Epithelial-mesenchymal transition‑associated microRNAs in colorectal cancer and drug-targeted therapies (Review)

  • Authors:
    • Danjuan Jin
    • Yantian Fang
    • Zhengyang Li
    • Zongyou Chen
    • Jianbin Xiang
  • View Affiliations

  • Published online on: December 1, 2014     https://doi.org/10.3892/or.2014.3638
  • Pages: 515-525
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Abstract

Colorectal cancer (CRC) is one of the most common malignancies, and the third leading cause of cancer‑associated mortality worldwide. Therefore, the identification of effective targets at the early stages of cancer invasion and metastasis, and new tumor markers for early diagnosis and individualized treatment is imperative for CRC. Epithelial‑mesenchymal transition (EMT) refers to the phenomenon of the transformation of epithelial cells to mesenchymal cells in specific physiological and/or pathological circumstances. Evidence suggests that EMT plays an important role in in situ infiltration and distant metastasis of many types of cancer, including CRC. Recent findings showed that microRNA expression is important in regulating the EMT process. This review aimed to summarize EMT-associated specific miRNA molecules in CRC, with particular emphasis on clinical targets for effective treatment of this lethal disease.
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February-2015
Volume 33 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Jin D, Fang Y, Li Z, Chen Z and Xiang J: Epithelial-mesenchymal transition‑associated microRNAs in colorectal cancer and drug-targeted therapies (Review). Oncol Rep 33: 515-525, 2015
APA
Jin, D., Fang, Y., Li, Z., Chen, Z., & Xiang, J. (2015). Epithelial-mesenchymal transition‑associated microRNAs in colorectal cancer and drug-targeted therapies (Review). Oncology Reports, 33, 515-525. https://doi.org/10.3892/or.2014.3638
MLA
Jin, D., Fang, Y., Li, Z., Chen, Z., Xiang, J."Epithelial-mesenchymal transition‑associated microRNAs in colorectal cancer and drug-targeted therapies (Review)". Oncology Reports 33.2 (2015): 515-525.
Chicago
Jin, D., Fang, Y., Li, Z., Chen, Z., Xiang, J."Epithelial-mesenchymal transition‑associated microRNAs in colorectal cancer and drug-targeted therapies (Review)". Oncology Reports 33, no. 2 (2015): 515-525. https://doi.org/10.3892/or.2014.3638