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Article

Patrinia scabiosaefolia inhibits the proliferation of colorectal cancer in vitro and in vivo via G1/S cell cycle arrest

  • Authors:
    • Mingyue Zhang
    • Guodong Sun
    • Aling Shen
    • Liya Liu
    • Jingzhen Ding
    • Jun Peng
  • View Affiliations / Copyright

    Affiliations: Hangzhou Naval Sanatorium of Nanjing Military Area Command, Hangzhou, Zhejiang 310002, P.R. China, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Minhou Shangjie, Fuzhou, Fujian 350122, P.R. China, Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093, USA
  • Pages: 856-860
    |
    Published online on: December 10, 2014
       https://doi.org/10.3892/or.2014.3663
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Abstract

Patrinia scabiosaefolia (PS) has long been used as an important component in traditional Chinese medicine formulas to treat gastrointestinal malignancies including colorectal cancer (CRC). We recently reported that PS can inhibit CRC growth through induction of apoptosis and inhibition of tumor angiogenesis. To further elucidate the mode of action of PS, in the present study, we used a CRC mouse xenograft model and a human CRC cell line HT-29 to evaluate the effect of the ethanol extract of PS (EEPS) on cancer cell proliferation and investigated the underlying molecular mechanisms. We found that EEPS inhibited CRC growth both in vivo and in vitro, which was associated with the inhibitory effects of EEPS on cancer cell proliferation. In addition, EEPS treatment significantly blocked G1 to S phase cell cycle progression in HT-29 cells. Moreover, EEPS treatment decreased the expression of pro‑proliferative CyclinD1 and CDK4, at both the mRNA and protein levels. Thus, inhi­bition of cell proliferation via G1/S cell cycle arrest might be a potential mechanism whereby PS effectively treats cancers.
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1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Gustin DM and Brenner DE: Chemoprevention of colon cancer: current status and future prospects. Cancer Metastasis Rev. 21:323–348. 2002. View Article : Google Scholar

3 

Longley DB, Allen WL and Johnston PG: Drug resistance, predictive markers and pharmacogenomics in colorectal cancer. Biochim Biophys Acta. 1766:184–196. 2006.PubMed/NCBI

4 

Sun Y, Zhao H, Guo Y, Lin F, Tang L and Yao Y: Clinical study of combining chemotherapy of oxaliplatin or 5-fluorouracil/leucovorin with hydroxycamptothecine for advanced colorectal cancer. Clin Oncol Cancer Res. 6:117–123. 2009. View Article : Google Scholar

5 

Boose G and Stopper H: Genotoxicity of several clinically used topoisomerase II inhibitors. Toxicol Lett. 116:7–16. 2000. View Article : Google Scholar

6 

Newman DJ, Cragg GM and Snader KM: The influence of natural products upon drug discovery. Nat Prod Rep. 17:215–234. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Gordaliza M: Natural products as leads to anticancer drugs. Clin Transl Oncol. 9:767–776. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Cho EJ, Shin JS, Noh YS, Cho YW, Hong SJ, Park JH, Lee JY, Lee JY and Lee KT: Anti-inflammatory effects of methanol extract of Patrinia scabiosaefolia in mice with ulcerative colitis. J Ethnopharmacol. 136:428–435. 2011. View Article : Google Scholar

9 

Gao L, Zhang L, Li N, Liu JY, Cai PL and Yang SL: New triterpenoid saponins from Patrinia scabiosaefolia. Carbohydr Res. 346:2881–2885. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Ju HK, Baek SH, An RB, Bae K, Son KH, Kim HP, Kang SS, Lee SH, Son JK and Chang HW: Inhibitory effects of nardostachin on nitric oxide, prostaglandin E2, and tumor necrosis factor-alpha production in lipopolysaccharide activated macrophages. Biol Pharm Bull. 26:1375–1378. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Chiu LC, Ho TS, Wong EY and Ooi VE: Ethyl acetate extract of Patrinia scabiosaefolia downregulates anti-apoptotic Bcl-2/Bcl-XL expression, and induces apoptosis in human breast carcinoma MCF-7 cells independent of caspase-9 activation. J Ethnopharmacol. 105:263–268. 2006. View Article : Google Scholar

12 

Peng J, Chen YQ, Lin JM, Zhuang QC, Xu W, Hong ZF and Sferra TJ: Patrinia scabiosaefolia extract suppresses proliferation and promotes apoptosis by inhibiting the STAT3 pathway in human multiple myeloma cells. Mol Med Rep. 4:313–318. 2011.PubMed/NCBI

13 

Liu LY, Shen AL, Chen YQ, Wei LH, Lin JM, Sferra TJ, Hong ZF and Peng J: Patrinia scabiosaefolia induces mitochondrial-dependent apoptosis in a mouse model of colorectal cancer. Oncol Rep. 30:897–903. 2013.PubMed/NCBI

