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Article

Efficacy of dual-functional liposomes containing paclitaxel for treatment of lung cancer

Retraction in: /10.3892/or.2017.6006
  • Authors:
    • Rong-Hua Wang
    • Hong-Mei Cao
    • Zhi-Ju Tian
    • Bo Jin
    • Qing Wang
    • Hong Ma
    • Jing Wu
  • View Affiliations / Copyright

    Affiliations: Department of Cardiothoracic Surgery, People’s Hospital of Zhangqiu, Zhangqiu, Shandong 250200, P.R. China, Pharmacy Intravenous Admixture Services, People’s Hospital of Zhangqiu, Zhangqiu, Shandong 250200, P.R. China, Department of Orthopedic Surgery, People's Hospital of Zhangqiu, Zhangqiu, Shandong 250200, P.R. China, Department of Oral Pendulum Medicine, People's Hospital of Zhangqiu, Zhangqiu, Shandong 250200, P.R. China, Pharmacy Intravenous Admixture Services, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China
  • Pages: 783-791
    |
    Published online on: December 2, 2014
       https://doi.org/10.3892/or.2014.3644
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Abstract

This study was mainly focused on the development of a dual-ligand liposomal delivery system for targeting the delivery of paclitaxel (PTX) to lung cancer. The specific ligand peptide HAIYPRH (T7) and the cationic cell-penetrating peptide TAT were connected with phospholipid via a polyethylene glycol (PEG) spacer to prepare the dual-ligand liposomes (T7/TAT-LP-PTX). Physicochemical characterizations of T7/TAT-LP-PTX, such as particle size, ζ potential, morphology, encapsulation efficiency, and in vitro PTX release, were also evaluated. In the cellular uptake study, the T7/TAT-LP endocytosed by the A549 cells was 2.26‑, 3.48‑ and 8.56‑fold higher than TAT-LP, T7-LP and LP, respectively. The IC50 values of TAT-LP-PTX, T7-LP-PTX and LP-PTX were much higher than those of T7/TAT-LP-PTX, respectively. The homing specificity of T7/TAT-LP was evaluated on the tumor spheroids, which revealed that T7/TAT-LP was more efficaciously internalized in tumor cells than TAT-LP, T7-LP and LP, respectively. Compared to LP, TAT-LP and T7-LP, T7/TAT-LP showed the strongest cell uptake property, and the highest accumulation ability in tumor spheroids in vitro. In the in vivo study, the T7/TAT-LP-PTX exhibited the best inhibitory effect of tumor growth for A549-bearing mice. Collectively, these results suggested that T7/TAT-LP-PTX is a promising drug delivery system for the treatment of lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Wang R, Cao H, Tian Z, Jin B, Wang Q, Ma H and Wu J: Efficacy of dual-functional liposomes containing paclitaxel for treatment of lung cancer Retraction in /10.3892/or.2017.6006. Oncol Rep 33: 783-791, 2015.
APA
Wang, R., Cao, H., Tian, Z., Jin, B., Wang, Q., Ma, H., & Wu, J. (2015). Efficacy of dual-functional liposomes containing paclitaxel for treatment of lung cancer Retraction in /10.3892/or.2017.6006. Oncology Reports, 33, 783-791. https://doi.org/10.3892/or.2014.3644
MLA
Wang, R., Cao, H., Tian, Z., Jin, B., Wang, Q., Ma, H., Wu, J."Efficacy of dual-functional liposomes containing paclitaxel for treatment of lung cancer Retraction in /10.3892/or.2017.6006". Oncology Reports 33.2 (2015): 783-791.
Chicago
Wang, R., Cao, H., Tian, Z., Jin, B., Wang, Q., Ma, H., Wu, J."Efficacy of dual-functional liposomes containing paclitaxel for treatment of lung cancer Retraction in /10.3892/or.2017.6006". Oncology Reports 33, no. 2 (2015): 783-791. https://doi.org/10.3892/or.2014.3644
Copy and paste a formatted citation
x
Spandidos Publications style
Wang R, Cao H, Tian Z, Jin B, Wang Q, Ma H and Wu J: Efficacy of dual-functional liposomes containing paclitaxel for treatment of lung cancer Retraction in /10.3892/or.2017.6006. Oncol Rep 33: 783-791, 2015.
APA
Wang, R., Cao, H., Tian, Z., Jin, B., Wang, Q., Ma, H., & Wu, J. (2015). Efficacy of dual-functional liposomes containing paclitaxel for treatment of lung cancer Retraction in /10.3892/or.2017.6006. Oncology Reports, 33, 783-791. https://doi.org/10.3892/or.2014.3644
MLA
Wang, R., Cao, H., Tian, Z., Jin, B., Wang, Q., Ma, H., Wu, J."Efficacy of dual-functional liposomes containing paclitaxel for treatment of lung cancer Retraction in /10.3892/or.2017.6006". Oncology Reports 33.2 (2015): 783-791.
Chicago
Wang, R., Cao, H., Tian, Z., Jin, B., Wang, Q., Ma, H., Wu, J."Efficacy of dual-functional liposomes containing paclitaxel for treatment of lung cancer Retraction in /10.3892/or.2017.6006". Oncology Reports 33, no. 2 (2015): 783-791. https://doi.org/10.3892/or.2014.3644
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