Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
February-2015 Volume 33 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2015 Volume 33 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

MLLT10 and IL3 rearrangement together with a complex four-way translocation and trisomy 4 in a patient with early T-cell precursor acute lymphoblastic leukemia: A case report

  • Authors:
    • Moneeb A.K. Othman
    • Joana B. Melo
    • Isabel M. Carreira
    • Martina Rincic
    • Eyad Alhourani
    • Kathleen Wilhelm
    • Bernd Gruhn
    • Anita Glaser
    • Thomas Liehr
  • View Affiliations / Copyright

    Affiliations: Jena University Hospital, Friedrich Schiller University, Institute of Human Genetics, Jena, Germany, Laboratory of Cytogenetics and Genomics, Faculty of Medicine, University of Coimbra, Coimbra, Portugal, Department of Pediatrics (Oncology and Hematology), Jena University Hospital, Friedrich Schiller University, Jena, Germany
  • Pages: 625-630
    |
    Published online on: November 25, 2014
       https://doi.org/10.3892/or.2014.3624
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cytogenetic classification of acute lymphoblastic leukemia (ALL) is primarily based on numerical and structural chromosomal abnormalities. In T-cell ALL (T-ALL), chromosomal rearrangements are identified in up to 70% of the patients while the remaining patients show a normal karyotype. In the present study, a 16-year-old male was diagnosed with T-precursor cell ALL and a normal karyotype after standard GTG-banding, was studied retrospectively (>10 years after diagnosis) in frame of a research project by molecular approaches. In addition to molecular cytogenetics, multiplex ligation-dependent probe amplification (MLPA) and high resolution array-comparative genomic hybridization (aCGH) were also applied. Thus, the following yet unrecognized balanced chromosomal aberrations were detected: der(3)t(3;5)(p23;q31.1), der(5)t(3;5)(p23;q35.3), der(5)t(5;10)(q31.1;p12.3) and der(10)t(5;10)(q35.3;p12.3). The oncogene MLLT10 was involved in this rearrangement as was the IL3 gene; in addition, trisomy 4 was present. All of these clonal aberrations were found in 40% of the cells. Even if this complex karyotype would have been identified at the time of diagnosis, most likely no other protocol of anticancer therapy (ALL-BFM 95) would have been applied. Three months after the end of a successful 2-year treatment, the patient suffered from isolated bone marrow relapse and died of sepsis during ALL-REZ-BFM protocol treatment.
View Figures

Figure 1

View References

1 

Han X and Bueso-Ramos CE: Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias. Am J Clin Pathol. 127:528–544. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Moorman AV, Richards SM, Martineau M, et al: Outcome heterogeneity in childhood high-hyperdiploid acute lymphoblastic leukemia. Blood. 102:2756–2762. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Chilton L, Buck G, Harrison CJ, et al: High hyperdiploidy among adolescents and adults with acute lymphoblastic leukaemia (ALL): cytogenetic features, clinical characteristics and outcome. Leukemia. 28:1511–1518. 2014. View Article : Google Scholar

4 

Heerema NA, Sather HN, Sensel MG, et al: Prognostic impact of trisomies of chromosomes 10, 17, and 5 among children with acute lymphoblastic leukemia and high hyperdiploidy (>50 chromosomes). J Clin Oncol. 18:1876–1887. 2000.PubMed/NCBI

5 

Paulsson K, Forestier E, Andersen MK, et al: High modal number and triple trisomies are highly correlated favorable factors in childhood B-cell precursor high hyperdiploid acute lymphoblastic leukemia treated according to the NOPHO ALL 1992/2000 protocols. Haematologica. 98:1424–1432. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Gupta V and Chun K: Trisomy 4 as the sole cytogenetic abnormality in a patient with T-cell acute lymphoblastic leukemia. Cancer Genet Cytogenet. 152:158–162. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Paulsson K, Panagopoulos I, Knuutila S, et al: Formation of trisomies and their parental origin in hyperdiploid childhood acute lymphoblastic leukemia. Blood. 102:3010–3015. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Gruszka-Westwood AM, Horsley SW, Martinez-Ramirez A, et al: Comparative expressed sequence hybridization studies of high-hyperdiploid childhood acute lymphoblastic leukemia. Genes Chromosomes Cancer. 41:191–202. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Kebriaei P, Anastasi J and Larson RA: Acute lymphoblastic leukaemia: diagnosis and classification. Best Pract Res Clin Haematol. 15:597–621. 2002. View Article : Google Scholar