14 

Chen LW, Liu LY, Ye L, Shen AL, Chen YQ, Sferra TJ and Peng J: Patrinia scabiosaefolia inhibits colorectal cancer growth through suppression of tumor angiogenesis. Oncol Rep. 30:1439–1443. 2013.PubMed/NCBI

15 

Evan GI and Vousden KH: Proliferation, cell cycle and apoptosis in cancer. Nature. 411:342–348. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Zhong W, Peng J, He H, Wu D, Han Z, Bi X and Dai Q: Ki-67 and PCNA expression in prostate cancer and benign prostatic hyperplasia. Clin Invest Med. 31:E8–E15. 2008.PubMed/NCBI

17 

Nurse P: Ordering S phase and M phase in the cell cycle. Cell. 79:547–550. 1994. View Article : Google Scholar : PubMed/NCBI

18 

Chen Y, Robles AI, Martinez LA, Liu F, Gimenez-Conti IB and Conti CJ: Expression of G1 cyclins, cyclin-dependent kinases, and cyclin-dependent kinase inhibitors in androgen-induced prostate proliferation in castrated rats. Cell Growth Differ. 7:1571–1578. 1996.PubMed/NCBI

19 

Grana X and Redy EP: Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene. 11:211–219. 1995.PubMed/NCBI

20 

Morgan DO: Principles of CDK regulation. Nature. 374:131–134. 1995. View Article : Google Scholar : PubMed/NCBI

21 

Harakeh S, Abu-El-Ardat K, Diab-Assaf M, Niedzwiecki A, El-Sabban M and Rath M: Epigallocatechin-3-gallate induces apoptosis and cell cycle arrest in HTLV-1-positive and -negative leukemia cells. Med Oncol. 25:30–39. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Kessel D and Luo Y: Cells in cryptophycin-induced cell-cycle arrest are susceptible to apoptosis. Cancer Lett. 151:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Purohit A, Hejaz HAM, Walden L, MacCarthy-Morrogh L, Packham G, Potter BVL and Reed MJ: The effect of 2-methoxyoestrone-3-O-sulphamate on the growth of breast cancer cells and induced mammary tumours. Int J Cancer. 85:584–589. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Zafonte BT, Hulit J, Amanatullah DF, Albanese C, Wang C, Rosen E, Reutens A, Sparano JA, Lisanti MP and Pestell RG: Cell-cycle dysregulation in breast cancer: breast cancer therapies targeting the cell cycle. Front Biosci. 5:D938–D961. 2000. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang M, Sun G, Shen A, Liu L, Ding J and Peng J: Patrinia scabiosaefolia inhibits the proliferation of colorectal cancer in vitro and in vivo via G1/S cell cycle arrest. Oncol Rep 33: 856-860, 2015.
APA
Zhang, M., Sun, G., Shen, A., Liu, L., Ding, J., & Peng, J. (2015). Patrinia scabiosaefolia inhibits the proliferation of colorectal cancer in vitro and in vivo via G1/S cell cycle arrest. Oncology Reports, 33, 856-860. https://doi.org/10.3892/or.2014.3663
MLA
Zhang, M., Sun, G., Shen, A., Liu, L., Ding, J., Peng, J."Patrinia scabiosaefolia inhibits the proliferation of colorectal cancer in vitro and in vivo via G1/S cell cycle arrest". Oncology Reports 33.2 (2015): 856-860.
Chicago
Zhang, M., Sun, G., Shen, A., Liu, L., Ding, J., Peng, J."Patrinia scabiosaefolia inhibits the proliferation of colorectal cancer in vitro and in vivo via G1/S cell cycle arrest". Oncology Reports 33, no. 2 (2015): 856-860. https://doi.org/10.3892/or.2014.3663
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang M, Sun G, Shen A, Liu L, Ding J and Peng J: Patrinia scabiosaefolia inhibits the proliferation of colorectal cancer in vitro and in vivo via G1/S cell cycle arrest. Oncol Rep 33: 856-860, 2015.
APA
Zhang, M., Sun, G., Shen, A., Liu, L., Ding, J., & Peng, J. (2015). Patrinia scabiosaefolia inhibits the proliferation of colorectal cancer in vitro and in vivo via G1/S cell cycle arrest. Oncology Reports, 33, 856-860. https://doi.org/10.3892/or.2014.3663
MLA
Zhang, M., Sun, G., Shen, A., Liu, L., Ding, J., Peng, J."Patrinia scabiosaefolia inhibits the proliferation of colorectal cancer in vitro and in vivo via G1/S cell cycle arrest". Oncology Reports 33.2 (2015): 856-860.
Chicago
Zhang, M., Sun, G., Shen, A., Liu, L., Ding, J., Peng, J."Patrinia scabiosaefolia inhibits the proliferation of colorectal cancer in vitro and in vivo via G1/S cell cycle arrest". Oncology Reports 33, no. 2 (2015): 856-860. https://doi.org/10.3892/or.2014.3663
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