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Review

Mitochondrial changes in endometrial carcinoma: Possible role in tumor diagnosis and prognosis (Review)

  • Authors:
    • Antonella Cormio
    • Gennaro Cormio
    • Clara Musicco
    • Anna Maria Sardanelli
    • Giuseppe Gasparre
    • Maria Nicola Gadaleta
  • View Affiliations / Copyright

    Affiliations: Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy, Gynecologic Oncology Unit, IRCCS Istituto Oncologico ‘Giovanni Paolo II’, Bari, Italy, CNR-Institute of Biomembranes and Bioenergetics, Bari, Italy, Department of Basical Medical Sciences, Neurosciences and Sensory Organs, University of Bari, Bari, Italy, Department of Medical and Surgical Sciences, Unit of Medical Genetics, University of Bologna, Bologna, Italy
  • Pages: 1011-1018
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    Published online on: December 22, 2014
       https://doi.org/10.3892/or.2014.3690
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Abstract

Endometrial carcinoma (EC) is a solid neoplasia for which a role for mitochondria in cancer progression is currently emerging and yet represents a diagnostic and prognostic challenge. EC is one of the most frequently occurring gynecological malignancies in the Western world whose incidence has increased significantly during the last decades. Here, we review the literature data on mitochondrial changes reported in EC, namely, mitochondrial DNA (mtDNA) mutations, increase in mitochondrial biogenesis and discuss whether they may be used as new cancer biomarkers for early detection and prognosis of this cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Cormio A, Cormio G, Musicco C, Sardanelli AM, Gasparre G and Gadaleta MN: Mitochondrial changes in endometrial carcinoma: Possible role in tumor diagnosis and prognosis (Review). Oncol Rep 33: 1011-1018, 2015.
APA
Cormio, A., Cormio, G., Musicco, C., Sardanelli, A.M., Gasparre, G., & Gadaleta, M.N. (2015). Mitochondrial changes in endometrial carcinoma: Possible role in tumor diagnosis and prognosis (Review). Oncology Reports, 33, 1011-1018. https://doi.org/10.3892/or.2014.3690
MLA
Cormio, A., Cormio, G., Musicco, C., Sardanelli, A. M., Gasparre, G., Gadaleta, M. N."Mitochondrial changes in endometrial carcinoma: Possible role in tumor diagnosis and prognosis (Review)". Oncology Reports 33.3 (2015): 1011-1018.
Chicago
Cormio, A., Cormio, G., Musicco, C., Sardanelli, A. M., Gasparre, G., Gadaleta, M. N."Mitochondrial changes in endometrial carcinoma: Possible role in tumor diagnosis and prognosis (Review)". Oncology Reports 33, no. 3 (2015): 1011-1018. https://doi.org/10.3892/or.2014.3690
Copy and paste a formatted citation
x
Spandidos Publications style
Cormio A, Cormio G, Musicco C, Sardanelli AM, Gasparre G and Gadaleta MN: Mitochondrial changes in endometrial carcinoma: Possible role in tumor diagnosis and prognosis (Review). Oncol Rep 33: 1011-1018, 2015.
APA
Cormio, A., Cormio, G., Musicco, C., Sardanelli, A.M., Gasparre, G., & Gadaleta, M.N. (2015). Mitochondrial changes in endometrial carcinoma: Possible role in tumor diagnosis and prognosis (Review). Oncology Reports, 33, 1011-1018. https://doi.org/10.3892/or.2014.3690
MLA
Cormio, A., Cormio, G., Musicco, C., Sardanelli, A. M., Gasparre, G., Gadaleta, M. N."Mitochondrial changes in endometrial carcinoma: Possible role in tumor diagnosis and prognosis (Review)". Oncology Reports 33.3 (2015): 1011-1018.
Chicago
Cormio, A., Cormio, G., Musicco, C., Sardanelli, A. M., Gasparre, G., Gadaleta, M. N."Mitochondrial changes in endometrial carcinoma: Possible role in tumor diagnosis and prognosis (Review)". Oncology Reports 33, no. 3 (2015): 1011-1018. https://doi.org/10.3892/or.2014.3690
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