB-231 and MDA-MB-157, both in vitro and in vivo. KP-10 was observed to induce apoptosis and inhibit the mobility of MDA-MB-231 and MDA-MB-157 cells. Correspondingly, KP-10 suppressed tumor growth in established xenograft tumor models and improved the survival rate of tumor-bearing mice. The formation of intratumoral microvessels was inhibited following treatment with KP-10. Finally, we confirmed that KP-10 inhibited cell mobility via epithelial-mesenchymal transition (EMT). Overall, the present study demonstrated that KP-10 suppressed breast cancer and human umbilical vein endothelial cell (HUVEC) growth both in vivo and in vitro. KP-10 is a novel regulator of EMT in breast cancer cells. However, additional studies are needed to confirm these results in other cell types.
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Copy and paste a formatted citation
Spandidos Publications style
Song G and Zhao Y: Kisspeptin-10 inhibits the migration of breast cancer cells by regulating epithelial-mesenchymal transition. Oncol Rep 33: 669-674, 2015.
APA
Song, G., & Zhao, Y. (2015). Kisspeptin-10 inhibits the migration of breast cancer cells by regulating epithelial-mesenchymal transition. Oncology Reports, 33, 669-674. https://doi.org/10.3892/or.2014.3619
MLA
Song, G., Zhao, Y."Kisspeptin-10 inhibits the migration of breast cancer cells by regulating epithelial-mesenchymal transition". Oncology Reports 33.2 (2015): 669-674.
Chicago
Song, G., Zhao, Y."Kisspeptin-10 inhibits the migration of breast cancer cells by regulating epithelial-mesenchymal transition". Oncology Reports 33, no. 2 (2015): 669-674. https://doi.org/10.3892/or.2014.3619
Copy and paste a formatted citation
x
Spandidos Publications style
Song G and Zhao Y: Kisspeptin-10 inhibits the migration of breast cancer cells by regulating epithelial-mesenchymal transition. Oncol Rep 33: 669-674, 2015.
APA
Song, G., & Zhao, Y. (2015). Kisspeptin-10 inhibits the migration of breast cancer cells by regulating epithelial-mesenchymal transition. Oncology Reports, 33, 669-674. https://doi.org/10.3892/or.2014.3619
MLA
Song, G., Zhao, Y."Kisspeptin-10 inhibits the migration of breast cancer cells by regulating epithelial-mesenchymal transition". Oncology Reports 33.2 (2015): 669-674.
Chicago
Song, G., Zhao, Y."Kisspeptin-10 inhibits the migration of breast cancer cells by regulating epithelial-mesenchymal transition". Oncology Reports 33, no. 2 (2015): 669-674. https://doi.org/10.3892/or.2014.3619
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