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Article

Paired related homeobox 1 is associated with the invasive properties of glioblastoma cells

  • Authors:
    • Mai Sugiyama
    • Hitoki Hasegawa
    • Satoko Ito
    • Kazuya Sugiyama
    • Masao Maeda
    • Kosuke Aoki
    • Toshihiko Wakabayashi
    • Michinari Hamaguchi
    • Atsushi Natsume
    • Takeshi Senga
  • View Affiliations / Copyright

    Affiliations: Division of Cancer Biology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya 466-8550, Japan, Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya 466-8550, Japan, Department of Neurosurgery, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya 466-8550, Japan
  • Pages: 1123-1130
    |
    Published online on: December 18, 2014
       https://doi.org/10.3892/or.2014.3681
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Abstract

Glioblastoma is a highly proliferative and invasive tumor. Despite extensive efforts to develop treatments for glioblastoma, the currently available therapies have only limited effects. To develop novel strategies for glioblastoma treatment, it is crucial to elucidate the molecular mechanisms that promote the invasive properties of glioblastoma. In the present study, we showed that the paired related homeobox 1 (PRRX1) is associated with glioblastoma cell invasion. The depletion of PRRX1 suppressed the invasion and neurosphere formation of glioblastoma cells. Conversely, the exogenous expression of PRRX1 promoted invasion. The Notch signaling pathway, which is an evolutionarily conserved pathway that is essential for developmental processes, plays an important role in the tumorigenesis of glioblastoma. The expression of PRRX1 induced the activation of Notch signaling, and the inhibition of Notch signaling suppressed PRRX1-mediated cell invasion. Our results indicate that activation of Notch signaling by PRRX1 is associated with the promotion of glioblastoma cell invasion.
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Copy and paste a formatted citation
Spandidos Publications style
Sugiyama M, Hasegawa H, Ito S, Sugiyama K, Maeda M, Aoki K, Wakabayashi T, Hamaguchi M, Natsume A, Senga T, Senga T, et al: Paired related homeobox 1 is associated with the invasive properties of glioblastoma cells. Oncol Rep 33: 1123-1130, 2015.
APA
Sugiyama, M., Hasegawa, H., Ito, S., Sugiyama, K., Maeda, M., Aoki, K. ... Senga, T. (2015). Paired related homeobox 1 is associated with the invasive properties of glioblastoma cells. Oncology Reports, 33, 1123-1130. https://doi.org/10.3892/or.2014.3681
MLA
Sugiyama, M., Hasegawa, H., Ito, S., Sugiyama, K., Maeda, M., Aoki, K., Wakabayashi, T., Hamaguchi, M., Natsume, A., Senga, T."Paired related homeobox 1 is associated with the invasive properties of glioblastoma cells". Oncology Reports 33.3 (2015): 1123-1130.
Chicago
Sugiyama, M., Hasegawa, H., Ito, S., Sugiyama, K., Maeda, M., Aoki, K., Wakabayashi, T., Hamaguchi, M., Natsume, A., Senga, T."Paired related homeobox 1 is associated with the invasive properties of glioblastoma cells". Oncology Reports 33, no. 3 (2015): 1123-1130. https://doi.org/10.3892/or.2014.3681
Copy and paste a formatted citation
x
Spandidos Publications style
Sugiyama M, Hasegawa H, Ito S, Sugiyama K, Maeda M, Aoki K, Wakabayashi T, Hamaguchi M, Natsume A, Senga T, Senga T, et al: Paired related homeobox 1 is associated with the invasive properties of glioblastoma cells. Oncol Rep 33: 1123-1130, 2015.
APA
Sugiyama, M., Hasegawa, H., Ito, S., Sugiyama, K., Maeda, M., Aoki, K. ... Senga, T. (2015). Paired related homeobox 1 is associated with the invasive properties of glioblastoma cells. Oncology Reports, 33, 1123-1130. https://doi.org/10.3892/or.2014.3681
MLA
Sugiyama, M., Hasegawa, H., Ito, S., Sugiyama, K., Maeda, M., Aoki, K., Wakabayashi, T., Hamaguchi, M., Natsume, A., Senga, T."Paired related homeobox 1 is associated with the invasive properties of glioblastoma cells". Oncology Reports 33.3 (2015): 1123-1130.
Chicago
Sugiyama, M., Hasegawa, H., Ito, S., Sugiyama, K., Maeda, M., Aoki, K., Wakabayashi, T., Hamaguchi, M., Natsume, A., Senga, T."Paired related homeobox 1 is associated with the invasive properties of glioblastoma cells". Oncology Reports 33, no. 3 (2015): 1123-1130. https://doi.org/10.3892/or.2014.3681
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