Mitochondrial changes in endometrial carcinoma: Possible role in tumor diagnosis and prognosis (Review)

Cormio,Antonella; Cormio,Gennaro; Musicco,Clara; Sardanelli,Anna Maria; Gasparre,Giuseppe; Gadaleta,Maria Nicola

doi:10.3892/or.2014.3690

Mitochondrial changes in endometrial carcinoma: Possible role in tumor diagnosis and prognosis (Review)

Authors:
- Antonella Cormio
- Gennaro Cormio
- Clara Musicco
- Anna Maria Sardanelli
- Giuseppe Gasparre
- Maria Nicola Gadaleta
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Affiliations: Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy, Gynecologic Oncology Unit, IRCCS Istituto Oncologico ‘Giovanni Paolo II’, Bari, Italy, CNR-Institute of Biomembranes and Bioenergetics, Bari, Italy, Department of Basical Medical Sciences, Neurosciences and Sensory Organs, University of Bari, Bari, Italy, Department of Medical and Surgical Sciences, Unit of Medical Genetics, University of Bologna, Bologna, Italy
Published online on: December 22, 2014 https://doi.org/10.3892/or.2014.3690
Pages: 1011-1018

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Abstract

Endometrial carcinoma (EC) is a solid neoplasia for which a role for mitochondria in cancer progression is currently emerging and yet represents a diagnostic and prognostic challenge. EC is one of the most frequently occurring gynecological malignancies in the Western world whose incidence has increased significantly during the last decades. Here, we review the literature data on mitochondrial changes reported in EC, namely, mitochondrial DNA (mtDNA) mutations, increase in mitochondrial biogenesis and discuss whether they may be used as new cancer biomarkers for early detection and prognosis of this cancer.

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