Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
February-2015 Volume 33 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2015 Volume 33 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Case-control study of the PERIOD3 clock gene length polymorphism and colorectal adenoma formation

  • Authors:
    • Melannie Alexander
    • James B. Burch
    • Susan E. Steck
    • Chin‑Fu Chen
    • Thomas G. Hurley
    • Philip Cavicchia
    • Meredith Ray
    • Nitin Shivappa
    • Jaclyn Guess
    • Hongmei Zhang
    • Shawn D. Youngstedt
    • Kim E. Creek
    • Stephen Lloyd
    • Xiaoming Yang
    • James R. Hébert
  • View Affiliations / Copyright

    Affiliations: South Carolina Statewide Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, USA, Center for Molecular Studies, Greenwood Genetic Center, Greenwood, SC, USA, Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA, Division of Epidemiology, Biostatistics and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA, College of Nursing and Health Innovation, and College of Health Solutions, Arizona State University, Phoenix, AZ, USA, Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC, USA, South Carolina Medical Endoscopy Center, and Department of Family Medicine, University of South Carolina School of Medicine, Columbia, SC, USA, Medical Chronobiology Laboratory, Dorn Department of Veterans Affairs Medical Center, Columbia, SC, USA
  • Pages: 935-941
    |
    Published online on: December 11, 2014
       https://doi.org/10.3892/or.2014.3667
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Clock genes are expressed in a self-perpetuating, circadian pattern in virtually every tissue including the human gastrointestinal tract. They coordinate cellular processes critical for tumor development, including cell proliferation, DNA damage response and apoptosis. Circadian rhythm disturbances have been associated with an increased risk for colon cancer and other cancers. This mechanism has not been elucidated, yet may involve dysregulation of the ‘period’ (PER) clock genes, which have tumor suppressor properties. A variable number tandem repeat (VNTR) in the PERIOD3 (PER3) gene has been associated with sleep disorders, differences in diurnal hormone secretion, and increased premenopausal breast cancer risk. Susceptibility related to PER3 has not been examined in conjunction with adenomatous polyps. This exploratory case-control study was the first to test the hypothesis that the 5-repeat PER3 VNTR sequence is associated with increased odds of adenoma formation. Information on demographics, medical history, occupation and lifestyle was collected prior to colonoscopy. Cases (n=49) were individuals with at least one histopathologically confirmed adenoma. Controls (n=97) included patients with normal findings or hyperplastic polyps not requiring enhanced surveillance. Unconditional multiple logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs), after adjusting for potential confounding. Adenomas were detected in 34% of participants. Cases were more likely to possess the 5-repeat PER3 genotype relative to controls (4/5 OR, 2.1; 95% CI, 0.9-4.8; 5/5 OR, 5.1; 95% CI, 1.4-18.1; 4/5+5/5 OR, 2.5; 95% CI, 1.7-5.4). Examination of the Oncomine microarray database indicated lower PERIOD gene expression in adenomas relative to adjacent normal tissue. Results suggest a need for follow-up in a larger sample.
View Figures
View References

1 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Conteduca V, Sansonno D, Russi S and Dammacco F: Precancerous colorectal lesions (Review). Int J Oncol. 43:973–984. 2013.PubMed/NCBI

3 

Haus EL and Smolensky MH: Shift work and cancer risk: potential mechanistic roles of circadian disruption, light at night, and sleep deprivation. Sleep Med Rev. 17:273–284. 2013. View Article : Google Scholar

4 

Lahti T, Merikanto I and Partonen T: Circadian clock disruptions and the risk of cancer. Ann Med. 44:847–853. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Landgraf D, Shostak A and Oster H: Clock genes and sleep. Pflugers Archiv. 463:3–14. 2012. View Article : Google Scholar

6 

Masri S, Zocchi L, Katada S, Mora E and Sassone-Corsi P: The circadian clock transcriptional complex: metabolic feedback intersects with epigenetic control. Ann NY Acad Sci. 1264:103–109. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Panda S, Antoch MP, Miller BH, et al: Coordinated transcription of key pathways in the mouse by the circadian clock. Cell. 109:307–320. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Schibler U: The daily timing of gene expression and physiology in mammals. Dialogues Clin Neurosci. 9:257–272. 2007.PubMed/NCBI

9 

Ripperger JA and Merrow M: Perfect timing: epigenetic regulation of the circadian clock. FEBS Lett. 585:1406–1411. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Storch KF, Lipan O, Leykin I, et al: Extensive and divergent circadian gene expression in liver and heart. Nature. 417:78–83. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Wood P, Yang X and Hrushesky W: The role of circadian rhythm in pathogenesis of colorectal cancer. Curr Colorectal Cancer Rep. 6:74–81. 2010. View Article : Google Scholar

