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Article

Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis

  • Authors:
    • Mingbo Cai
    • Zhenhua Hu
    • Juanjuan Liu
    • Jian Gao
    • Mingzi Tan
    • Danye Zhang
    • Liancheng Zhu
    • Shuice Liu
    • Rui Hou
    • Bei Lin
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University, Heping, Shenyang, Liaoning 110004, P.R. China
  • Pages: 685-692
    |
    Published online on: December 5, 2014
       https://doi.org/10.3892/or.2014.3649
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Abstract

Human MOF (hMOF) is a major acetylase of human H4K16 involved in the regulation of physiological and pathological processes. We investigated the expression of hMOF in different ovarian tissues and its correlation with ovarian cancer prognosis. Reverse transcription PCR and western blot analysis were used to detect hMOF mRNA and protein expression, respectively, in different ovarian tissues. Immunohistochemistry was also performed to detect hMOF expression in different ovarian tissues, including ovarian epithelial cancer, borderline tumor, benign tumor and normal ovarian tissues. In addition, the relationships between hMOF expression and clinicopathological ovarian cancer data were analyzed. The Cox proportional-hazards regression model was used to analyze the factors associated with ovarian cancer prognosis. To analyze the effects of hMOF expression on ovarian cancer prognosis, a survival curve was plotted from the follow-up data of 77 patients with ovarian cancer. Compared with normal ovarian tissues, hMOF mRNA and protein expression was significantly decreased in ovarian epithelial cancer tissues. The proportions of high hMOF expression in normal and benign ovarian epithelial tumor tissues, were much higher than those in ovarian epithelial cancer tissues. Furthermore, hMOF protein expression was closely associated with the ovarian cancer stage. The expression of hMOF protein was determined as an independent risk factor influencing ovarian cancer prognosis. Patients with high hMOF levels showed improved survival than those with low hMOF levels. hMOF mRNA and protein expression decreased in ovarian epithelial cancer, thus the hMOF protein potentially serves as a new clinical marker of ovarian cancer prognosis.
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1 

Strahl BD and Allis CD: The language of covalent histone modifications. Nature. 403:41–45. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Carrozza MJ, Utley RT, Workman JL and Côté J: The diverse functions of histone acetyltransferase complexes. Trends Genet. 19:321–329. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Yamada T, Mizuno K, Hirota K, et al: Roles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot. EMBO J. 23:1792–1803. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Eberharter A and Becker PB: Histone acetylation: a switch between repressive and permissive chromatin. Second in review series on chromatin dynamics. EMBO Rep. 3:224–229. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Yang XJ: The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. Nucleic Acids Res. 32:959–976. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Saha RN and Pahan K: HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis. Cell Death Differ. 13:539–550. 2006. View Article : Google Scholar

7 

Ito K, Charron CE and Adcock IM: Impact of protein acetylation in inflammatory lung diseases. Pharmacol Ther. 116:249–265. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Gayther SA, Batley SJ, Linger L, et al: Mutations truncating the EP300 acetylase in human cancers. Nat Genet. 24:300–303. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Halkidou K, Gaughan L, Cook S, Leung HY, Neal DE and Robson CN: Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer. Prostate. 59:177–189. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Yang XJ and Seto E: Lysine acetylation: codified crosstalk with other posttranslational modifications. Mol Cell. 31:449–461. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Hilfiker A, Hilfiker-Kleiner D, Pannuti A and Lucchesi JC: mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila. EMBO J. 16:2054–2060. 1997. View Article : Google Scholar : PubMed/NCBI

12 

Akhtar A and Becker PB: Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila. Mol Cell. 5:367–375. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Thomas T, Dixon MP, Kueh AJ and Voss AK: Mof (MYST1 or KAT8) is essential for progression of embryonic development past the blastocyst stage and required for normal chromatin architecture. Mol Cell Biol. 28:5093–5105. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Li X, Li L, Pandey R, et al: The histone acetyltransferase MOF is a key regulator of the embryonic stem cell core transcriptional network. Cell Stem Cell. 11:163–178. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Smith ER, Cayrou C, Huang R, Lane WS, Côté J and Lucchesi JC: A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. Mol Cell Biol. 25:9175–9188. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Cai Y, Jin J, Swanson SK, et al: Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. J Biol Chem. 285:4268–4272. 2010. View Article : Google Scholar :

