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Article

MicroRNA‑135b regulates the stability of PTEN and promotes glycolysis by targeting USP13 in human colorectal cancers

  • Authors:
    • Shijun Xiang
    • Jiaqing Fang
    • Shuyun Wang
    • Biao Deng
    • Lin Zhu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai 200080, P.R. China, Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China
  • Pages: 1342-1348
    |
    Published online on: December 23, 2014
       https://doi.org/10.3892/or.2014.3694
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Abstract

Dysregulation of microRNAs has been reported to be involved in the progression of human colorectal cancers (CRCs). Loss of the adenomatous polyposis coli (APC) gene is a common initiating event in CRCs. PTEN inactivation by mutation or allelic loss also occurs in CRCs. miR‑135b was reported to be upregulated in CRCs and its overexpression was due to APC/β‑catenin and PTEN/PI3K pathway deregulation. APC was proven to be a target of miR‑135b and forms a feedback loop with miR‑135b. In the present study, we found that ubiquitin‑specific peptidase 13 (USP13) was a target of miR‑135b. miR‑135b downregulated the expression of USP13, and reduced the stability of PTEN. miR‑135b promoted cell proliferation and glycolysis that could be reversed by the overexpression of USP13 or PTEN. Moreover, knockdown of USP13 upregulated the levels of endogenous miR‑135b, but not those in CRC cells with PTEN mutation. The results showed positive feedback loops between miR‑135b and PTEN inactivation in CRCs.
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1 

Labianca R, Nordlinger B, Beretta GD, et al: Early colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 24:vi64–vi72. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Paquin MC, Leblanc C, Lemieux E, Bian B and Rivard N: Functional impact of colorectal cancer-associated mutations in the transcription factor E2F4. Int J Oncol. 43:2015–2022. 2013.PubMed/NCBI

3 

Garcia Sanchez J: Colonoscopic polypectomy and long-term prevention of colorectal cancer deaths. Rev Clin Esp. 212:4082012.(In Spanish).

4 

Nystrom M and Mutanen M: Diet and epigenetics in colon cancer. World J Gastroenterol. 15:257–263. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Kim YI: Nutritional epigenetics: impact of folate deficiency on DNA methylation and colon cancer susceptibility. J Nutr. 135:2703–2709. 2005.PubMed/NCBI

6 

Yamashita K, Dai T, Dai Y, Yamamoto F and Perucho M: Genetics supersedes epigenetics in colon cancer phenotype. Cancer Cell. 4:121–131. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Markman B, Javier Ramos F, Capdevila J and Tabernero J: EGFR and KRAS in colorectal cancer. Adv Clin Chem. 51:71–119. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Yu S, Xiao X, Lu J, Qian X, Liu B and Feng J: Colorectal cancer patients with low abundance of KRAS mutation may benefit from EGFR antibody therapy. PLoS One. 8:e680222013. View Article : Google Scholar : PubMed/NCBI

9 

Yokota T: Are KRAS/BRAF mutations potent prognostic and/or predictive biomarkers in colorectal cancers? Anticancer Agents Med Chem. 12:163–171. 2012. View Article : Google Scholar :

10 

Hamilton SR: BRAF mutation and microsatellite instability status in colonic and rectal carcinoma: context really does matter. J Natl Cancer Inst. 105:1075–1077. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Tonini G, Imperatori M, Vincenzi B, Frezza AM and Santini D: Rechallenge therapy and treatment holiday: different strategies in management of metastatic colorectal cancer. J Exp Clin Cancer Res. 32:922013. View Article : Google Scholar : PubMed/NCBI

12 

Fodde R: The APC gene in colorectal cancer. Eur J Cancer. 38:867–871. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Woodford-Richens KL, Rowan AJ, Gorman P, et al: SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway. Proc Natl Acad Sci USA. 98:9719–9723. 2001. View Article : Google Scholar : PubMed/NCBI

14 

de Weger VA, Turksma AW, Voorham QJ, et al: Clinical effects of adjuvant active specific immunotherapy differ between patients with microsatellitestable and microsatelliteinstable colon cancer. Clin Cancer Res. 18:882–889. 2012. View Article : Google Scholar

