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Article

Baicalein inhibits the invasion of gastric cancer cells by suppressing the activity of the p38 signaling pathway

  • Authors:
    • Xi Yan
    • Xiaojiang Rui
    • Kai Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, 323 Hospital of People's Liberation Army, Xi'an, Shaanxi 710054, P.R. China
  • Pages: 737-743
    |
    Published online on: December 11, 2014
       https://doi.org/10.3892/or.2014.3669
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Abstract

Baicalein, one of the major flavonoids in Scutellaria baicalensis, has been used in anti-inflammatory and anticancer therapies for a long time. However, the antimetastatic effects and related mechanism(s) in gastric cancer remain unclear. In the present study, we tested the hypothesis that administration of baicalein may inhibit the proliferation, motility and invasion of human gastric cancer cell lines by regulating the p38 signaling pathway. In the present study, we found that baicalein could inhibit migration and invasion of gastric cancer cells. Additionally, after treating with baicalein for 24 h, the expression levels of matrix metalloproteinase (MMP)-2 and -9 as well as proteinase activity in gastric cancer cells were reduced in a dose-dependent manner. Moreover, baicalein clearly reduced the phosphorylated levels of p38. Combined treatment with p38 activator partially blocked the antimetastatic effects of baicalein, while p38 inhibitor (SB203580) and baicalein resulted in a synergistic reduction in MMP-2 and -9 expression; the invasive ability of gastric cancer cells was also inhibited. In conclusion, baicalein inhibits gastric cancer cell invasion and metastasis by reducing cell motility and migration via suppression of the p38 signaling pathway, suggesting that baicalein is a potential therapeutic agent for gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Yan X, Rui X and Zhang K: Baicalein inhibits the invasion of gastric cancer cells by suppressing the activity of the p38 signaling pathway. Oncol Rep 33: 737-743, 2015.
APA
Yan, X., Rui, X., & Zhang, K. (2015). Baicalein inhibits the invasion of gastric cancer cells by suppressing the activity of the p38 signaling pathway. Oncology Reports, 33, 737-743. https://doi.org/10.3892/or.2014.3669
MLA
Yan, X., Rui, X., Zhang, K."Baicalein inhibits the invasion of gastric cancer cells by suppressing the activity of the p38 signaling pathway". Oncology Reports 33.2 (2015): 737-743.
Chicago
Yan, X., Rui, X., Zhang, K."Baicalein inhibits the invasion of gastric cancer cells by suppressing the activity of the p38 signaling pathway". Oncology Reports 33, no. 2 (2015): 737-743. https://doi.org/10.3892/or.2014.3669
Copy and paste a formatted citation
x
Spandidos Publications style
Yan X, Rui X and Zhang K: Baicalein inhibits the invasion of gastric cancer cells by suppressing the activity of the p38 signaling pathway. Oncol Rep 33: 737-743, 2015.
APA
Yan, X., Rui, X., & Zhang, K. (2015). Baicalein inhibits the invasion of gastric cancer cells by suppressing the activity of the p38 signaling pathway. Oncology Reports, 33, 737-743. https://doi.org/10.3892/or.2014.3669
MLA
Yan, X., Rui, X., Zhang, K."Baicalein inhibits the invasion of gastric cancer cells by suppressing the activity of the p38 signaling pathway". Oncology Reports 33.2 (2015): 737-743.
Chicago
Yan, X., Rui, X., Zhang, K."Baicalein inhibits the invasion of gastric cancer cells by suppressing the activity of the p38 signaling pathway". Oncology Reports 33, no. 2 (2015): 737-743. https://doi.org/10.3892/or.2014.3669
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