12 

Kang TH and Sancar A: Circadian regulation of DNA excision repair: implications for chrono-chemotherapy. Cell Cycle. 8:1665–1667. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Yu EA and Weaver DR: Disrupting the circadian clock: gene-specific effects on aging, cancer, and other phenotypes. Aging. 3:479–493. 2011.PubMed/NCBI

14 

Yang MY, Yang WC, Lin PM, et al: Altered expression of circadian clock genes in human chronic myeloid leukemia. J Biol Rhythms. 26:136–148. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Chen-Goodspeed M and Lee CC: Tumor suppression and circadian function. J Biol Rhythms. 22:291–298. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Dijk DJ and Archer SN: PERIOD3, circadian phenotypes, and sleep homeostasis. Sleep Med Rev. 14:151–160. 2010. View Article : Google Scholar

17 

Ebisawa T: Analysis of the molecular pathophysiology of sleep disorders relevant to a disturbed biological clock. Mol Genet Genomics. 288:185–193. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Thompson CL, Larkin EK, Patel S, Berger NA, Redline S and Li L: Short duration of sleep increases risk of colorectal adenoma. Cancer. 117:841–847. 2011. View Article : Google Scholar :

19 

Burch JB, Wirth M and Yang X: Disruption of circadian rhythms and sleep: role in carcinogenesis. The Encyclopedia of Sleep. Kushida CA: 3. Academic Press; Waltham, MA: pp. 150–155. 2013, View Article : Google Scholar

20 

Jiao L, Duan Z, Sangi-Haghpeykar H, Hale L, White DL and El-Serag HB: Sleep duration and incidence of colorectal cancer in postmenopausal women. Br J Cancer. 108:213–221. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Wirth MD, Burch JB, Hébert JR, et al: Case-control study of breast cancer in India: Role of PERIOD3 clock gene length polymorphism and chronotype. Cancer Invest. 32:321–329. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Schernhammer ES, Laden F, Speizer FE, et al: Night-shift work and risk of colorectal cancer in the nurses’ health study. J Natl Cancer Inst. 95:825–828. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Parent MÉ, El-Zein M, Rousseau MC, Pintos J and Siemiatycki J: Night work and the risk of cancer among men. Am J Epidemiol. 176:751–759. 2012. View Article : Google Scholar : PubMed/NCBI

24 

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Painting, Firefighting and Shiftwork. International Agency for Research on Cancer. World Health Organization; 98. Lyon, France: 2010

25 

Scheiermann C, Kunisaki Y and Frenette PS: Circadian control of the immune system. Nat Rev Immunol. 13:190–198. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Arjona A, Silver AC, Walker WE and Fikrig E: Immunity’s fourth dimension: approaching the circadian-immune connection. Trends Immunol. 33:607–612. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Climent J, Perez-Losada J, Quigley DA, et al: Deletion of the PER3 gene on chromosome 1p36 in recurrent ER-positive breast cancer. J Clin Oncol. 28:3770–3778. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Neumann O, Kesselmeier M, Geffers R, et al: Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors. Hepatology. 56:1817–1827. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Cao Q, Gery S, Dashti A, et al: A role for the clock gene Per1 in prostate cancer. Cancer Res. 69:7619–7625. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Gery S, Komatsu N, Baldjyan L, Yu A, Koo D and Koeffler HP: The circadian gene Per1 plays an important role in cell growth and DNA damage control in human cancer cells. Mol Cell. 22:375–382. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Hua H, Wang Y, Wan C, et al: Circadian gene mPer2 overexpression induces cancer cell apoptosis. Cancer Sci. 97:589–596. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Wang X, Yan D, Teng M, et al: Reduced expression of PER3 is associated with incidence and development of colon cancer. Ann Surg Oncol. 19:3081–3088. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Zhu Y, Brown HN, Zhang Y, Stevens RG and Zheng T: Period3 structural variation: a circadian biomarker associated with breast cancer in young women. Cancer Epidemiol Biomarkers Prev. 14:268–270. 2005.PubMed/NCBI

34 

Mazzoccoli G, Panza A, Valvano MR, et al: Clock gene expression levels and relationship with clinical and pathological features in colorectal cancer patients. Chronobiol Int. 28:841–851. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Oshima T, Takenoshita S, Akaike M, et al: Expression of circadian genes correlates with liver metastasis and outcomes in colorectal cancer. Oncol Rep. 25:1439–1446. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Mostafaie N, Kállay E, Sauerzapf E, et al: Correlated downregulation of estrogen receptor beta and the circadian clock gene Per1 in human colorectal cancer. Mol Carcinog. 48:642–647. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Wirth M, Burch J, Violanti J, et al: Association of the Period3 clock gene length polymorphism with salivary cortisol secretion among police officers. Neuro Endocrinol Lett. 34:27–37. 2013.PubMed/NCBI

