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Article

Deferoxamine inhibits TRAIL-mediated apoptosis via regulation of autophagy in human colon cancer cells

  • Authors:
    • Ji-Hong Moon
    • Jae-Kyo Jeong
    • Sang-Youel Park
  • View Affiliations / Copyright

    Affiliations: Biosafety Research Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea
  • Pages: 1171-1176
    |
    Published online on: December 18, 2014
       https://doi.org/10.3892/or.2014.3676
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Abstract

Deferoxamine (DFO), an iron chelator, has numerous clinical applications for patients presenting with iron overload in regards to the improvement in the quality of life and overall survival. In addition, experimental iron chelators have demonstrated potent anticancer properties. The present study investigated the effects of DFO on TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in colon cancer cells and and the mechanism involved. The experimental results showed that DFO treatment inhibited TRAIL-mediated cancer cell apoptosis by increasing Akt activation and decreasing caspase activation in human colon cancer cells. Furthermore, DFO treatment induced autophagy flux, and chloroquine, an autophagy inhibitor, blocked DFO-mediated inhibition of TRAIL-induced apoptosis. The present study demonstrated that DFO inhibited TRAIL-mediated tumor cell death via the autophagy pathway, and the results suggest that potent anticancer agent, DFO, can be an inhibitor against antitumor therapy including TRAIL protein.
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1 

Steller H: Mechanisms and genes of cellular suicide. Science. 267:1445–1449. 1995. View Article : Google Scholar : PubMed/NCBI

2 

Hickman JA: Apoptosis induced by anticancer drugs. Cancer Metastasis Rev. 11:121–139. 1992. View Article : Google Scholar : PubMed/NCBI

3 

Zhang JY: Apoptosis-based anticancer drugs. Nat Rev Drug Discov. 1:101–102. 2002. View Article : Google Scholar : PubMed/NCBI

4 

MacFarlane M: TRAIL-induced signalling and apoptosis. Toxicol Lett. 139:89–97. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Lieu PT, Heiskala M, Peterson PA and Yang Y: The roles of iron in health and disease. Mol Aspects Med. 22:1–87. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Toyokuni S: Iron-induced carcinogenesis: the role of redox regulation. Free Radic Biol Med. 20:553–566. 1996. View Article : Google Scholar : PubMed/NCBI

7 

Nelson RL: Dietary iron and colorectal cancer risk. Free Radic Biol Med. 12:161–168. 1992. View Article : Google Scholar : PubMed/NCBI

8 

Bedford MR, Ford SJ, Horniblow RD, Iqbal TH and Tselepis C: Iron chelation in the treatment of cancer: a new role for deferasirox? J Clin Pharmacol. 53:885–891. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Nurtjahja-Tjendraputra E, Fu D, Phang JM and Richardson DR: Iron chelation regulates cyclin D1 expression via the proteasome: a link to iron deficiency-mediated growth suppression. Blood. 109:4045–4054. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Fu D and Richardson DR: Iron chelation and regulation of the cell cycle: 2 mechanisms of posttranscriptional regulation of the universal cyclin-dependent kinase inhibitor p21CIP1/WAF1 by iron depletion. Blood. 110:752–761. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Hershko C: Control of disease by selective iron depletion: a novel therapeutic strategy utilizing iron chelators. Baillieres Clin Haematol. 7:965–1000. 1994. View Article : Google Scholar : PubMed/NCBI

12 

Olivieri NF and Brittenham GM: Iron-chelating therapy and the treatment of thalassemia. Blood. 89:739–761. 1997.PubMed/NCBI

13 

Yun Z, Maecker HL, Johnson RS and Giaccia AJ: Inhibition of PPARγ2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Dev Cell. 2:331–341. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Nakayama K: Cellular signal transduction of the hypoxia response. J Biochem. 146:757–765. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Semenza GL: Targeting HIF-1 for cancer therapy. Nat Rev Cancer. 3:721–732. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Deter RL and De Duve C: Influence of glucagon, an inducer of cellular autophagy, on some physical properties of rat liver lysosomes. J Cell Biol. 33:437–449. 1967. View Article : Google Scholar : PubMed/NCBI

