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Article

miR-200a suppresses cell growth and migration by targeting MACC1 and predicts prognosis in hepatocellular carcinoma

  • Authors:
    • Jiye Feng
    • Jinbo Wang
    • Mingliang Chen
    • Gun Chen
    • Zongyang Wu
    • Liping Ying
    • Qifeng Zhuo
    • Jianlei Zhang
    • Weilin Wang
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, Ningbo Yinzhou People's Hospital (Yinzhou Hospital Affiliated to Medical School of Ningbo University), Ningbo, Zhejiang 315040, P.R. China, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China
  • Pages: 713-720
    |
    Published online on: December 2, 2014
       https://doi.org/10.3892/or.2014.3642
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Abstract

miR-200a suppresses tumor development and progression; however, its role in tumor growth and metastasis of hepatocellular carcinoma (HCC) and the underlying mechanism have not been elucidated. In the present study, we identified that miR-200a was markedly downregulated in HCC and exerted suppressive effects on tumor cell growth and metastasis. We identified that miR-200a suppressed tumor growth and metastasis by directly targeting MACC1. In addition, HCC patients with low miR-200a expression had significantly worse prognosis than those with high expression of miR-200a. These findings suggest that miR-200a may be recognized as a novel potential biomarker to predict the survival of patients with HCCs following liver transplantation.
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Copy and paste a formatted citation
Spandidos Publications style
Feng J, Wang J, Chen M, Chen G, Wu Z, Ying L, Zhuo Q, Zhang J and Wang W: miR-200a suppresses cell growth and migration by targeting MACC1 and predicts prognosis in hepatocellular carcinoma. Oncol Rep 33: 713-720, 2015.
APA
Feng, J., Wang, J., Chen, M., Chen, G., Wu, Z., Ying, L. ... Wang, W. (2015). miR-200a suppresses cell growth and migration by targeting MACC1 and predicts prognosis in hepatocellular carcinoma. Oncology Reports, 33, 713-720. https://doi.org/10.3892/or.2014.3642
MLA
Feng, J., Wang, J., Chen, M., Chen, G., Wu, Z., Ying, L., Zhuo, Q., Zhang, J., Wang, W."miR-200a suppresses cell growth and migration by targeting MACC1 and predicts prognosis in hepatocellular carcinoma". Oncology Reports 33.2 (2015): 713-720.
Chicago
Feng, J., Wang, J., Chen, M., Chen, G., Wu, Z., Ying, L., Zhuo, Q., Zhang, J., Wang, W."miR-200a suppresses cell growth and migration by targeting MACC1 and predicts prognosis in hepatocellular carcinoma". Oncology Reports 33, no. 2 (2015): 713-720. https://doi.org/10.3892/or.2014.3642
Copy and paste a formatted citation
x
Spandidos Publications style
Feng J, Wang J, Chen M, Chen G, Wu Z, Ying L, Zhuo Q, Zhang J and Wang W: miR-200a suppresses cell growth and migration by targeting MACC1 and predicts prognosis in hepatocellular carcinoma. Oncol Rep 33: 713-720, 2015.
APA
Feng, J., Wang, J., Chen, M., Chen, G., Wu, Z., Ying, L. ... Wang, W. (2015). miR-200a suppresses cell growth and migration by targeting MACC1 and predicts prognosis in hepatocellular carcinoma. Oncology Reports, 33, 713-720. https://doi.org/10.3892/or.2014.3642
MLA
Feng, J., Wang, J., Chen, M., Chen, G., Wu, Z., Ying, L., Zhuo, Q., Zhang, J., Wang, W."miR-200a suppresses cell growth and migration by targeting MACC1 and predicts prognosis in hepatocellular carcinoma". Oncology Reports 33.2 (2015): 713-720.
Chicago
Feng, J., Wang, J., Chen, M., Chen, G., Wu, Z., Ying, L., Zhuo, Q., Zhang, J., Wang, W."miR-200a suppresses cell growth and migration by targeting MACC1 and predicts prognosis in hepatocellular carcinoma". Oncology Reports 33, no. 2 (2015): 713-720. https://doi.org/10.3892/or.2014.3642
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