38 

Lázár AS, Slak A, Lo JC, et al: Sleep, diurnal preference, health, and psychological well-being: a prospective single-allelic-variation study. Chronobiol Int. 29:131–146. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Pereira DS, Tufik S, Louzada FM, et al: Association of the length polymorphism in the human Per3 gene with the delayed sleep-phase syndrome: does latitude have an influence upon it? Sleep. 28:29–32. 2005.PubMed/NCBI

40 

Viola AU, Chellappa SL, Archer SN, et al: Interindividual differences in circadian rhythmicity and sleep homeostasis in older people: effect of a PER3 polymorphism. Neurobiol Aging. 33:1010.e17–1010.e27. 2012. View Article : Google Scholar

41 

Chellappa SL, Viola AU, Schmidt C, et al: Human melatonin and alerting response to blue-enriched light depend on a polymorphism in the clock gene PER3. J Clin Endocrinol Metab. 97:E433–E437. 2012. View Article : Google Scholar

42 

Guess J, Burch JB, Ogoussan K, et al: Circadian disruption, Per3, and human cytokine secretion. Integr Cancer Ther. 8:329–336. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Benedetti F, Dallaspezia S, Colombo C, Pirovano A, Marino E and Smeraldi E: A length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder. Neurosci Lett. 445:184–187. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Dai H, Zhang L, Cao M, et al: The role of polymorphisms in circadian pathway genes in breast tumorigenesis. Breast Cancer Res Treat. 127:531–540. 2011. View Article : Google Scholar

45 

Karantanos T, Theodoropoulos G, Gazouli M, et al: Association of the clock genes polymorphisms with colorectal cancer susceptibility. J Surg Oncol. 108:563–567. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Ebisawa T, Uchiyama M, Kajimura N, et al: Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome. EMBO Rep. 2:342–346. 2001. View Article : Google Scholar : PubMed/NCBI

47 

Nievergelt CM, Kripke DF, Barrett TB, et al: Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 141B:234–241. 2006. View Article : Google Scholar : PubMed/NCBI

48 

Archer SN, Robilliard DL, Skene DJ, et al: A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference. Sleep. 26:413–415. 2003.PubMed/NCBI

49 

Rhodes DR, Kalyana-Sundaram S, Mahavisno V, et al: Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. Neoplasia. 9:166–180. 2007. View Article : Google Scholar : PubMed/NCBI

50 

Barbosa AA, Pedrazzolli M, Koike BD and Tufik S: Do Caucasian and Asian Clocks Tick Differently? Braz J Med Biol Res. 43:96–99. 2010. View Article : Google Scholar

51 

Gaspar C, Cardoso J, Franken P, et al: Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis. Am J Pathol. 172:1363–1380. 2008. View Article : Google Scholar : PubMed/NCBI

52 

Sabates-Bellver J, Van der Flier LG, de Palo M, et al: Transcriptome profile of human colorectal adenomas. Mol Cancer Res. 5:1263–1275. 2007. View Article : Google Scholar

53 

Skrzypczak M, Goryca K, Rubel T, et al: Modeling oncogenic signaling in colon tumors by multidirectional analyses of microarray data directed for maximization of analytical reliability. PLoS One. 5:pii: e13091. 2010. View Article : Google Scholar : PubMed/NCBI

54 

Xirasagar S, Hurley TG, Sros L and Hebert JR: Quality and safety of screening colonoscopies performed by primary care physicians with standby specialist support. Med Care. 48:703–709. 2010. View Article : Google Scholar : PubMed/NCBI

55 

Rex DK, Kahi CJ, Levin B, et al: Guidelines for colonoscopy surveillance after cancer resection: a consensus update by the American Cancer Society and US Multi-Society Task Force on Colorectal Cancer. CA Cancer J Clin. 56:160–167; quiz 185-166. 2006. View Article : Google Scholar : PubMed/NCBI

56 

Krugluger W, Brandstaetter A, Kállay E, et al: Regulation of genes of the circadian clock in human colon cancer: reduced period-1 and dihydropyrimidine dehydrogenase transcription correlates in high-grade tumors. Cancer Res. 67:7917–7922. 2007. View Article : Google Scholar : PubMed/NCBI

57 

Karantanos T, Theodoropoulos G, Gazouli M, Vaiopoulou A, Karantanou C, Lymberi M and Pektasides D: Expression of clock genes in patients with colorectal cancer. Int J Biol Markers. 28:280–285. 2013. View Article : Google Scholar : PubMed/NCBI

58 

Tenesa A and Dunlop MG: New insights into the aetiology of colorectal cancer from genome-wide association studies. Nat Rev Genet. 10:353–358. 2009. View Article : Google Scholar : PubMed/NCBI

59 

Tomlinson IP, Dunlop M, Campbell H, et al: COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer. Br J Cancer. 102:447–454. 2010. View Article : Google Scholar :