17 

Taipale M, Rea S, Richter K, et al: hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells. Mol Cell Biol. 25:6798–6810. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Rea S, Xouri G and Akhtar A: Males absent on the first (MOF): from flies to humans. Oncogene. 26:5385–5394. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Pfister S, Rea S, Taipale M, et al: The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma. Int J Cancer. 122:1207–1213. 2008. View Article : Google Scholar

20 

Wang Y, Zhang R, Wu D, et al: Epigenetic change in kidney tumor: downregulation of histone acetyltransferase MYST1 in human renal cell carcinoma. J Exp Clin Cancer Res. 32:82013. View Article : Google Scholar : PubMed/NCBI

21 

Zhao L, Wang DL, Liu Y, Chen S and Sun FL: Histone acetyltransferase hMOF promotes S phase entry and tumorigenesis in lung cancer. Cell Signal. 25:1689–1698. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Liu N, Zhang R, Zhao X, et al: A potential diagnostic marker for ovarian cancer: Involvement of the histone acetyltransferase, human males absent on the first. Oncol Lett. 6:393–400. 2013.PubMed/NCBI

23 

Cao L, Zhu L, Yang J, et al: Correlation of low expression of hMOF with clinicopathological features of colorectal carcinoma, gastric cancer and renal cell carcinoma. Int J Oncol. 44:1207–1214. 2014.PubMed/NCBI

24 

Gupta A, Sharma GG, Young CS, et al: Involvement of human MOF in ATM function. Mol Cell Biol. 25:5292–5305. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Mendjan S, Taipale M, Kind J, et al: Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila. Mol Cell. 21:811–823. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Sykes SM, Mellert HS, Holbert MA, et al: Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell. 24:841–851. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Hajji N, Wallenborg K, Vlachos P, Füllgrabe J, Hermanson O and Joseph B: Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide. Oncogene. 29:2192–2204. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cai M, Hu Z, Liu J, Gao J, Tan M, Zhang D, Zhu L, Liu S, Hou R, Lin B, Lin B, et al: Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis. Oncol Rep 33: 685-692, 2015.
APA
Cai, M., Hu, Z., Liu, J., Gao, J., Tan, M., Zhang, D. ... Lin, B. (2015). Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis. Oncology Reports, 33, 685-692. https://doi.org/10.3892/or.2014.3649
MLA
Cai, M., Hu, Z., Liu, J., Gao, J., Tan, M., Zhang, D., Zhu, L., Liu, S., Hou, R., Lin, B."Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis". Oncology Reports 33.2 (2015): 685-692.
Chicago
Cai, M., Hu, Z., Liu, J., Gao, J., Tan, M., Zhang, D., Zhu, L., Liu, S., Hou, R., Lin, B."Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis". Oncology Reports 33, no. 2 (2015): 685-692. https://doi.org/10.3892/or.2014.3649
Copy and paste a formatted citation
x
Spandidos Publications style
Cai M, Hu Z, Liu J, Gao J, Tan M, Zhang D, Zhu L, Liu S, Hou R, Lin B, Lin B, et al: Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis. Oncol Rep 33: 685-692, 2015.
APA
Cai, M., Hu, Z., Liu, J., Gao, J., Tan, M., Zhang, D. ... Lin, B. (2015). Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis. Oncology Reports, 33, 685-692. https://doi.org/10.3892/or.2014.3649
MLA
Cai, M., Hu, Z., Liu, J., Gao, J., Tan, M., Zhang, D., Zhu, L., Liu, S., Hou, R., Lin, B."Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis". Oncology Reports 33.2 (2015): 685-692.
Chicago
Cai, M., Hu, Z., Liu, J., Gao, J., Tan, M., Zhang, D., Zhu, L., Liu, S., Hou, R., Lin, B."Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis". Oncology Reports 33, no. 2 (2015): 685-692. https://doi.org/10.3892/or.2014.3649
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