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Galanin plays an important role in cancer invasiveness and is associated with poor prognosis in stage II colorectal cancer

  • Authors:
    • Kinuko Nagayoshi
    • Takashi Ueki
    • Kosuke Tashiro
    • Yusuke Mizuuchi
    • Tatsuya Manabe
    • Hiromitsu Araki
    • Yoshinao Oda
    • Satoru Kuhara
    • Masao Tanaka
  • View Affiliations / Copyright

    Affiliations: Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Higashi‑ku, Fukuoka 812-8582, Japan, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Higashi-ku, Fukuoka 812-8581, Japan, Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan
    Copyright: © Nagayoshi et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 539-546
    |
    Published online on: December 9, 2014
       https://doi.org/10.3892/or.2014.3660
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Abstract

Reliable predictors of tumor recurrence for patients with stage II colorectal cancer (CRC) are needed to select patients who should receive adjuvant chemotherapy. Although galanin (GAL) is expressed in several malignant tumors and is associated with cell proliferation and tumor growth, the prognostic value of GAL expression in CRC is poorly understood. We compared GAL expression between 56 patients with stage II and III CRC who developed tumor recurrences and 56 patients who did not. The clinical and prognostic significance of GAL expression was examined using our data and independent public datasets. We also analyzed the influence of GAL expression on the proliferation and invasive activity of CRC cells. Higher expression of GAL was associated with tumor recurrence among the CRC patients (P<0.001). Stage II CRC patients who presented with high expression levels of GAL had significantly poorer prognosis than those with low expression levels of GAL [5-year overall survival: hazard ratio (HR), 7.31; 95% confidence interval (CI), 2.38-24.04; P<0.001; 5-year recurrence-free survival: HR, 3.99; 95% CI, 1.61‑9.44; P=0.004], but there was no association between GAL expression and survival in stage III CRC patients. These findings were supported by analysis of two public datasets. Functionally, siRNA-mediated silencing of GAL resulted in a significant decrease in the proliferative and invasive activities of CRC cells. In conclusion, high expression of GAL is associated with poor prognosis of stage II CRC patients and GAL expression may be related to the aggressive behavior of CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Nagayoshi K, Ueki T, Tashiro K, Mizuuchi Y, Manabe T, Araki H, Oda Y, Kuhara S and Tanaka M: Galanin plays an important role in cancer invasiveness and is associated with poor prognosis in stage II colorectal cancer. Oncol Rep 33: 539-546, 2015.
APA
Nagayoshi, K., Ueki, T., Tashiro, K., Mizuuchi, Y., Manabe, T., Araki, H. ... Tanaka, M. (2015). Galanin plays an important role in cancer invasiveness and is associated with poor prognosis in stage II colorectal cancer. Oncology Reports, 33, 539-546. https://doi.org/10.3892/or.2014.3660
MLA
Nagayoshi, K., Ueki, T., Tashiro, K., Mizuuchi, Y., Manabe, T., Araki, H., Oda, Y., Kuhara, S., Tanaka, M."Galanin plays an important role in cancer invasiveness and is associated with poor prognosis in stage II colorectal cancer". Oncology Reports 33.2 (2015): 539-546.
Chicago
Nagayoshi, K., Ueki, T., Tashiro, K., Mizuuchi, Y., Manabe, T., Araki, H., Oda, Y., Kuhara, S., Tanaka, M."Galanin plays an important role in cancer invasiveness and is associated with poor prognosis in stage II colorectal cancer". Oncology Reports 33, no. 2 (2015): 539-546. https://doi.org/10.3892/or.2014.3660
Copy and paste a formatted citation
x
Spandidos Publications style
Nagayoshi K, Ueki T, Tashiro K, Mizuuchi Y, Manabe T, Araki H, Oda Y, Kuhara S and Tanaka M: Galanin plays an important role in cancer invasiveness and is associated with poor prognosis in stage II colorectal cancer. Oncol Rep 33: 539-546, 2015.
APA
Nagayoshi, K., Ueki, T., Tashiro, K., Mizuuchi, Y., Manabe, T., Araki, H. ... Tanaka, M. (2015). Galanin plays an important role in cancer invasiveness and is associated with poor prognosis in stage II colorectal cancer. Oncology Reports, 33, 539-546. https://doi.org/10.3892/or.2014.3660
MLA
Nagayoshi, K., Ueki, T., Tashiro, K., Mizuuchi, Y., Manabe, T., Araki, H., Oda, Y., Kuhara, S., Tanaka, M."Galanin plays an important role in cancer invasiveness and is associated with poor prognosis in stage II colorectal cancer". Oncology Reports 33.2 (2015): 539-546.
Chicago
Nagayoshi, K., Ueki, T., Tashiro, K., Mizuuchi, Y., Manabe, T., Araki, H., Oda, Y., Kuhara, S., Tanaka, M."Galanin plays an important role in cancer invasiveness and is associated with poor prognosis in stage II colorectal cancer". Oncology Reports 33, no. 2 (2015): 539-546. https://doi.org/10.3892/or.2014.3660
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