15 

Berg M, Danielsen SA, Ahlquist T, et al: DNA sequence profiles of the colorectal cancer critical gene set KRAS-BRAF- PIK3CA-PTEN-TP53 related to age at disease onset. PLoS One. 5:e139782010. View Article : Google Scholar

16 

Ilyas M, Tomlinson IP, Rowan A, Pignatelli M and Bodmer WF: Beta-catenin mutations in cell lines established from human colorectal cancers. Proc Natl Acad Sci USA. 94:10330–10334. 1997. View Article : Google Scholar : PubMed/NCBI

17 

Georgescu MM: PTEN tumor suppressor network in PI3K-Akt pathway control. Genes Cancer. 1:1170–1177. 2010. View Article : Google Scholar

18 

Song MS, Salmena L and Pandolfi PP: The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol. 13:283–296. 2012.PubMed/NCBI

19 

Nassif NT, Lobo GP, Wu X, et al: PTEN mutations are common in sporadic microsatellite stable colorectal cancer. Oncogene. 23:617–628. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Qin Q, Furong W and Baosheng L: Multiple functions of hypoxia-regulated miR-210 in cancer. J Exp Clin Cancer Res. 33:502014. View Article : Google Scholar : PubMed/NCBI

21 

Wang Y and Taniguchi T: MicroRNAs and DNA damage response: implications for cancer therapy. Cell Cycle. 12:32–42. 2013. View Article : Google Scholar :

22 

Krishnan K, Steptoe AL, Martin HC, et al: MicroRNA-182-5p targets a network of genes involved in DNA repair. RNA. 19:230–242. 2013. View Article : Google Scholar :

23 

He YQ, Sheng JQ, Ling XL, et al: Estradiol regulates miR-135b and mismatch repair gene expressions via estrogen receptor-beta in colorectal cells. Exp Mol Med. 44:723–732. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Ma L, Teruya-Feldstein J and Weinberg RA: Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature. 449:682–688. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Pencheva N and Tavazoie SF: Control of metastatic progression by microRNA regulatory networks. Nat Cell Biol. 15:546–554. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Rottiers V and Näär AM: MicroRNAs in metabolism and metabolic disorders. Nat Rev Mol Cell Biol. 13:239–250. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Dumortier O, Hinault C and Van Obberghen E: MicroRNAs and metabolism crosstalk in energy homeostasis. Cell Metab. 18:312–324. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Zhai H and Ju J: Implications of microRNAs in colorectal cancer development, diagnosis, prognosis, and therapeutics. Front Genet. 2:782011. View Article : Google Scholar :

29 

Dong Y, Wu WK, Wu CW, Sung JJ, Yu J and Ng SS: MicroRNA dysregulation in colorectal cancer: a clinical perspective. Br J Cancer. 104:893–898. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Schetter AJ, Okayama H and Harris CC: The role of microRNAs in colorectal cancer. Cancer J. 18:244–252. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Brunet Vega A, Pericay C, Moya I, et al: microRNA expression profile in stage III colorectal cancer: Circulating miR-18a and miR-29a as promising biomarkers. Oncol Rep. 30:320–326. 2013.PubMed/NCBI

32 

Khatri R and Subramanian S: MicroRNA-135b and its circuitry networks as potential therapeutic targets in colon cancer. Front Oncol. 3:2682013. View Article : Google Scholar : PubMed/NCBI

33 

Wu CW, Ng SC, Dong Y, et al: Identification of microRNA-135b in stool as a potential noninvasive biomarker for colorectal cancer and adenoma. Clin Cancer Res. 20:2994–3002. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Wu W, Wang Z, Yang P, et al: MicroRNA-135b regulates metastasis suppressor 1 expression and promotes migration and invasion in colorectal cancer. Mol Cell Biochem. 388:249–259. 2014. View Article : Google Scholar

35 

Munding JB, Adai AT, Maghnouj A, et al: Global microRNA expression profiling of microdissected tissues identifies miR-135b as a novel biomarker for pancreatic ductal adenocarcinoma. Int J Cancer. 131:E86–E95. 2012. View Article : Google Scholar