17 

Levine B and Kroemer G: Autophagy in the pathogenesis of disease. Cell. 132:27–42. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Boya P, González-Polo RA, Casares N, et al: Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol. 25:1025–1040. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Karantza-Wadsworth V, Patel S, Kravchuk O, et al: Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev. 21:1621–1635. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Degenhardt K, Mathew R, Beaudoin B, et al: Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell. 10:51–64. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Lum JJ, Bauer DE, Kong M, et al: Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell. 120:237–248. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Hu YL, DeLay M, Jahangiri A, et al: Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma. Cancer Res. 72:1773–1783. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Chaudhari AA, Seol JW, Lee YJ, Seol DW and Park SY: Hypoxia protects articular chondrocytes from thapsigargin-induced apoptosis. Biochem Biophys Res Commun. 381:513–517. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Agarwal E, Brattain MG and Chowdhury S: Cell survival and metastasis regulation by Akt signaling in colorectal cancer. Cell Signal. 25:1711–1719. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Degterev A, Boyce M and Yuan J: A decade of caspases. Oncogene. 22:8543–8567. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Rubinsztein DC, Cuervo AM, Ravikumar B, et al: In search of an ‘autophagomometer’. Autophagy. 5:585–589. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Matsumoto G, Wada K, Okuno M, Kurosawa M and Nukina N: Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins. Mol Cell. 44:279–289. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Kroemer G and Jäättelä M: Lysosomes and autophagy in cell death control. Nat Rev Cancer. 5:886–897. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Liu Y, Cui Y, Shi M, Zhang Q, Wang Q and Chen X: Deferoxamine promotes MDA-MB-231 cell migration and invasion through increased ROS-dependent HIF-1α accumulation. Cell Physiol Biochem. 33:1036–1046. 2014. View Article : Google Scholar

30 

Bertout JA, Patel SA and Simon MC: The impact of O2 availability on human cancer. Nat Rev Cancer. 8:967–975. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Mazure NM and Pouysségur J: Atypical BH3-domains of BNIP3 and BNIP3L lead to autophagy in hypoxia. Autophagy. 5:868–869. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Gustafsson AB and Gottlieb RA: Autophagy in ischemic heart disease. Circ Res. 104:150–158. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Wang K, Liu R, Li J, et al: Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling. Autophagy. 7:966–978. 2011. View Article : Google Scholar : PubMed/NCBI

34 

White E and DiPaola RS: The double-edged sword of autophagy modulation in cancer. Clin Cancer Res. 15:5308–5316. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Glick D, Barth S and Macleod KF: Autophagy: cellular and molecular mechanisms. J Pathol. 221:3–12. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Mizushima N: Autophagy: process and function. Genes Dev. 21:2861–2873. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Mizushima N, Yoshimori T and Levine B: Methods in mammalian autophagy research. Cell. 140:313–326. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Singh K, Sharma A, Mir MC, et al: Autophagic flux determines cell death and survival in response to Apo2L/TRAIL (dulanermin). Mol Cancer. 13:702014. View Article : Google Scholar : PubMed/NCBI

39 

Park KJ, Lee SH, Kim TI, et al: A human scFv antibody against TRAIL receptor 2 induces autophagic cell death in both TRAIL-sensitive and TRAIL-resistant cancer cells. Cancer Res. 67:7327–7334. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Ikeda Y, Tajima S, Yoshida S, et al: Deferoxamine promotes angiogenesis via the activation of vascular endothelial cell function. Atherosclerosis. 215:339–347. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Moon J, Jeong J and Park S: Deferoxamine inhibits TRAIL-mediated apoptosis via regulation of autophagy in human colon cancer cells. Oncol Rep 33: 1171-1176, 2015.
APA
Moon, J., Jeong, J., & Park, S. (2015). Deferoxamine inhibits TRAIL-mediated apoptosis via regulation of autophagy in human colon cancer cells. Oncology Reports, 33, 1171-1176. https://doi.org/10.3892/or.2014.3676
MLA
Moon, J., Jeong, J., Park, S."Deferoxamine inhibits TRAIL-mediated apoptosis via regulation of autophagy in human colon cancer cells". Oncology Reports 33.3 (2015): 1171-1176.
Chicago
Moon, J., Jeong, J., Park, S."Deferoxamine inhibits TRAIL-mediated apoptosis via regulation of autophagy in human colon cancer cells". Oncology Reports 33, no. 3 (2015): 1171-1176. https://doi.org/10.3892/or.2014.3676
Copy and paste a formatted citation
x
Spandidos Publications style
Moon J, Jeong J and Park S: Deferoxamine inhibits TRAIL-mediated apoptosis via regulation of autophagy in human colon cancer cells. Oncol Rep 33: 1171-1176, 2015.
APA
Moon, J., Jeong, J., & Park, S. (2015). Deferoxamine inhibits TRAIL-mediated apoptosis via regulation of autophagy in human colon cancer cells. Oncology Reports, 33, 1171-1176. https://doi.org/10.3892/or.2014.3676
MLA
Moon, J., Jeong, J., Park, S."Deferoxamine inhibits TRAIL-mediated apoptosis via regulation of autophagy in human colon cancer cells". Oncology Reports 33.3 (2015): 1171-1176.
Chicago
Moon, J., Jeong, J., Park, S."Deferoxamine inhibits TRAIL-mediated apoptosis via regulation of autophagy in human colon cancer cells". Oncology Reports 33, no. 3 (2015): 1171-1176. https://doi.org/10.3892/or.2014.3676
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