10 

Cauwelier B, Dastugue N, Cools J, et al: Molecular cytogenetic study of 126 unselected T-ALL cases reveals high incidence of TCRbeta locus rearrangements and putative new T-cell oncogenes. Leukemia. 20:1238–1244. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Inaba H, Greaves M and Mullighan CG: Acute lymphoblastic leukaemia. Lancet. 381:1943–1955. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Berger R, Dastugue N, Busson M, et al: t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Français de Cytogénétique Hématologique (GFCH). Leukemia. 17:1851–1857. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Borel C, Dastugue N, Cances-Lauwers V, et al: PICALM-MLLT10 acute myeloid leukemia: a French cohort of 18 patients. Leuk Res. 36:1365–1369. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Brandimarte L, Pierini V, Di Giacomo D, et al: New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia. Blood. 121:5064–5067. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Coustan-Smith E, Mullighan CG, Onciu M, et al: Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia. Lancet Oncol. 10:147–156. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Inukai T, Kiyokawa N, Campana D, et al: Clinical significance of early T-cell precursor acute lymphoblastic leukaemia: results of the Tokyo Children’s Cancer Study Group Study L99-15. Br J Haematol. 156:358–365. 2012. View Article : Google Scholar

17 

Zhang J, Ding L, Holmfeldt L, et al: The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature. 481:157–163. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Claussen U, Michel S, Mühlig P, et al: Demystifying chromosome preparation and the implications for the concept of chromosome condensation during mitosis. Cytogenet Genome Res. 98:136–146. 2002. View Article : Google Scholar

19 

Liehr T and Claussen U: Current developments in human molecular cytogenetic techniques. Curr Mol Med. 2:283–297. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Liehr T, Heller A, Starke H, et al: Microdissection based high resolution multicolor banding for all 24 human chromosomes. Int J Mol Med. 9:335–339. 2002.PubMed/NCBI

21 

Weise A, Heller A, Starke H, et al: Multitude multicolor chromosome banding (mMCB) - a comprehensive one-step multicolor FISH banding method. Cytogenet Genome Res. 103:34–39. 2003. View Article : Google Scholar

22 

Weise A, Mrasek K, Fickelscher I, et al: Molecular definition of high-resolution multicolor banding probes: first within the human DNA sequence anchored FISH banding probe set. J Histochem Cytochem. 56:487–493. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Bernard OA, Romana SP, Poirel H and Berger R: Molecular cytogenetics of t(12;21) (p13;q22). Leuk Lymphoma. 23:459–465. 1996. View Article : Google Scholar : PubMed/NCBI

24 

Usvasalo A, Räty R, Harila-Saari A, et al: Acute lymphoblastic leukemias with normal karyotypes are not without genomic aberrations. Cancer Genet Cytogenet. 192:10–17. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Mkrtchyan H, Glaser M, Gross M, et al: Multicolor-FISH applied to resolve complex chromosomal changes in a case of T-ALL (FAB L2). Cytogenet Genome Res. 114:270–273. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Bains A, Lu G, Yao H, et al: Molecular and clinicopathologic characterization of AML with isolated trisomy 4. Am J Clin Pathol. 137:387–394. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Moreau P, Talmant P, Milpied N, et al: Trisomy 4 associated with acute lymphocytic leukaemia. Br J Haematol. 78:5761991. View Article : Google Scholar : PubMed/NCBI

28 

Yip SF, Wan TS, Chan LC and Chan GC: Trisomy 4 as sole karyotypic abnormality in acute lymphoblastic leukemia: different clinical features and treatment response between B and T phenotypes? Cancer Genet Cytogenet. 164:94–95. 2006. View Article : Google Scholar

29 

Steelman LS, Algate PA, Blalock WL, et al: Oncogenic effects of overexpression of the interleukin-3 receptor on hematopoietic cells. Leukemia. 10:528–542. 1996.PubMed/NCBI

30 

DiMartino JF, Ayton PM, Chen EH, et al: The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10. Blood. 99:3780–3785. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Asnafi V, Radford-Weiss I, Dastugue N, et al: CALM-AF10 is a common fusion transcript in T-ALL and is specific to the TCRgammadelta lineage. Blood. 102:1000–1006. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Coenen EA, Raimondi SC, Harbott J, et al: Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11q23/MLL-rearranged AML patients: results of an international study. Blood. 117:7102–7111. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Dreyling MH, Schrader K, Fonatsch C, et al: MLL and CALM are fused to AF10 in morphologically distinct subsets of acute leukemia with translocation t(10;11): both rearrangements are associated with a poor prognosis. Blood. 91:4662–4667. 1998.PubMed/NCBI

