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Article

Synthesized tetrahydroisoquinoline alkaloid exerts anticancer effects at least in part by suppressing NF‑κB‑regulated proteins in A549 human lung cancer cells

  • Authors:
    • Won Sup Lee
    • Jeong Won Yun
    • Arulkumar Nagappan
    • Jing Nan Lu
    • Min Jeong Kim
    • Jeong-Hee Lee
    • Dong Hoon Kim
    • Yung Hyun Choi
    • Hye Jung Kim
    • Ki Churl Chang
    • Jin-Myung Jung

  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 660-702, Republic of Korea, Department of Pathology, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 660-702, Republic of Korea, Department of Emergency Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 660-702, Republic of Korea, Department of Pharmacology, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 660-702, Republic of Korea, Department of Biochemistry, Dongeui University College of Oriental Medicine and Department of Biomaterial Control (BK21 program), Dongeui University Graduate School, Busan 614-052, Republic of Korea, Department of Neurosurgery, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 660-702, Republic of Korea
  • Pages: 1141-1146
    |
    Published online on: December 8, 2014
       https://doi.org/10.3892/or.2014.3658
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Abstract

CKD‑712, a newly synthesized tetrahydroisoquinoline (THI) and an enantiomer (S form) of YS 49 (a derivative of higenamine) has been reported to suppress nuclear factor-κB (NF-κB) activity in normal cells. In the present study, we investigated the anticancer effects of THI at a low concentration where CKD-712 did not induce cell death in normal cells. At the range of concentrations used, CKD-712 induced cell growth arrest, and inhibited the invasion and motility of A549 cells as determined by cell cycle analysis, a Matrigel‑coated chamber assay, and a wound‑healing assay, respectively. CKD-712 suppressed MMP-9, but not MMP-2 and other NF-κB-regulated proteins involved in cancer metastasis such as VEGF. Moreover, CKD-712 induced cell cycle arrest at G2M phase by suppressing cyclin A, cyclin B and CDK-1 expression. Taken together, these data suggested that CKD-712 may exert anticancer effects by suppressing NF-κB pathways and inducing cell cycle arrest at G2M phase.
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Copy and paste a formatted citation
Spandidos Publications style
Lee WS, Yun JW, Nagappan A, Lu JN, Kim MJ, Lee J, Kim DH, Choi YH, Kim HJ, Chang KC, Chang KC, et al: Synthesized tetrahydroisoquinoline alkaloid exerts anticancer effects at least in part by suppressing NF‑κB‑regulated proteins in A549 human lung cancer cells. Oncol Rep 33: 1141-1146, 2015.
APA
Lee, W.S., Yun, J.W., Nagappan, A., Lu, J.N., Kim, M.J., Lee, J. ... Jung, J. (2015). Synthesized tetrahydroisoquinoline alkaloid exerts anticancer effects at least in part by suppressing NF‑κB‑regulated proteins in A549 human lung cancer cells. Oncology Reports, 33, 1141-1146. https://doi.org/10.3892/or.2014.3658
MLA
Lee, W. S., Yun, J. W., Nagappan, A., Lu, J. N., Kim, M. J., Lee, J., Kim, D. H., Choi, Y. H., Kim, H. J., Chang, K. C., Jung, J."Synthesized tetrahydroisoquinoline alkaloid exerts anticancer effects at least in part by suppressing NF‑κB‑regulated proteins in A549 human lung cancer cells". Oncology Reports 33.3 (2015): 1141-1146.
Chicago
Lee, W. S., Yun, J. W., Nagappan, A., Lu, J. N., Kim, M. J., Lee, J., Kim, D. H., Choi, Y. H., Kim, H. J., Chang, K. C., Jung, J."Synthesized tetrahydroisoquinoline alkaloid exerts anticancer effects at least in part by suppressing NF‑κB‑regulated proteins in A549 human lung cancer cells". Oncology Reports 33, no. 3 (2015): 1141-1146. https://doi.org/10.3892/or.2014.3658
Copy and paste a formatted citation
x
Spandidos Publications style
Lee WS, Yun JW, Nagappan A, Lu JN, Kim MJ, Lee J, Kim DH, Choi YH, Kim HJ, Chang KC, Chang KC, et al: Synthesized tetrahydroisoquinoline alkaloid exerts anticancer effects at least in part by suppressing NF‑κB‑regulated proteins in A549 human lung cancer cells. Oncol Rep 33: 1141-1146, 2015.
APA
Lee, W.S., Yun, J.W., Nagappan, A., Lu, J.N., Kim, M.J., Lee, J. ... Jung, J. (2015). Synthesized tetrahydroisoquinoline alkaloid exerts anticancer effects at least in part by suppressing NF‑κB‑regulated proteins in A549 human lung cancer cells. Oncology Reports, 33, 1141-1146. https://doi.org/10.3892/or.2014.3658
MLA
Lee, W. S., Yun, J. W., Nagappan, A., Lu, J. N., Kim, M. J., Lee, J., Kim, D. H., Choi, Y. H., Kim, H. J., Chang, K. C., Jung, J."Synthesized tetrahydroisoquinoline alkaloid exerts anticancer effects at least in part by suppressing NF‑κB‑regulated proteins in A549 human lung cancer cells". Oncology Reports 33.3 (2015): 1141-1146.
Chicago
Lee, W. S., Yun, J. W., Nagappan, A., Lu, J. N., Kim, M. J., Lee, J., Kim, D. H., Choi, Y. H., Kim, H. J., Chang, K. C., Jung, J."Synthesized tetrahydroisoquinoline alkaloid exerts anticancer effects at least in part by suppressing NF‑κB‑regulated proteins in A549 human lung cancer cells". Oncology Reports 33, no. 3 (2015): 1141-1146. https://doi.org/10.3892/or.2014.3658
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