60 

Mazzoccoli G, Palmieri O, Corritore G, et al: Association study of a polymorphism in clock gene PERIOD3 and risk of inflammatory bowel disease. Chronobiol Int. 29:994–1003. 2012. View Article : Google Scholar : PubMed/NCBI

61 

Lee CC: The circadian clock and tumor suppression by mammalian period genes. Methods Enzymol. 393:852–861. 2005. View Article : Google Scholar : PubMed/NCBI

62 

Gery S and Koeffler HP: Circadian rhythms and cancer. Cell Cycle. 9:1097–1103. 2010. View Article : Google Scholar : PubMed/NCBI

63 

Voinescu BI and Coogan AN: A variable-number tandem repeat polymorphism in PER3 is not associated with chronotype in a population with self-reported sleep problems. Sleep and Biological Rhythms. 10:23–26. 2012. View Article : Google Scholar

64 

Osland TM, Bjorvatn BR, Steen VM and Pallesen S: Association study of a variable-number tandem repeat polymorphism in the clock gene PERIOD3 and chronotype in Norwegian university students. Chronobiol Int. 28:764–770. 2011. View Article : Google Scholar : PubMed/NCBI

65 

Barclay NL, Eley TC, Mill J, et al: Sleep quality and diurnal preference in a sample of young adults: associations with 5HTTLPR, PER3, and CLOCK 3111. Am J Med Genet B Neuropsychiatr Genet. 156B:681–690. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Alexander M, Burch JB, Steck SE, Chen CF, Hurley TG, Cavicchia P, Ray M, Shivappa N, Guess J, Zhang H, Zhang H, et al: Case-control study of the PERIOD3 clock gene length polymorphism and colorectal adenoma formation. Oncol Rep 33: 935-941, 2015.
APA
Alexander, M., Burch, J.B., Steck, S.E., Chen, C., Hurley, T.G., Cavicchia, P. ... Hébert, J.R. (2015). Case-control study of the PERIOD3 clock gene length polymorphism and colorectal adenoma formation. Oncology Reports, 33, 935-941. https://doi.org/10.3892/or.2014.3667
MLA
Alexander, M., Burch, J. B., Steck, S. E., Chen, C., Hurley, T. G., Cavicchia, P., Ray, M., Shivappa, N., Guess, J., Zhang, H., Youngstedt, S. D., Creek, K. E., Lloyd, S., Yang, X., Hébert, J. R."Case-control study of the PERIOD3 clock gene length polymorphism and colorectal adenoma formation". Oncology Reports 33.2 (2015): 935-941.
Chicago
Alexander, M., Burch, J. B., Steck, S. E., Chen, C., Hurley, T. G., Cavicchia, P., Ray, M., Shivappa, N., Guess, J., Zhang, H., Youngstedt, S. D., Creek, K. E., Lloyd, S., Yang, X., Hébert, J. R."Case-control study of the PERIOD3 clock gene length polymorphism and colorectal adenoma formation". Oncology Reports 33, no. 2 (2015): 935-941. https://doi.org/10.3892/or.2014.3667
Copy and paste a formatted citation
x
Spandidos Publications style
Alexander M, Burch JB, Steck SE, Chen CF, Hurley TG, Cavicchia P, Ray M, Shivappa N, Guess J, Zhang H, Zhang H, et al: Case-control study of the PERIOD3 clock gene length polymorphism and colorectal adenoma formation. Oncol Rep 33: 935-941, 2015.
APA
Alexander, M., Burch, J.B., Steck, S.E., Chen, C., Hurley, T.G., Cavicchia, P. ... Hébert, J.R. (2015). Case-control study of the PERIOD3 clock gene length polymorphism and colorectal adenoma formation. Oncology Reports, 33, 935-941. https://doi.org/10.3892/or.2014.3667
MLA
Alexander, M., Burch, J. B., Steck, S. E., Chen, C., Hurley, T. G., Cavicchia, P., Ray, M., Shivappa, N., Guess, J., Zhang, H., Youngstedt, S. D., Creek, K. E., Lloyd, S., Yang, X., Hébert, J. R."Case-control study of the PERIOD3 clock gene length polymorphism and colorectal adenoma formation". Oncology Reports 33.2 (2015): 935-941.
Chicago
Alexander, M., Burch, J. B., Steck, S. E., Chen, C., Hurley, T. G., Cavicchia, P., Ray, M., Shivappa, N., Guess, J., Zhang, H., Youngstedt, S. D., Creek, K. E., Lloyd, S., Yang, X., Hébert, J. R."Case-control study of the PERIOD3 clock gene length polymorphism and colorectal adenoma formation". Oncology Reports 33, no. 2 (2015): 935-941. https://doi.org/10.3892/or.2014.3667
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team