34 

Caudell D and Aplan PD: The role of CALM-AF10 gene fusion in acute leukemia. Leukemia. 22:678–685. 2008. View Article : Google Scholar

35 

Crescenzi B, La Starza R, Romoli S, et al: Submicroscopic deletions in 5q-associated malignancies. Haematologica. 89:281–285. 2004.PubMed/NCBI

36 

Kayser S, Zucknick M, Döhner K, et al: Monosomal karyotype in adult acute myeloid leukemia: prognostic impact and outcome after different treatment strategies. Blood. 119:551–558. 2012. View Article : Google Scholar

37 

Mangi MH and Newland AC: Interleukin-3 in hematology and oncology: current state of knowledge and future directions. Cytokines Cell Mol Ther. 5:87–95. 1999.PubMed/NCBI

38 

Gallego M, Coccé M, Felice M, et al: A new case of t(5;14) (q31;q32) in a pediatric acute lymphoblastic leukemia presenting with hypereosinophilia. Atlas Genet Cytogenet Oncol Haematol. 16:183–184. 2012.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Othman MA, Melo JB, Carreira IM, Rincic M, Alhourani E, Wilhelm K, Gruhn B, Glaser A and Liehr T: MLLT10 and IL3 rearrangement together with a complex four-way translocation and trisomy 4 in a patient with early T-cell precursor acute lymphoblastic leukemia: A case report. Oncol Rep 33: 625-630, 2015.
APA
Othman, M.A., Melo, J.B., Carreira, I.M., Rincic, M., Alhourani, E., Wilhelm, K. ... Liehr, T. (2015). MLLT10 and IL3 rearrangement together with a complex four-way translocation and trisomy 4 in a patient with early T-cell precursor acute lymphoblastic leukemia: A case report. Oncology Reports, 33, 625-630. https://doi.org/10.3892/or.2014.3624
MLA
Othman, M. A., Melo, J. B., Carreira, I. M., Rincic, M., Alhourani, E., Wilhelm, K., Gruhn, B., Glaser, A., Liehr, T."MLLT10 and IL3 rearrangement together with a complex four-way translocation and trisomy 4 in a patient with early T-cell precursor acute lymphoblastic leukemia: A case report". Oncology Reports 33.2 (2015): 625-630.
Chicago
Othman, M. A., Melo, J. B., Carreira, I. M., Rincic, M., Alhourani, E., Wilhelm, K., Gruhn, B., Glaser, A., Liehr, T."MLLT10 and IL3 rearrangement together with a complex four-way translocation and trisomy 4 in a patient with early T-cell precursor acute lymphoblastic leukemia: A case report". Oncology Reports 33, no. 2 (2015): 625-630. https://doi.org/10.3892/or.2014.3624
Copy and paste a formatted citation
x
Spandidos Publications style
Othman MA, Melo JB, Carreira IM, Rincic M, Alhourani E, Wilhelm K, Gruhn B, Glaser A and Liehr T: MLLT10 and IL3 rearrangement together with a complex four-way translocation and trisomy 4 in a patient with early T-cell precursor acute lymphoblastic leukemia: A case report. Oncol Rep 33: 625-630, 2015.
APA
Othman, M.A., Melo, J.B., Carreira, I.M., Rincic, M., Alhourani, E., Wilhelm, K. ... Liehr, T. (2015). MLLT10 and IL3 rearrangement together with a complex four-way translocation and trisomy 4 in a patient with early T-cell precursor acute lymphoblastic leukemia: A case report. Oncology Reports, 33, 625-630. https://doi.org/10.3892/or.2014.3624
MLA
Othman, M. A., Melo, J. B., Carreira, I. M., Rincic, M., Alhourani, E., Wilhelm, K., Gruhn, B., Glaser, A., Liehr, T."MLLT10 and IL3 rearrangement together with a complex four-way translocation and trisomy 4 in a patient with early T-cell precursor acute lymphoblastic leukemia: A case report". Oncology Reports 33.2 (2015): 625-630.
Chicago
Othman, M. A., Melo, J. B., Carreira, I. M., Rincic, M., Alhourani, E., Wilhelm, K., Gruhn, B., Glaser, A., Liehr, T."MLLT10 and IL3 rearrangement together with a complex four-way translocation and trisomy 4 in a patient with early T-cell precursor acute lymphoblastic leukemia: A case report". Oncology Reports 33, no. 2 (2015): 625-630. https://doi.org/10.3892/or.2014.3624
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team