36 

Valeri N, Braconi C, Gasparini P, et al: MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell. 25:469–483. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Lee JT, Shan J, Zhong J, et al: RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation. Cell Res. 23:552–564. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Wang X, Trotman LC, Koppie T, et al: NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell. 128:129–139. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Zhang J, Zhang P, Wei Y, et al: Deubiquitination and stabilization of PTEN by USP13. Nat Cell Biol. 15:1486–1494. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Donohoe DR, Collins LB, Wali A, Bigler R, Sun W and Bultman SJ: The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation. Mol Cell. 48:612–626. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Najafov A and Alessi DR: Uncoupling the Warburg effect from cancer. Proc Natl Acad Sci USA. 107:19135–19136. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Faltejskova P, Bocanek O, Sachlova M, et al: Circulating miR-17-3p, miR-29a, miR-92a and miR-135b in serum: evidence against their usage as biomarkers in colorectal cancer. Cancer Biomark. 12:199–204. 2012.PubMed/NCBI

43 

Xu XM, Qian JC, Deng ZL, et al: Expression of miR-21, miR-31, miR-96 and miR-135b is correlated with the clinical parameters of colorectal cancer. Oncol Lett. 4:339–345. 2012.PubMed/NCBI

44 

Zhao Y, Butler EB and Tan M: Targeting cellular metabolism to improve cancer therapeutics. Cell Death Dis. 4:e5322013. View Article : Google Scholar : PubMed/NCBI

45 

Ahmed D, Eide PW, Eilertsen IA, et al: Epigenetic and genetic features of 24 colon cancer cell lines. Oncogenesis. 2:e712013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xiang S, Fang J, Wang S, Deng B and Zhu L: MicroRNA‑135b regulates the stability of PTEN and promotes glycolysis by targeting USP13 in human colorectal cancers. Oncol Rep 33: 1342-1348, 2015.
APA
Xiang, S., Fang, J., Wang, S., Deng, B., & Zhu, L. (2015). MicroRNA‑135b regulates the stability of PTEN and promotes glycolysis by targeting USP13 in human colorectal cancers. Oncology Reports, 33, 1342-1348. https://doi.org/10.3892/or.2014.3694
MLA
Xiang, S., Fang, J., Wang, S., Deng, B., Zhu, L."MicroRNA‑135b regulates the stability of PTEN and promotes glycolysis by targeting USP13 in human colorectal cancers". Oncology Reports 33.3 (2015): 1342-1348.
Chicago
Xiang, S., Fang, J., Wang, S., Deng, B., Zhu, L."MicroRNA‑135b regulates the stability of PTEN and promotes glycolysis by targeting USP13 in human colorectal cancers". Oncology Reports 33, no. 3 (2015): 1342-1348. https://doi.org/10.3892/or.2014.3694
Copy and paste a formatted citation
x
Spandidos Publications style
Xiang S, Fang J, Wang S, Deng B and Zhu L: MicroRNA‑135b regulates the stability of PTEN and promotes glycolysis by targeting USP13 in human colorectal cancers. Oncol Rep 33: 1342-1348, 2015.
APA
Xiang, S., Fang, J., Wang, S., Deng, B., & Zhu, L. (2015). MicroRNA‑135b regulates the stability of PTEN and promotes glycolysis by targeting USP13 in human colorectal cancers. Oncology Reports, 33, 1342-1348. https://doi.org/10.3892/or.2014.3694
MLA
Xiang, S., Fang, J., Wang, S., Deng, B., Zhu, L."MicroRNA‑135b regulates the stability of PTEN and promotes glycolysis by targeting USP13 in human colorectal cancers". Oncology Reports 33.3 (2015): 1342-1348.
Chicago
Xiang, S., Fang, J., Wang, S., Deng, B., Zhu, L."MicroRNA‑135b regulates the stability of PTEN and promotes glycolysis by targeting USP13 in human colorectal cancers". Oncology Reports 33, no. 3 (2015): 1342-1348. https://doi.org/10.3892/or.2014.3694
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